当前位置： SCI文献检索 > JOURNAL OF AFFECTIVE DISORDERS期刊下所有文献 > The GSK3B gene confers risk for both major depressive disorder and schizophrenia in the Han Chinese population.

The GSK3B gene confers risk for both major depressive disorder and schizophrenia in the Han Chinese population.

Abstract：

BACKGROUND:Glycogen synthease kinase-3B is a key gene encoding a protein kinase which is abundant in brain, and is involved in signal transduction cascades of neuronal cell development and energy metabolism. Previous researches proposed GSK3B as a potential region for schizophrenia. METHOD:To validate the susceptibility of GSK3B to major depressive disorder, and to investigate the overlapping risk conferred by GSK3B for mental disorders, we performed a large-scale case-control study, analyzed 6 tag single nucleotide polymorphisms using TaqMan® technology in 1,045 major depressive disorder patients, 1,235 schizophrenia patients and 1,235 normal controls of Han Chinese origin. RESULTS:We found rs334535 (Pallele=2.79E-03, Pgenotype=5.00E-03, OR=1.429) and rs2199503 (Pallele=0.020, Pgenotype= 0.040, OR=1.157) showed association with major depressive disorder before Bonferroni correction. rs6771023 (adjusted Pallele=1.64E-03, adjusted Pgenotype=6.00E-03, OR=0.701) and rs2199503 (adjusted Pallele=0.001, adjusted Pgenotype=0.002, OR=1.251) showed significant association with schizophrenia after Bonferroni correction. rs2199503 (adjusted Pallele=1.70E-03, adjusted Pgenotype=0.006, OR=1.208) remained to be significant in the combined cases of major depressive disorder and schizophrenia after Bonferroni correction. LIMITATIONS:Further validations of our findings in samples with larger scale are suggested, and functional genomic study is needed to elucidate the role of GSK3B in signal pathway and psychiatric disorders. CONCLUSIONS:Our results provide evidence that the GSK3B gene could be a promising region which contains genetic risk for both major depressive disorder and schizophrenia in the Han Chinese population. The study on variants conferring overlapping risk for multiple psychiatric disorders could be tangible pathogenesis support and clinical or diagnostic references.

journal_name

J Affect Disord

journal_title

Journal of affective disorders

authors

Chen J,Wang M,Waheed Khan RA,He K,Wang Q,Li Z,Shen J,Song Z,Li W,Wen Z,Jiang Y,Xu Y,Shi Y,Ji W

doi

10.1016/j.jad.2015.06.040

subject

Has Abstract

pub_date

2015-10-01 00:00:00

pages

149-55

eissn

0165-0327

issn

1573-2517

pii

S0165-0327(15)00406-1

journal_volume

185

pub_type

杂志文章

相关文献

JOURNAL OF AFFECTIVE DISORDERS文献大全
  • Effect of some climatic factors on violent and non-violent suicides in Belgium.

    abstract：:We explored the differential effect of some climatic factors such as temperature, atmospheric pressure, sunlight duration and humidity grade on the temporal distribution of violent and non-violent suicides, accidental and undetermined causes of death as well as homicides in Belgium, between 1969 and 1984. Our study in...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/0165-0327(92)90001-m

    authors： Linkowski P,Martin F,De Maertelaer V

    更新日期：1992-07-01 00:00:00

  • Systematic review and meta-analysis of the role of personality disorder in randomised controlled trials of pharmacological interventions for adults with mood disorders.

    abstract：BACKGROUND:Personality disorder (PD) may affect the efficacy of pharmacological interventions for mood disorders, but the extent to which this occurs is uncertain. We aimed to examine the available published evidence concerning the role of PD in pharmacological treatment outcomes of randomised controlled trials (RCTs) ...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章,评审

    doi：10.1016/j.jad.2020.10.031

    authors： Kavanagh BE,Ashton MM,Cowdery SP,Dean OM,Turner A,Berk M,Gwini SM,Brennan-Olsen SL,Koivumaa-Honkanen H,Chanen AM,Williams LJ

    更新日期：2021-01-15 00:00:00

  • Bupropion and paroxetine differentially influence cardiovascular and neuroendocrine responses to stress in depressed patients.

    abstract：BACKGROUND:There exists a need to identify safe and effective treatments for depression in patients with coronary heart disease (CHD). METHODS:Using a cross-sectional design, 17 depressed patients being treated with bupropion (200-450 mg/day) were compared with 17 depressed patients being treated with paroxetine (10-5...

    journal_title：Journal of affective disorders

    pub_type： 临床试验,杂志文章

    doi：10.1016/S0165-0327(02)00352-X

    authors： Straneva-Meuse PA,Light KC,Allen MT,Golding M,Girdler SS

    更新日期：2004-04-01 00:00:00

  • Serum BDNF concentration after delivery is associated with development of postpartum depression: A 3-month follow up study.

    abstract：BACKGROUND:Our aim was to determine whether there is a relationship between serum brain-derived neurotrophic factor (BDNF) and postpartum depression (PPD) in a cohort Chinese population. METHODS:From May 1, 2014, to September 30, 2014, all eligible women not on medication for depression giving birth at the Fourth Affi...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2016.04.002

    authors： Gao X,Wang J,Yao H,Cai Y,Cheng R

    更新日期：2016-08-01 00:00:00

  • Recovery in bipolar depression: Post-hoc analysis of a placebo-controlled lurasidone trial followed by a long-term continuation study.

    abstract：BACKGROUND:In this post-hoc analysis, rates of remission and recovery were evaluated in patients with bipolar depression treated with lurasidone. METHODS:Outpatients meeting DSM-IV-TR criteria for bipolar I depression, were randomized to 6 weeks of once-daily, double-blind treatment with lurasidone 20-60mg, lurasidone...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jad.2015.07.033

    authors： Loebel A,Siu C,Rajagopalan K,Pikalov A,Cucchiaro J,Ketter TA

    更新日期：2015-11-01 00:00:00

  • Prevalence of suicide ideation, planning and attempts among Supplemental Nutrition Assistance Program participants in the United States.

    abstract：BACKGROUND:Suicide represents a substantial public health problem in the U.S. Programs like the Supplemental Nutrition Assistance Program (SNAP)-which provides services for U.S. adults who are food insecure-could be an appropriate venue for suicide prevention strategies targeting high-risk individuals. METHODS:This cr...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2020.07.129

    authors： Bergmans RS,Jannausch M,Ilgen MA

    更新日期：2020-12-01 00:00:00

  • Diminished perception of light as a symptom of depression: further studies.

    abstract：BACKGROUND:In a previous preliminary report, the perception of a decrease in ambient light intensity appeared to be correlated with depression. We prospectively studied this potential link in a controlled study. METHODS:The question, "I've noticed that the lights in my surroundings seem dimmer than usual", was added t...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jad.2007.10.021

    authors： Friberg TR,Bremer RW,Dickinsen M

    更新日期：2008-06-01 00:00:00

  • Serotonin transporter polymorphisms, microstructural white matter abnormalities and remission of geriatric depression.

    abstract：OBJECTIVE:This study compared microstructural abnormalities in depressed elders and controls and studied the association of the serotonin transporter gene status to white matter abnormalities and to remission of depression. METHODS:The subjects were Caucasians with non-psychotic major depression and normal elders. Dep...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2009.03.004

    authors： Alexopoulos GS,Murphy CF,Gunning-Dixon FM,Glatt CE,Latoussakis V,Kelly RE Jr,Kanellopoulos D,Klimstra S,Lim KO,Young RC,Hoptman MJ

    更新日期：2009-12-01 00:00:00

  • MDQ positive people's searching for effective and ineffective treatments for bipolar disorders: a screening study in France.

    abstract：INTRODUCTION:The objective was to estimate the rate of subjects who tested positive at a screening for bipolar disorders among the people insured by a French Health Company, and subsequently to measure treatment patterns. METHODS:Cross-sectional postal survey on the "Mutuelle Générale de l'Education Nationale" (MGEN) ...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2013.01.007

    authors： Carta MG,Zairo F,Saphino D,Sevilla-Dedieu C,Moro MF,Massidda D,Kovess V

    更新日期：2013-07-01 00:00:00

  • Swimming exercise reverses CUMS-induced changes in depression-like behaviors and hippocampal plasticity-related proteins.

    abstract：BACKGROUND:Stress-induced failed resilience of brain plasticity can contribute to the onset and recurrence of depression. Chronic stress has been reported to open windows of epigenetic plasticity in hippocampus. However, how hippocampal plasticity underlies depression-like behaviors and how it adapts in response to str...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2017.10.019

    authors： Liu W,Xue X,Xia J,Liu J,Qi Z

    更新日期：2018-02-01 00:00:00

  • The factor structure of depressive symptoms in patients with obesity enrolled in the RAINBOW clinical trial.

    abstract：BACKGROUND:Examining variability in the presenting symptoms of depression may be particularly important in characterizing depression in patients with comorbid conditions such as obesity. Identifying the underlying constructs of depression in such patients may produce phenotypic information to aid diagnosis and treatmen...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2020.11.105

    authors： Majd M,Smyth JM,Lv N,Xiao L,Snowden MB,Venditti EM,Williams LM,Ajilore OA,Suppes T,Ma J

    更新日期：2021-02-15 00:00:00

  • The long-term outcome of a depressive population in a Hungarian material.

    abstract：:The authors made a follow-up study among 118 depressive patients. The follow-up period was 11 years (mean 7.8 years). They have used the operational criteria elaborated by Lee and Murray. The suicide rate was 2.54%, calculated for annual average per 100000 inhabitants is 231.5. This figure is close to ten times higher...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/s0165-0327(99)00168-8

    authors： Zonda T,Gróza J

    更新日期：2000-11-01 00:00:00

  • Effects of electroconvulsive therapy on neural complexity in patients with depression: report of three cases.

    abstract：BACKGROUND:The exact neurophysiological mechanism of electroconvulsive therapy (ECT) for treating patients with depression remains elusive. Results of previous neurophysiological studies support the hypothesis that aberrant functional connectivity underlies the pathophysiology of depression, which engenders abnormal el...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2013.04.029

    authors： Okazaki R,Takahashi T,Ueno K,Takahashi K,Higashima M,Wada Y

    更新日期：2013-09-05 00:00:00

  • Affective and cognitive reactivity to mood induction in chronic depression.

    abstract：BACKGROUND:Chronic depression (CD) is strongly associated with childhood maltreatment, which has been proposed to lead to inefficient coping styles that are characterized by abnormal affective responsiveness and dysfunctional cognitive attitudes. However, while this notion forms an important basis for psychotherapeutic...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2017.12.090

    authors： Guhn A,Sterzer P,Haack FH,Köhler S

    更新日期：2018-03-15 00:00:00

  • Darwinian depression.

    abstract：BACKGROUND:The standard evolutionary explanation for depression is that being in an emotionally depressed state is adaptive. METHOD:The article first undertakes a critical review of the extant literature. It then provides an alternative evolutionary explanation for event-based depression and elation. It argues that be...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章,评审

    doi：10.1016/j.jad.2014.06.052

    authors： Wittman D

    更新日期：2014-10-01 00:00:00

  • Parental overprotection increases sociotropy with gender specificity in parents and recipients.

    abstract：BACKGROUND:There have been few studies which examined the developmental origins of cognitive vulnerability of depression. The purpose of the present study was to examine the effects of parental rearing on sociotropy and autonomy, the personality vulnerability factors in the cognitive theory of depression. METHODS:The ...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2011.09.033

    authors： Otani K,Suzuki A,Kamata M,Matsumoto Y,Shibuya N,Sadahiro R,Enokido M

    更新日期：2012-02-01 00:00:00

  • Body dysmorphic disorder in outpatients with major depression.

    abstract：BACKGROUND:Body dysmorphic disorder (BDD) is a distressing and impairing preoccupation with an imagined or slight defect in appearance, with depression as its most frequent comorbid condition. The purpose of this study was to evaluate the rate of BDD in a cohort of consecutive outpatients with typical and atypical majo...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/s0165-0327(01)00304-4

    authors： Nierenberg AA,Phillips KA,Petersen TJ,Kelly KE,Alpert JE,Worthington JJ,Tedlow JR,Rosenbaum JF,Fava M

    更新日期：2002-05-01 00:00:00

  • Prediction of antidepressant response in both 2.25xthreshold RUL and fixed high dose RUL ECT.

    abstract：UNLABELLED:Some forms of electroconvulsive therapy (ECT) can result in generalized seizures that lack efficacy, therefore physiological markers of treatment adequacy would be helpful. EEG measures of seizure quality, such as EEG regularity and post-ictal suppression, have largely supplanted seizure duration as a marker...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jad.2008.03.030

    authors： Kimball JN,Rosenquist PB,Dunn A,McCall WV

    更新日期：2009-01-01 00:00:00

  • Chronic medical conditions and metabolic syndrome as risk factors for incidence of major depressive disorder: A longitudinal study based on 4.7 million adults in South Korea.

    abstract：BACKGROUND:The assessment of comorbid physical illness and metabolic or cardiovascular risk factors as potential risk factors for onset of major depressive disorder (MDD) is crucial. We aimed to investigate potential risk factors for the development of MDD among individuals with chronic medical conditions and metabolic...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2019.07.003

    authors： Han KM,Kim MS,Kim A,Paik JW,Lee J,Ham BJ

    更新日期：2019-10-01 00:00:00

  • What are the effects of preventative interventions on major depressive disorder (MDD) in young adults? A systematic review and meta-analysis of randomized controlled trials.

    abstract：BACKGROUND:Depression is a prevalent disorder with a peak rate of onset in young adulthood from 18 to 25 years. To date, no review has systematically assessed the effectiveness of programs that aim to reduce depressive symptoms or diagnosis of depression in young adults. METHOD:A systematic search was performed in Coc...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.jad.2018.05.010

    authors： Breedvelt JJF,Kandola A,Kousoulis AA,Brouwer ME,Karyotaki E,Bockting CLH,Cuijpers P

    更新日期：2018-10-15 00:00:00

  • BP neural network prediction model for suicide attempt among Chinese rural residents.

    abstract：OBJECTIVE:This study aimed to establish and assess the Back Propagation Neural Network (BPNN) prediction model for suicide attempt, so as to improve the individual prediction accuracy. METHOD:Data was collected from a wide range case-control suicide attempt survey. 659 serious suicide attempters (case group) were rand...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2018.12.111

    authors： Lyu J,Zhang J

    更新日期：2019-03-01 00:00:00

  • Examining sex differences in the impact of anticipated and actual life events.

    abstract：:To examine for sex differences in anticipated and actual impact of pleasant and unpleasant life events in a non-clinical group, a cohort of 164 subjects was initially assessed in 1978 in their last year of teacher training. They were asked to participate in the life events study in 1979, and 97 subjects complied, prov...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/s0165-0327(97)00138-9

    authors： Wilhelm K,Parker G,Dewhurst J

    更新日期：1998-02-01 00:00:00

  • Repeated administration of antidepressant drugs reduces regional somatostatin concentrations in rat brain.

    abstract：:A possible role for somatostatin in affective disorders is suggested by its low concentration in cerebrospinal fluid of patients with depression. Therefore, we studied the regional effects of antidepressant drugs and antimanic agents on somatostatin concentrations in rat brain. Repeated, but not acute, administration ...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/0165-0327(92)90078-k

    authors： Kakigi T,Maeda K,Kaneda H,Chihara K

    更新日期：1992-08-01 00:00:00

  • In-patient care costs of patients with bipolar I disorder: a comparison between two European centers.

    abstract：BACKGROUND:Bipolar disorder (BPD) is a disabling disease with high morbidity rates. An international (Spain, France) comparative study about hospitalizations and in-patient care costs associated with BPD I was performed. Centers were included if they had access to a database of computerized patient charts exhaustively ...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2009.05.010

    authors： Gonzalez-Pinto AM,Dardennes R,de Zélicourt M,López P,Oliveros RG,Vieta E,Barbeito S,Echevarria E,Fagnani F

    更新日期：2010-02-01 00:00:00

  • Shank3 as a potential biomarker of antidepressant response to ketamine and its neural correlates in bipolar depression.

    abstract：BACKGROUND:Shank3, a post-synaptic density protein involved in N-methyl-d-aspartate (NMDA) receptor tethering and dendritic spine rearrangement, is implicated in the pathophysiology of bipolar disorder. We hypothesized that elevated baseline plasma Shank3 levels might predict antidepressant response to the NMDA recepto...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jad.2014.09.015

    authors： Ortiz R,Niciu MJ,Lukkahati N,Saligan LN,Nugent AC,Luckenbaugh DA,Machado-Vieira R,Zarate CA Jr

    更新日期：2015-02-01 00:00:00

  • Olanzapine versus haloperidol in schizoaffective disorder, bipolar type.

    abstract：BACKGROUND:The present analysis was performed on data from a subsample of patients with schizoaffective disorder, bipolar type, who participated in a multicenter, double-blind study comparing olanzapine to haloperidol. METHODS:Patients with schizoaffective disorder bipolar type, characterized as currently manic, mixed...

    journal_title：Journal of affective disorders

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/s0165-0327(00)00303-7

    authors： Tohen M,Zhang F,Keck PE,Feldman PD,Risser RC,Tran PV,Breier A

    更新日期：2001-12-01 00:00:00

  • Do patients with bipolar disorder drink alcohol for different reasons when depressed, manic or euthymic?

    abstract：OBJECTIVE:Many studies report high prevalence rates for co-morbid alcohol problems in bipolar disorder (BP). Some hypothesize that individuals use alcohol to self-medicate, but few studies examine the range of possible reasons and none explicitly explores the role of mood state. We examined drinking motives in BP depre...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2011.09.005

    authors： Meyer TD,McDonald JL,Douglas JL,Scott J

    更新日期：2012-02-01 00:00:00

  • Ocular motor differences between melancholic and non-melancholic depression.

    abstract：BACKGROUND:Major depressive disorder may be a heterogeneous disorder, yet melancholic depression is the most consistently described subtype, regarded as qualitatively different to non-melancholic depression in terms of cognitive and motor impairments. Eye movement studies in depression are infrequent and findings are i...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2006.03.018

    authors： Winograd-Gurvich C,Georgiou-Karistianis N,Fitzgerald PB,Millist L,White OB

    更新日期：2006-07-01 00:00:00

  • Medication treatment perceptions, concerns and expectations among depressed individuals with Type I Bipolar Disorder.

    abstract：BACKGROUND:Subjective experience of illness affects outcomes among populations with bipolar disorder (BD). This cross-sectional study combined qualitative and quantitative approaches to evaluate perceived treatment effects, concerns and expectations among 90 individuals with BD. METHODS:Adults with Type I BD, mean age...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jad.2008.10.002

    authors： Sajatovic M,Jenkins JH,Cassidy KA,Muzina DJ

    更新日期：2009-06-01 00:00:00

  • Cerebral ventricular size in panic disorder.

    abstract：:Computed axial brain tomography was studied in 25 patients with panic disorder. Patients had normal ventricular-brain ratio (VBR) compared to published norms. There was a significant association between VBR and duration of benzodiazepine use. ...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/0165-0327(87)90011-5

    authors： Uhde TW,Kellner CH

    更新日期：1987-03-01 00:00:00