Abstract:
BACKGROUND:Comorbid depression and type 2 diabetes (T2D) is an important risk factor for dementia. This study investigates the factors associated with, the spatial variation and spatial convergence of diagnosed cases of these conditions. This approach may identify areas with unmet needs. METHODS:We used cross-sectional data (2010 to 2014) from 16 general practices in west Adelaide, Australia. Multi-level modelling accounting for individual-level characteristics nested within statistical area level 1 (SA1) determined covariate associations with these three diseases. Getis-Ord Gi method was used to investigate spatial variation, hot spots and cold spots of these conditions. RESULTS:1.4% of active patients in west Adelaide aged 45 and above were diagnosed with dementia, 9.6% with depression and 13.3% with T2D. Comorbidity was significant across all three diseases. Elderly age (65+ years) was significantly associated with diagnosed dementia and T2D. Hyperlipidemia or hypertension diagnosis and belonging to lower socioeconomic status were significantly associated with diagnosed T2D and depression. The spatial distribution of each disease varied across west Adelaide. Spatial convergence of the three diseases was observed in two large hot spot clusters and one main cluster of cold spots. LIMITATIONS:Due to underreporting, potentially significant covariates like alcohol intake were unable to be assessed. There may be a bias towards health-conscious individuals or patients managing diagnosed diseases that actively visit their general practice. CONCLUSIONS:Patterns of spatial convergence and the shared associations in dementia, depression and diabetes enable policymakers to tailor interventions to the areas where risk of these conditions are greater.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Aw JYH,Smurthwaite K,Bagheri Ndoi
10.1016/j.jad.2020.08.032subject
Has Abstractpub_date
2020-12-01 00:00:00pages
524-530eissn
0165-0327issn
1573-2517pii
S0165-0327(20)32628-8journal_volume
277pub_type
杂志文章abstract:BACKGROUND:Each year, almost 35% of children are exposed to maternal depression and more grow up in persistent poverty, increasing the risk for stress-related disease and other socio-developmental deficits later in life. These impacts are likely related to chronic stress via the hypothalamic-pituitary-adrenal (HPA) axi...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2020.07.053
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:Serotonin transporter (SERT) binding is decreased in lymphocytes of depression patients and this decrease is partially reversed by antidepressant medication. However, recent evidence has shown that clustering of SERT on cell membranes is very important for receptor functionality. Alteration in SERT clusterin...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2011.12.041
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abstract:BACKGROUND:Few prospective studies examine the link between lower heart rate variability (HRV) and depression symptoms in adolescents. A recent animal model specifically links HRV to anhedonia, suggesting a potential translational model for human research. METHOD:We investigated the association between spectral measur...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2016.02.040
更新日期:2016-05-15 00:00:00
abstract::Two hundred thirty-seven (237) manic patients diagnosed by DSM-III-R criteria as either purely manic (204) or mixed bipolar (33) were reviewed for analysis of the diagnostic performance of the DSM-III-R criteria required to diagnose the mixed bipolar state. We calculated the sensitivity, specificity, positive predicti...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/s0165-0327(97)00084-0
更新日期:1997-10-01 00:00:00
abstract:BACKGROUND:The experience of social exclusion (ostracism) is linked to the etiology and maintenance of depression. Most individuals experience emotional stress in states of social exclusion. Insecurely attached individuals, especially with an unresolved trauma, show maladaptive coping in response to social stress. The ...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2016.12.030
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:This study aims to examine associations between serum 25-hydroxyvitamin D [25(OH)D] concentrations and depressive symptoms in an older Korean population. METHODS:The study used data from the Korean Urban Rural Elderly study, which enrolled 2942 participants aged 65 years or older from urban and rural commun...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2015.09.043
更新日期:2016-01-01 00:00:00
abstract:INTRODUCTION:Altered levels of acute-phase proteins are often described in different conditions in BD. Nevertheless, data on the association between lithium treatment and inflammatory markers in the long-term course of BD are still missing. The aim of the study was to examine the long-term course of BD concerning long-...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2020.11.063
更新日期:2021-02-15 00:00:00
abstract:BACKGROUND:Acute administration of subanesthestic doses of intravenous ketamine have been shown to elicit a rapid antidepressant response in patients with treatment-resistant depression. However, it remains to be seen if repeated doses over a longer period of time will have the same effects. Here, we assess the long-te...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2012.10.015
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:The Patient Health Questionnaire-9 (PHQ-9) and the Generalized Anxiety Disorder (GAD-7) are two widely used instruments to screen patients for depression and anxiety. Comparable psychometric properties across different demographic and linguistic groups are necessary for multiple group comparison and internat...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2019.10.035
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:The maternity blues have been studied world-wide and are generally regarded as a cross-cultural phenomenon. However, low prevalence rates of the blues have been reported recently in studies of Japanese women. The purposes of this study are, firstly, to establish whether the low prevalence noted in Japanese w...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/s0165-0327(02)00039-3
更新日期:2003-07-01 00:00:00
abstract::Depression-related cognitive impairment (DRCI) is a condition which despite its initial treatment response, shows a progressive deterioration. No consistent therapeutic strategies have been proposed to combat this condition. This may be due to a reluctance to treat the cognitively impaired, a failure to recognise the ...
journal_title:Journal of affective disorders
pub_type: 杂志文章,评审
doi:10.1016/0165-0327(95)00070-4
更新日期:1996-01-22 00:00:00
abstract:OBJECTIVE:We wished to examine whether resilience might be a protective factor in relation to suicidal behavior. METHOD:To do this resilience was examined in relation to childhood trauma, a well established risk factor for suicidal behavior, in two samples. In a preliminary sample 20 abstinent substance abuse patients...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2011.05.006
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:Several studies have assessed the association between genetic polymorphisms of tryptophan hydroxylase (TPH1) and risk of mood disorders and alcohol dependence, with controversial results. Our aim was to assess the association of TPH1 A218C polymorphism (rs1800532) with mood disorders, including major depress...
journal_title:Journal of affective disorders
pub_type: 杂志文章,meta分析
doi:10.1016/j.jad.2011.04.018
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:The risk of switching from mania to depression in bipolar disorder has been poorly studied. Large observational studies may be useful in identifying variables that predict switch to depression after mania and provide data on medication use and outcomes in "real world" patients. METHOD:EMBLEM (European Mania...
journal_title:Journal of affective disorders
pub_type: 杂志文章,多中心研究
doi:10.1016/j.jad.2009.02.007
更新日期:2009-11-01 00:00:00
abstract:BACKGROUND:Transcranial magnetic stimulation (TMS) of the dorsolateral prefrontal cortex is a brain stimulation technique widely used to treat depression. BDNF serum concentrations have been shown to be decreased in patients with major depressive disorder and can be upregulated by several antidepressive treatment strat...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2007.08.008
更新日期:2008-04-01 00:00:00
abstract::The two diagnostic Newcastle Scales for depression have been evaluated in a drug trial with antidepressants. By use of latent structure analysis (Rasch models) it was found that two dimensions are necessary for describing the diagnosis of depression, one for endogenous features and one for reactive features. Of the de...
journal_title:Journal of affective disorders
pub_type: 临床试验,杂志文章
doi:10.1016/0165-0327(88)90059-6
更新日期:1988-03-01 00:00:00
abstract:BACKGROUND:Stress-induced failed resilience of brain plasticity can contribute to the onset and recurrence of depression. Chronic stress has been reported to open windows of epigenetic plasticity in hippocampus. However, how hippocampal plasticity underlies depression-like behaviors and how it adapts in response to str...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2017.10.019
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Misophonia is a psychiatric disorder in which ordinary human sounds like smacking or chewing provoke intense anger and disgust. Despite the high burden of this condition, to date there is no evidence-based treatment available. In this study we evaluated the efficacy of cognitive behavioral therapy (CBT) and ...
journal_title:Journal of affective disorders
pub_type: 临床试验,杂志文章
doi:10.1016/j.jad.2017.04.017
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:To identify bipolar disorder during the initial stages of a depressive episode has always been a great clinical challenge. Patterns of functional brain activity may underlie the differences in the neural mechanisms of bipolar depression (BD) and unipolar depression (UD). This study aimed to investigate the d...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2017.07.031
更新日期:2018-01-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/0165-0327(85)90096-5
更新日期:1985-09-01 00:00:00
abstract:BACKGROUND:The aim of this study was to analyze the impact of pretreatment characteristics and personality disorders on the onset of response in the treatment of panic disorder. METHODS:The data of 73 out-patients with panic disorder who had completed at least 6 weeks of a randomized trial of 24 weeks of either paroxe...
journal_title:Journal of affective disorders
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/S0165-0327(03)00043-0
更新日期:2004-05-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2017.12.019
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:Asylum seekers show high prevalence of depressive disorders compared to native populations. For the assessment of depression, the Patient Health Questionnaire-9 (PHQ-9) is a widely used instrument that has shown high validity and reliability. However, it is largely unknown whether PHQ-9 scores are comparable...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2019.11.055
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Social networking sites like Facebook represent a potentially valuable means for individuals with low self-esteem or interpersonal difficulties to connect with others; however, recent research indicates that individuals who are most in need of social benefits from Facebook may be ineffective in their communi...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2013.06.038
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:China's HIV epidemic commenced in its agrarian provinces through contaminated commercial plasma donation centers and is now becoming a public health concern nationwide. Little is known of the psychiatric and substance use disorder characteristics of this population, or their impact on everyday function, empl...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2010.10.039
更新日期:2011-05-01 00:00:00
abstract:INTRODUCTION:Studies focusing on anxiety temporal patterns and cortisol activity in older adults are scarce. The objectives of this study were to examine in older adults the relationship between anxiety temporal patterns and cortisol activity and ascertain the presence of sex differences. METHODS:Data were retrieved f...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2020.08.020
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Alexithymia is a problem of emotion regulation and for this reason alone may relate to suicidality. This article investigates the evidence for a direct relationship. It explores the possibility of an additional role for interoception in future research. METHODS:A scoping review of peer-reviewed journal arti...
journal_title:Journal of affective disorders
pub_type: 杂志文章,评审
doi:10.1016/j.jad.2018.06.027
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate whether a different pattern of HPA axis activity is found between children with social phobia (SP) and healthy control children. METHODS:A total of 50 prepubertal subjects (25 children with SP and 25 healthy control subjects) were studied. The effects of stress were ...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2008.03.006
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND:Altered reward and punishment function has been suggested as an important vulnerability factor for the development of Major Depressive Disorder (MDD). Prior ERP studies found evidence for neurophysiological dysfunctions in reinforcement processes in adults with MDD. To date, only few ERP studies have examine...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2018.01.017
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVE:The frontal-limbic circuit is hypothesized as sub-serving emotional regulation. We performed whole brain resting-state functional connectivity (rs-FC) analysis by studying the key hubs of frontal-limbic circuit: anterior cingulate cortex (ACC), bilateral insula subregions, bilateral amygdala (Amy) as seeds, s...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2020.05.005
更新日期:2020-09-01 00:00:00