Abstract:
BACKGROUND:Genetic studies have been consistent that bipolar disorder type I (BPI) runs in families and that this familial aggregation is strongly influenced by genes. In a preliminary study, we proved that anxiety trait meets endophenotype criteria for BPI. METHODS:We assessed 619 individuals from the Central Valley of Costa Rica (CVCR) who have received evaluation for anxiety following the same methodological procedure used for the initial pilot study. Our goal was to conduct a multipoint quantitative trait linkage analysis to identify quantitative trait loci (QTLs) related to anxiety trait in subjects with BPI. We conducted the statistical analyses using Quantitative Trait Loci method (Variance-components models), implemented in Sequential Oligogenic Linkage Analysis Routines (SOLAR), using 5606 single nucleotide polymorphism (SNPs). RESULTS:We identified a suggestive linkage signal with a LOD score of 2.01 at chromosome 2 (2q13-q14). LIMITATIONS:Since confounding factors such as substance abuse, medical illness and medication history were not assessed in our study, these conclusions should be taken as preliminary. CONCLUSIONS:We conclude that region 2q13-q14 may harbor a candidate gene(s) with an important role in the pathophysiology of BPI and anxiety.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Contreras J,Hare E,Chavarría-Soley G,Raventós Hdoi
10.1016/j.jad.2017.12.019subject
Has Abstractpub_date
2018-07-01 00:00:00pages
105-108eissn
0165-0327issn
1573-2517pii
S0165-0327(17)32007-4journal_volume
234pub_type
杂志文章abstract:BACKGROUND:Several lines of evidence are pointing towards an involvement of the vascular endothelial growth factor (VEGF) in the pathophysiology of depression. There are studies analyzing blood levels of VEGF in patients with depression compared to controls, but a data on cerebrospinal fluid (CSF) levels of VEGF in pat...
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journal_title:Journal of affective disorders
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journal_title:Journal of affective disorders
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journal_title:Journal of affective disorders
pub_type: 杂志文章,评审
doi:10.1016/j.jad.2014.07.002
更新日期:2014-10-01 00:00:00
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journal_title:Journal of affective disorders
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更新日期:2020-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.jad.2011.10.002
更新日期:2012-02-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章,评审
doi:10.1016/j.jad.2020.01.124
更新日期:2020-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0165-0327(80)90001-4
更新日期:1980-09-01 00:00:00
abstract:BACKGROUND:Prevention of recurrence is a challenge in the management of major depressive disorder (MDD). The long-term effects of Preventive Cognitive Therapy (PCT) in preventing recurrence in MDD are not known. METHODS:A RCT comparing the addition of PCT to Treatment As Usual (TAU), versus TAU including patients with...
journal_title:Journal of affective disorders
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jad.2015.06.048
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Depression in pregnancy is a serious health issue; however, anxiety in pregnancy, with a reported higher prevalence, may also be a serious issue. Anxiety symptoms in pregnancy can relate to several anxiety types, such as general anxiety, anxiety disorders, and pregnancy-related anxiety (PrA), anxiety charact...
journal_title:Journal of affective disorders
pub_type: 杂志文章,评审
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journal_title:Journal of affective disorders
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doi:10.1016/j.jad.2020.12.123
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journal_title:Journal of affective disorders
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2020.04.060
更新日期:2020-08-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2013.07.039
更新日期:2014-01-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2015.11.006
更新日期:2016-01-15 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2014.11.028
更新日期:2015-03-15 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2020.03.046
更新日期:2020-06-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0165-0327(95)00075-5
更新日期:1996-04-12 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2008.01.017
更新日期:2008-09-01 00:00:00