Abstract:
BACKGROUND:Patients with bipolar disorder (BD) present widespread and significant neurocognitive impairments during all stages of the disorder. Repetitive transcranial magnetic stimulation (rTMS) has been used to improve clinical outcomes in common psychiatric diseases, such as depression, anxiety disorders, schizophrenia, and BD. Whether rTMS can improve cognitive function in BD patients remains unclear. The present study explored the regulatory effects of rTMS on cognitive function in patients with BD. METHODS:Fifty-two eligible subjects with BD were randomly assigned to receive active or sham rTMS via high-speed magnetic stimulator with a figure-of-eight coil for 10 consecutive days. In the active rTMS group, a total of 25,000 stimuli were applied over the left dorsolateral prefrontal cortex at 110% of the motor threshold. The sham group received corresponding sham stimulation. Clinical manifestations and cognitive functions were assessed using a modified 24-item Hamilton Depression Rating Scale (HDRS), the Young Mania Rating Scale (YMRS), and the MATRICS Consensus Cognitive Battery (MCCB). RESULTS:Ten consecutive days of high-frequency active rTMS improved scores on the Wechsler Memory Scale-III Spatial Span, and the MCCB Category Fluency subtest, without intolerable adverse effects. No significant differences in HDRS or YMRS scores were found between groups. LIMITATIONS:No follow-up after the intervention. The effect of the drug on cognitive function in subjects was not excluded. CONCLUSIONS:Short-term rTMS can improve cognitive function in BD patients.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Yang LL,Zhao D,Kong LL,Sun YQ,Wang ZY,Gao YY,Li N,Lu L,Shi L,Wang XY,Wang YMdoi
10.1016/j.jad.2018.12.102subject
Has Abstractpub_date
2019-03-01 00:00:00pages
851-856eissn
0165-0327issn
1573-2517pii
S0165-0327(18)31710-5journal_volume
246pub_type
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