Abstract:
BACKGROUND:The assessment of comorbid physical illness and metabolic or cardiovascular risk factors as potential risk factors for onset of major depressive disorder (MDD) is crucial. We aimed to investigate potential risk factors for the development of MDD among individuals with chronic medical conditions and metabolic and behavioral risk factors using a large population-based retrospective cohort from the data of the National Health Insurance Service (NHIS) in South Korea. METHODS:The population-based retrospective cohort included data from 2,370,815 adults (age ≥20 years) diagnosed with MDD between January 1, 2010, and December 31, 2016 and age- and gender-matched 2,370,815 healthy controls obtained from the claims data of the NHIS. The data of the regular health checkup provided by the NHIS were also included (age ≥40 years). Logistic regression analyses were performed to investigate the potential risk factors for the incidence of MDD. RESULTS:Chronic medical conditions such as Parkinson's disease (odds ratio [OR] = 7.808, 95% confidence interval [CI] = 7.517-8.11), epilepsy (OR = 6.119, 95% CI = 6.019-6.22), multiple sclerosis (OR = 5.532, 95% CI = 4.976-6.151), Huntington's disease (OR = 5.387, 95% CI = 3.258-8.909), migraine (OR = 4.374, 95% CI = 4.341-4.408), stroke (OR = 4.074, 95% CI = 4.032-4.117), and cancer; metabolic syndrome (OR = 1.049, 95% CI = 1.041-1.057) and several of its components including central obesity, elevated fasting blood glucose and triglyceride levels, and reduced high-density lipoprotein level; and cigarette smoking, frequent alcohol consumption, and low physical activity are potential risk factors for the development of MDD. CONCLUSION:Our results may support previous evidence on the association between physical conditions and the incidence of MDD as reported by individual population-based studies with modest sample sizes.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Han KM,Kim MS,Kim A,Paik JW,Lee J,Ham BJdoi
10.1016/j.jad.2019.07.003subject
Has Abstractpub_date
2019-10-01 00:00:00pages
486-494eissn
0165-0327issn
1573-2517pii
S0165-0327(19)30939-5journal_volume
257pub_type
杂志文章abstract:BACKGROUND:Postnatal depression affects a significant number of parents; however, its co-occurrence in mothers and fathers has not been studied extensively. Identifying predictors and correlates of postnatal depressive symptoms can help develop effective interventions. METHODS:Questionnaires on several socio-demograph...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2015.10.033
更新日期:2016-01-15 00:00:00
abstract:BACKGROUND:Deficits in social cognition, e.g. theory of mind (ToM) represent core characteristics involved in the etiology of psychopathological symptoms and an important predictor of social competence. In bipolar affective disorder, evidence for ToM deficits is scant, although brain imaging studies and impairments in ...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2009.08.017
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:Lack of adaptive and enhanced maladaptive coping with stress and negative emotions are implicated in many psychopathological disorders. We describe the development of a new scale to investigate the relative contribution of different coping styles to psychopathology in a large population sample. We hypothesiz...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2015.11.027
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:There is little information on the degree to which self-stigma is experienced by individuals with a diagnosis of bipolar disorder or depression across Europe. This study describes the levels of self-stigma, stigma resistance, empowerment and perceived discrimination reported in these groups. METHODS:Data we...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2010.09.001
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:Although suicide is a global public health concern with approximately one million people dying by suicide annually, our knowledge of the proximal risk mechanisms is limited. In the present study, we investigated the utility of two proximal mechanisms (goal disengagement and goal reengagement) in the predicti...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2012.04.035
更新日期:2012-12-15 00:00:00
abstract:BACKGROUND:Social network, loneliness, generalized anxiety disorder (GAD) and major depression disorder (MDD) are interrelated. However, as the directions of these associations are still unclear, we examined them prospectively using community-based data. METHODS:Data on 5066 adults aged ≥50 years from The Irish Longit...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2018.12.043
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:The risk of switching from mania to depression in bipolar disorder has been poorly studied. Large observational studies may be useful in identifying variables that predict switch to depression after mania and provide data on medication use and outcomes in "real world" patients. METHOD:EMBLEM (European Mania...
journal_title:Journal of affective disorders
pub_type: 杂志文章,多中心研究
doi:10.1016/j.jad.2009.02.007
更新日期:2009-11-01 00:00:00
abstract:BACKGROUND:Comorbid depression and type 2 diabetes (T2D) is an important risk factor for dementia. This study investigates the factors associated with, the spatial variation and spatial convergence of diagnosed cases of these conditions. This approach may identify areas with unmet needs. METHODS:We used cross-sectiona...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2020.08.032
更新日期:2020-12-01 00:00:00
abstract::The current study compares the current and lifetime prevalence of affective disorder in women who have adopted and have natural children (n = 110) with women who only have adopted children (n = 176). There was no difference in lifetime prevalence of psychiatric disorder between the two groups and a nonsignificant tren...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/0165-0327(94)00105-i
更新日期:1995-04-16 00:00:00
abstract:BACKGROUND:Lithium has been found to be effective in reducing suicide rates during long term treatment of patients with bipolar disorders. Data on the efficacy of anticonvulsant mood stabilizers in reducing suicide risk are sparse. METHOD:Charts of 140 bipolar patients treated continuously for a minimum of 6 months du...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/s0165-0327(02)00302-6
更新日期:2003-02-01 00:00:00
abstract:BACKGROUND:Throughout the past decades, several methods have been developed to achieve therapeutic lithium blood levels as quick and safe as possible. The present study will systematically review the methods developed and studied for lithium dose estimation or level prediction at the initiation of therapy. METHODS:A s...
journal_title:Journal of affective disorders
pub_type: 杂志文章,评审
doi:10.1016/j.jad.2012.08.013
更新日期:2013-03-20 00:00:00
abstract:BACKGROUND:Patients with bipolar disorder (BD) present widespread and significant neurocognitive impairments during all stages of the disorder. Repetitive transcranial magnetic stimulation (rTMS) has been used to improve clinical outcomes in common psychiatric diseases, such as depression, anxiety disorders, schizophre...
journal_title:Journal of affective disorders
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jad.2018.12.102
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:Poor micro-scale environmental features, such as graffiti and broken windows, have been associated with crime and signs of social disorder with a potential impact on mental health. The aim of this study is to investigate the association between micro-scale environment and mental health problems in later life...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2017.05.001
更新日期:2017-08-15 00:00:00
abstract:BACKGROUND:Ketamine appears to have a therapeutic role in certain mental disorders, most notably depression. However, the comparative performance of different formulations of ketamine is less clear. OBJECTIVES:This study aimed to assess the comparative efficacy and tolerability of racemic and esketamine for the treatm...
journal_title:Journal of affective disorders
pub_type: 杂志文章,评审
doi:10.1016/j.jad.2020.09.071
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Affective symptoms in Alzheimer's disease (AD) can be rated with both informant- and self-ratings. Information from these two modalities may not converge. We estimated network structures of affective symptoms in AD with both rating modalities and assessed the longitudinal stability of the networks. METHODS:...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2020.07.100
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVE:To evaluate the efficacy of gabapentin as an adjunctive treatment for bipolar disorder in both depressed and manic phases. METHOD:Thirty seven patients with bipolar type I or II with or without a rapid cycling course were openly treated with gabapentin added to current treatment for up to six months. Mood sy...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/s0165-0327(98)00192-x
更新日期:1999-09-01 00:00:00
abstract:BACKGROUND:There are several lines of evidence implicating a glial abnormality in the pathophysiology of bipolar disorder. Previous studies have reported a wide range of abnormalities but with little consistency between their findings. METHODS:Sixty frozen postmortem temporal cortical brain samples from normal, schizo...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2005.08.015
更新日期:2006-03-01 00:00:00
abstract:BACKGROUND:Optimal long-term treatment of major depression should assess the background factors affecting remission and recurrent episodes. The duration and number of previous depressive episodes has been shown to be important for recurrence. This long-term prospective study of patients with major depression assessed t...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/s0165-0327(00)00260-3
更新日期:2001-08-01 00:00:00
abstract::The proportion of patients with a fall-winter pattern of feeling worst comparable to that of patients with seasonal affective disorder (SAD) was 11.4% in our sample of major depressed inpatients. Since admission to psychiatric inpatient services is influenced to an unknown extent by various factors it is not possible ...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/0165-0327(90)90101-d
更新日期:1990-08-01 00:00:00
abstract:BACKGROUND:Adolescence is typified by increasing rates of substance use and the development of substance use disorders (SUD). Aberrant connectivity between cortical regions involved in executive control, and subcortical regions has been suggested to be associated with SUD and problematic substance use among adolescents...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2020.10.051
更新日期:2021-01-15 00:00:00
abstract::Previous studies have demonstrated reduced function of peripheral beta-adrenoreceptors in panic disorder with agoraphobia (PDA). We recently reported that decreased lymphocyte beta-receptor function was associated with milder agoraphobia and better treatment response in PDA. We now report on lymphocyte beta-receptor f...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/0165-0327(93)90115-z
更新日期:1993-09-01 00:00:00
abstract:BACKGROUND:Results from short-term treatment studies have demonstrated the efficacy of antidepressant medications for outpatients with early-onset chronic depression. However, scant data exists regarding the long-term outcome of these patients treated for this disorder. METHODS:The author conducted a one-year naturali...
journal_title:Journal of affective disorders
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0165-0327(98)00040-8
更新日期:1999-07-01 00:00:00
abstract:INTRODUCTION:Subsyndromal depression has been associated with an increased risk of the development of major depressive disorder (MDD). Since treatment trials of adolescent MDD often result in subsyndromal depression as the outcome, the long-term course of these youth would be useful to understand. METHODS:107 adolesce...
journal_title:Journal of affective disorders
pub_type: 临床试验,杂志文章
doi:10.1016/s0165-0327(00)00189-0
更新日期:2001-03-01 00:00:00
abstract:BACKGROUND:The purposes of this paper are to determine the prevalence of distress in the community, to identify its determinants and to assess its relationship to somatic conditions and subjective well being. METHODS:Distress and associated factors were investigated in a random sample of 5000 participants (35-74 years...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2010.10.041
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND:Subjective experience of illness affects outcomes among populations with bipolar disorder (BD). This cross-sectional study combined qualitative and quantitative approaches to evaluate perceived treatment effects, concerns and expectations among 90 individuals with BD. METHODS:Adults with Type I BD, mean age...
journal_title:Journal of affective disorders
pub_type: 杂志文章,多中心研究
doi:10.1016/j.jad.2008.10.002
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND:Increased motor activity is a cardinal feature of the mania of Bipolar Disorder (BD), and is thought to reflect dopaminergic dysregulation. Motor activity in BD has been studied almost exclusively with self-report and observer-rated scales, limiting the ability to objectively quantify this behavior. We used ...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2009.04.018
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Pre-treatment sleep disturbance has been shown to predict antidepressant treatment outcomes. How changes in sleep disturbance during acute treatment affect longitudinal outcomes, or whether continuation-phase treatment further improves sleep disturbance, is unclear. METHODS:We assessed sleep disturbance rep...
journal_title:Journal of affective disorders
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jad.2019.10.033
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVE:Depressive symptoms are associated with inflammation yet the association between inflammation and different levels of depression remains unclear. Therefore, we studied the association of subsyndromal and depressive symptoms with inflammatory markers in a large multi-ethnic cohort. METHODS:C-reactive protein ...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2014.04.018
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:Although recent neuroimaging studies have suggested that functional deficits in facial perception are associated with panic disorder (PD), the possibility of cortical thickness and perfusion abnormalities have not been studied in patients with PD. We aimed to investigate alterations in cortical thickness and...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2020.07.139
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:The functional outcome of Bipolar Disorder (BD) is highly variable. This variability has been attributed to multiple demographic, clinical and cognitive factors. The critical next step is to identify combinations of predictors that can be used to specify prognostic subtypes, thus providing a basis for a stag...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2012.06.005
更新日期:2013-01-10 00:00:00