Olanzapine versus haloperidol in schizoaffective disorder, bipolar type.

Abstract:

BACKGROUND:The present analysis was performed on data from a subsample of patients with schizoaffective disorder, bipolar type, who participated in a multicenter, double-blind study comparing olanzapine to haloperidol. METHODS:Patients with schizoaffective disorder bipolar type, characterized as currently manic, mixed, depressed, or euthymic, were assessed weekly for 6 weeks during treatment with either olanzapine or haloperidol. Manic symptoms were measured using the sum of six items of the BPRS, and depressive symptoms were assessed using the Montgomery-Asberg Depression Rating Scale. In addition, cognitive functioning was measured using the sum of seven items from the PANSS. Repeated measures analyses were performed using random coefficients regression of the serial measurement of manic, cognitive, and depressive symptoms. RESULTS:A significant treatment difference was detected overall, indicating that olanzapine was significantly more effective than haloperidol in reducing symptoms of depression and improving patients' cognitive symptoms. The superiority of olanzapine over haloperidol in the reduction of manic symptoms did not reach statistical significance (P=.052). The greatest improvement in both manic and cognitive symptoms was seen in the olanzapine-treated 'currently manic' subgroup, and least improvement in the haloperidol-treated 'euthymic' subgroup. Depressive symptoms were most improved in the olanzapine-treated 'depressed' subgroup, and least improved in the corresponding haloperidol subgroup. CONCLUSIONS:Overall, olanzapine was superior to haloperidol with respect to thymoleptic effects in patients with schizoaffective disorder, bipolar type.

journal_name

J Affect Disord

authors

Tohen M,Zhang F,Keck PE,Feldman PD,Risser RC,Tran PV,Breier A

doi

10.1016/s0165-0327(00)00303-7

subject

Has Abstract

pub_date

2001-12-01 00:00:00

pages

133-40

issue

1-3

eissn

0165-0327

issn

1573-2517

pii

S0165032700003037

journal_volume

67

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
  • Imipramine and weight gain during the long-term treatment of recurrent depression.

    abstract::The recently completed long-term maintenance trial of full-dose imipramine for recurrent unipolar disorder provided an opportunity to examine the extent to which such doses (200-300 mg daily) are associated with persistent and adverse side effects, particularly weight change. In 115 patients we monitored weight change...

    journal_title:Journal of affective disorders

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0165-0327(92)90036-6

    authors: Frank E,Kupfer DJ,Buhari A,McEachran AB,Grochocinski VJ

    更新日期:1992-09-01 00:00:00

  • Piloting the 'Youth Early-intervention Study' ('YES'): Preliminary functional outcomes of a randomized controlled trial targeting social participation and physical well-being in young people with emerging mental disorders.

    abstract:INTRODUCTION:Young people with mental disorders present with diverse social, vocational, physical, and developmental needs. However, multifaceted interventions are rare. We examine the effectiveness of a clinical trial targeting social participation and physical well-being in young people accessing clinical services. ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2020.10.070

    authors: Gehue LJ,Crouse JJ,Battisti RA,Yim M,Carpenter JS,Scott EM,Hickie IB

    更新日期:2021-02-01 00:00:00

  • Prevalence of suicide ideation, planning and attempts among Supplemental Nutrition Assistance Program participants in the United States.

    abstract:BACKGROUND:Suicide represents a substantial public health problem in the U.S. Programs like the Supplemental Nutrition Assistance Program (SNAP)-which provides services for U.S. adults who are food insecure-could be an appropriate venue for suicide prevention strategies targeting high-risk individuals. METHODS:This cr...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2020.07.129

    authors: Bergmans RS,Jannausch M,Ilgen MA

    更新日期:2020-12-01 00:00:00

  • GWAS and systems biology analysis of depressive symptoms among smokers from the COPDGene cohort.

    abstract:BACKGROUND:Large sample GWAS is needed to identify genetic factors associated with depression. This study used genome-wide genotypic and phenotypic data from the COPDGene study to identify genetic risk factors for depression. METHODS:Data were from 9716 COPDGene subjects with ≥10 pack-year history. Depression was defi...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2018.09.003

    authors: Heinzman JT,Hoth KF,Cho MH,Sakornsakolpat P,Regan EA,Make BJ,Kinney GL,Wamboldt FS,Holm KE,Bormann N,Robles J,Kim V,Iyer AS,Silverman EK,Crapo JD,Han S,Potash JB,Shinozaki G,COPDGene Investigators.

    更新日期:2019-01-15 00:00:00

  • A morphometric study of glia and neurons in the anterior cingulate cortex in mood disorder.

    abstract:BACKGROUND:The anterior cingulate cortex (ACC) is a key region for the pathophysiology and treatment of depression. However, it remains unclear whether and how the morphology of the ACC is altered in subjects with mood disorders. METHOD:A post mortem morphometric study of the supragenual ACC (Brodmann area 24b) in sev...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2011.03.042

    authors: Gittins RA,Harrison PJ

    更新日期:2011-09-01 00:00:00

  • A three-year longitudinal study of affective temperaments and risk for psychopathology.

    abstract:BACKGROUND:Affective temperaments are presumed to underlie bipolar psychopathology. The TEMPS-A has been widely used to assess affective temperaments in clinical and non-clinical samples. Cross-sectional research supports the association of affective temperaments and mood psychopathology; however, longitudinal research...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2014.04.006

    authors: DeGeorge DP,Walsh MA,Barrantes-Vidal N,Kwapil TR

    更新日期:2014-08-01 00:00:00

  • Determinants of occupational and residential functioning in bipolar disorder.

    abstract:BACKGROUND:Bipolar disorder is associated with reduced rates of employment and residential independence. The influence of cognitive impairment and affective symptoms on these functional attainments has received little previous attention and is the focus of this study. METHOD:A total of 229 adult outpatients with bipol...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2011.09.035

    authors: Depp CA,Mausbach BT,Bowie C,Wolyniec P,Thornquist MH,Luke JR,McGrath JA,Pulver AE,Harvey PD,Patterson TL

    更新日期:2012-02-01 00:00:00

  • Increased plasma peroxides and serum oxidized low density lipoprotein antibodies in major depression: markers that further explain the higher incidence of neurodegeneration and coronary artery disease.

    abstract:BACKGROUND:Major depression is characterized by a decreased antioxidant status, an induction of the inflammatory and oxidative and nitrosative (IO&NS) pathways and inflammatory-neurodegenerative (I&ND) pathways. This study examines two markers of oxidative stress in depression, i.e. plasma peroxides and serum oxidized ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2009.12.014

    authors: Maes M,Mihaylova I,Kubera M,Uytterhoeven M,Vrydags N,Bosmans E

    更新日期:2010-09-01 00:00:00

  • Momentary assessment of PTSD symptoms and sexual risk behavior in male OEF/OIF/OND Veterans.

    abstract:BACKGROUND:Post-traumatic stress disorder (PTSD) in Veterans is associated with increased sexual risk behaviors, but the nature of this association is not well understood. Typical PTSD measurement deriving a summary estimate of symptom severity over a period of time precludes inferences about symptom variability, and w...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2015.10.039

    authors: Black AC,Cooney NL,Justice AC,Fiellin LE,Pietrzak RH,Lazar CM,Rosen MI

    更新日期:2016-01-15 00:00:00

  • Does melancholia predict response in major depression?

    abstract::We examined the value of the melancholic distinction for predicting response to 1 week of hospitalization without antidepressant drugs and to a 4-week fixed plasma level desipramine (DMI) trial in patients with unipolar non-psychotic major depression. Both DSM-III and III-R criteria were tested. Response to hospitaliz...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/0165-0327(90)90032-4

    authors: Nelson JC,Mazure CM,Jatlow PI

    更新日期:1990-03-01 00:00:00

  • Mindfulness-based interventions in the early phase of affective and non-affective psychoses: Special Section on "Translational and Neuroscience Studies in Affective Disorders" Section Editor, Maria Nobile MD, PhD.

    abstract:BACKGROUND:In the last 10 years, psychological approaches based on mindfulness techniques have been proposed for the management of psychotic experiences. METHOD:In this brief review we summarized, to our knowledge for the first time, published studies on mindfulness-based interventions (MBIs) applied to the early phas...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2019.10.011

    authors: Perlini C,Bellani M,Rossetti MG,Rossin G,Zovetti N,Rossi A,Bressi C,Piccolo LD,Brambilla P

    更新日期:2020-02-15 00:00:00

  • Is subclinical anxiety an endophenotype for bipolar I patients? A study from a Costa Rican sample.

    abstract:BACKGROUND:Although genetic influences on bipolar I disorder are well established, localization of genes that predispose to the illness has been difficult. Some genes predisposing to bipolar I disorder may be transmitted without expression of the categorical clinical phenotype. One strategy to overcome this obstacle is...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2009.07.017

    authors: Contreras J,Hare E,Pacheco A,Escamilla M,Raventos H

    更新日期:2010-05-01 00:00:00

  • Longitudinal association of PTSD symptoms and self-reported physical functioning among Veterans.

    abstract:BACKGROUND:Few longitudinal studies have investigated the potentially dynamic relationship between Posttraumatic Stress Disorder (PTSD) and physical functioning, and the number of follow-up timepoints have been limited. We evaluated whether PTSD symptoms predicted future physical functioning and vice versa using five a...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2019.02.048

    authors: Ahmadian AJ,Neylan TC,Metzler T,Cohen BE

    更新日期:2019-05-01 00:00:00

  • Toward an integrative model of the spectrum of mood, behavioral and personality disorders based on fear and anger traits: I. Clinical implications.

    abstract::Current formal psychiatric approaches to nosology are plagued by an unwieldy degree of heterogeneity with insufficient appreciation of the commonalities of emotional, personality, behavioral, and addictive disorders. We address this challenge by building a spectrum model that integrates the advantages of Cloninger's a...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,评审

    doi:10.1016/j.jad.2006.02.025

    authors: Lara DR,Pinto O,Akiskal K,Akiskal HS

    更新日期:2006-08-01 00:00:00

  • A trajectory-based approach to understand the factors associated with persistent depressive symptoms in primary care.

    abstract:BACKGROUND:Depression screening in primary care yields high numbers. Knowledge of how depressive symptoms change over time is limited, making decisions about type, intensity, frequency and length of treatment and follow-up difficult. This study is aimed to identify depressive symptom trajectories and associated socio-d...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2012.12.021

    authors: Gunn J,Elliott P,Densley K,Middleton A,Ambresin G,Dowrick C,Herrman H,Hegarty K,Gilchrist G,Griffiths F

    更新日期:2013-06-01 00:00:00

  • Major depression in cardiology chest pain patients without coronary artery disease and with panic disorder.

    abstract::104 patients in a cardiology clinic with atypical or non-anginal chest pain were studied through a structured clinical interview. 43 without coronary artery disease fit diagnostic criteria for panic disorder. 19 (44%) of this group reported a lifetime prevalence of major depression, nine (21%) current and ten (23%) pa...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/0165-0327(87)90073-5

    authors: Beitman BD,Basha I,Flaker G,DeRosear L,Mukerji V,Lamberti JW

    更新日期:1987-07-01 00:00:00

  • Prevalence and correlates of DSM-5 eating disorders in patients with bipolar disorder.

    abstract:OBJECTIVE:To determine prevalence rates and clinical correlates of current DSM-5 eating disorders in patients with bipolar disorder (BP). METHODS:Prevalence rates of current DSM-5- and DSM-IV-defined binge eating disorder (BED), bulimia nervosa (BN), and anorexia nervosa (AN) were assessed with the Eating Disorder Dia...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2015.11.010

    authors: McElroy SL,Crow S,Blom TJ,Biernacka JM,Winham SJ,Geske J,Cuellar-Barboza AB,Bobo WV,Prieto ML,Veldic M,Mori N,Seymour LR,Bond DJ,Frye MA

    更新日期:2016-02-01 00:00:00

  • A review of white matter microstructure alterations of pathways of the reward circuit in depression.

    abstract:BACKGROUND:Depressed mood, anhedonia, psychomotor retardation and alterations of circadian rhythm are core features of the depressive syndrome. Its neural correlates can be located within a frontal-striatal-tegmental neural network, commonly referred to as the reward circuit. It is the aim of this article to review lit...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,评审

    doi:10.1016/j.jad.2015.06.041

    authors: Bracht T,Linden D,Keedwell P

    更新日期:2015-11-15 00:00:00

  • Subsyndromal depression in adolescents after a brief psychotherapy trial: course and outcome.

    abstract:INTRODUCTION:Subsyndromal depression has been associated with an increased risk of the development of major depressive disorder (MDD). Since treatment trials of adolescent MDD often result in subsyndromal depression as the outcome, the long-term course of these youth would be useful to understand. METHODS:107 adolesce...

    journal_title:Journal of affective disorders

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0165-0327(00)00189-0

    authors: Brent DA,Birmaher B,Kolko D,Baugher M,Bridge J

    更新日期:2001-03-01 00:00:00

  • Investigating the potential role of BDNF and PRL genotypes on antidepressant response in depression patients: A prospective inception cohort study in treatment-free patients.

    abstract:BACKGROUND:Brain-derived neurotrophic factor (BDNF) is associated with response to antidepressant drugs in mood and anxiety disorders. Prolactin (PRL) is a pituitary hormone with behavioural effects, acting as a neurotrophic factor within the brain and may be involved in antidepressant response. OBJECTIVES:To investig...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2019.08.058

    authors: Ochi T,Vyalova NM,Losenkov IS,Levchuk LA,Osmanova DZ,Mikhalitskaya EV,Loonen AJM,Bosker FJ,Simutkin GG,Bokhan NA,Wilffert B,Ivanova SA

    更新日期:2019-12-01 00:00:00

  • Shame, pride, and suicidal ideation in a military clinical sample.

    abstract:BACKGROUND:Suicide risk among U.S. military personnel has been increasing over the past decade. Fluid vulnerability theory (FVT; Rudd, 2006) posits that acute suicidal episodes increase in severity when trait-based (e.g., shame) and state-based (e.g., hopelessness) risk factors interact, especially among individuals wh...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2012.11.006

    authors: Bryan CJ,Ray-Sannerud B,Morrow CE,Etienne N

    更新日期:2013-05-01 00:00:00

  • Costs of the principal mood disorders: a study of comparative direct and indirect costs incurred by those with bipolar I, bipolar II and unipolar disorders.

    abstract:BACKGROUND:While there have been many studies comparing direct and indirect costs engendered individually and nationally by those with unipolar (UP) and bipolar (BP) disorders, there has been no previous study comparing costs across the bipolar I (BP I) and bipolar II (BP II) disorders. METHODS:We examine direct and i...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2012.10.002

    authors: Parker G,McCraw S,Hadzi-Pavlovic D,Fletcher K

    更新日期:2013-07-01 00:00:00

  • Childhood CBCL bipolar profile and adolescent/young adult personality disorders: a 9-year follow-up.

    abstract:BACKGROUND:To assess the late adolescent psychiatric outcomes associated with a positive Child Behavior Checklist-Juvenile Bipolar Disorder Phenotype (CBCL-JBD) in children diagnosed with ADHD and followed over a 9-year period. METHODS:Parents of 152 children diagnosed as ADHD (ages 7-11 years) completed the CBCL. Nin...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2010.10.019

    authors: Halperin JM,Rucklidge JJ,Powers RL,Miller CJ,Newcorn JH

    更新日期:2011-04-01 00:00:00

  • Perinatal depression among mothers in a South African birth cohort study: Trajectories from pregnancy to 18 months postpartum.

    abstract:BACKGROUND:Perinatal depression affects 21-50% of women in South Africa and poses significant health risks to mothers and children. Trajectories of depressive symptoms change over time and have not been well characterized during the perinatal period in low and middle-income countries. METHODS:Data from women enrolled ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2019.08.052

    authors: Pellowski JA,Bengtson AM,Barnett W,DiClemente K,Koen N,Zar HJ,Stein DJ

    更新日期:2019-12-01 00:00:00

  • Clinical experience with phototherapy.

    abstract::Thirty subjects with seasonal affective disorder (SAD) and three subjects with a non-seasonal depression had a trial of phototherapy in an open assessment of the feasibility of phototherapy in clinical practice. 43% of the SAD subjects met the criteria for 'successful treatment', but none of the subjects with non-seas...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/0165-0327(90)90069-k

    authors: Stinson D,Thompson C

    更新日期:1990-02-01 00:00:00

  • Default mode network alterations in individuals with high-trait-anxiety: An EEG functional connectivity study.

    abstract:BACKGROUND:Although several researches investigated Default Mode Network (DMN) alterations in individuals with anxiety disorders, up to now no studies have investigated DMN functional connectivity in non-clinical individuals with high-trait-anxiety using quantitative electroencephalography (EEG). Here, the main aim was...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2018.12.071

    authors: Imperatori C,Farina B,Adenzato M,Valenti EM,Murgia C,Marca GD,Brunetti R,Fontana E,Ardito RB

    更新日期:2019-03-01 00:00:00

  • Depressive symptom severity mediates the association between avoidant problem-solving style and suicidal ideation.

    abstract:BACKGROUND:The contemporaneous association between avoidant style, a maladaptive social problem-solving strategy, and adolescent suicidal ideation has been well established. However, the mechanisms underlying this association are not well understood. Using cross-lagged panel modeling, the present study examined whether...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2020.05.120

    authors: López R Jr,Brick LA,Defayette AB,Whitmyre ED,Wolff J,Frazier E,Spirito A,Esposito-Smythers C

    更新日期:2020-09-01 00:00:00

  • Psychoeducation and online mood tracking for patients with bipolar disorder: A randomised controlled trial.

    abstract:BACKGROUND:Psychoeducation is an effective adjunct to medications in bipolar disorder (BD). Brief psychoeducational approaches have been shown to improve early identification of relapse. However, the optimal method of delivery of psychoeducation remains uncertain. Here, our objective was to compare a short therapist-fa...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.jad.2016.06.064

    authors: Bilderbeck AC,Atkinson LZ,McMahon HC,Voysey M,Simon J,Price J,Rendell J,Hinds C,Geddes JR,Holmes E,Miklowitz DJ,Goodwin GM

    更新日期:2016-11-15 00:00:00

  • Borderline personality disorder, but not euthymic bipolar I disorder, is associated with prolonged post-error slowing in sensorimotor performance.

    abstract:BACKGROUND:Borderline personality disorder (BPD) and bipolar disorder (BD) are common psychiatric diagnoses. Impulsivity and affective instability are prominent features of both illnesses, complicate treatment and are associated with poor clinical outcomes. Yet, little is known about sensorimotor control in these popul...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2016.03.027

    authors: Saunders KE,Goodwin GM,Rogers RD

    更新日期:2016-07-01 00:00:00

  • Economic costs of full-blown and subthreshold panic disorder.

    abstract:BACKGROUND:Data on the societal costs of mental disorders are necessary to inform health policies. METHODS:This study assessed the costs of panic disorder and subthreshold panic disorder, compared these with costs of other mental disorders, and assessed the effects of (psychiatric and somatic) comorbidity and agorapho...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2007.03.013

    authors: Batelaan N,Smit F,de Graaf R,van Balkom A,Vollebergh W,Beekman A

    更新日期:2007-12-01 00:00:00