Abstract:
BACKGROUND:Epidemiological and clinical studies have reported the frequent co-occurrence of social phobia (SP) and alcohol use disorders. Patients with SP often use alcohol to cope with the social situations they fear, and to lessen anticipatory anxiety, behavioral inhibition, and phobic avoidance. We investigated whether the presence of lifetime comorbidity with alcohol abuse was associated with significant differences as regards demographic and clinical features, family history and pattern of comorbidity in a large clinical sample of SP outpatients. METHOD:The sample comprised 153 outpatients who met DSM-III-R diagnostic criteria for SP. Demographic, family history and course characteristics were investigated by a semi-structured interview. Social phobic symptoms and the severity of the illness have been assessed by the Liebowitz Social Anxiety Scale (LSAS) and the Liebowitz Social Phobic Disorders Rating Scale, Severity (LSPDRS). Patients completed the Hopkins Symptom Checklist (HSCL 90). RESULTS:Thirty-four patients (22.2%) had a past or current history of alcohol abuse for at least 1 year. There were no significant differences between these patients and those without a history of alcohol abuse, as regards demographic features and lifetime comorbidity with major depression and other anxiety disorders. Bipolar disorder type II was found almost exclusively among patients with alcohol abuse, as well as family history for bipolar disorders. LIMITATIONS:Retrospective study. CONCLUSIONS:Our data indicate a strong relationship between bipolar II disorder and alcohol abuse comorbidity in patients with SP. The socializing and disinhibiting effect that many social phobics report might be mediated by mood elation induced by alcohol. The presence of bipolar diathesis in patients presenting with social anxiety might explain their increased susceptibility to alcohol, as they might undertake alcohol abuse as an attempt to overcome social difficulties.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Perugi G,Frare F,Madaro D,Maremmani I,Akiskal HSdoi
10.1016/s0165-0327(00)00316-5subject
Has Abstractpub_date
2002-02-01 00:00:00pages
33-9issue
1eissn
0165-0327issn
1573-2517pii
S0165032700003165journal_volume
68pub_type
杂志文章abstract:BACKGROUND:INN 00835 is a synthetic pentapeptide with a potential for rapid onset of action as an antidepressant. Its efficacy was investigated in a pilot study in patients diagnosed with major depression. METHODS:Fifty two patients received either active drug - INN 00835 (26 patients) - or placebo (26 patients), subc...
journal_title:Journal of affective disorders
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0165-0327(99)00187-1
更新日期:2000-12-01 00:00:00
abstract::Background Real-time functional magnetic resonance imaging neurofeedback (rtfMRI-nf) have recently attracted attention as a novel, individualized treatment method for major depressive disorder (MDD). In this study, the antidepressant effect of neurofeedback training for left dorsolateral prefrontal cortex (DLPFC) acti...
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更新日期:2020-06-15 00:00:00
abstract:BACKGROUND:Suicide attempts have been associated to both Major Depression and Borderline Personality Disorder. This report hypothesized that there would be significant clinical differences between psychiatric outpatients with Major Depression, Major Depression with a history of a suicide attempt (but low Borderline tra...
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更新日期:1998-05-01 00:00:00
abstract:OBJECTIVES:The validity of schizoaffective disorder (SA) diagnosis has for long been a matter of controversy and its delineation from bipolar I disorders (BD) has often been questioned. However, most studies have been conducted in chronic samples and have therefore been biased towards patients with poorer outcome, whic...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2010.04.001
更新日期:2010-10-01 00:00:00
abstract::Among 231 manic-depressive patients, 18 (7.8%) had a first- or second-degree relative who had committed suicide. There were no significant differences between the unipolar or bipolar patients for a family history of suicide. The literature is reviewed and the possible implications discussed. ...
journal_title:Journal of affective disorders
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更新日期:1985-03-01 00:00:00
abstract:BACKGROUND:The aim of the research was to assess the consensus of clinicians about the appropriate treatments for depression and anxiety in youth, to discover any major differences between clinicians' beliefs and those of young people and their parents, and to assess whether clinicians' beliefs were consistent with cli...
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pub_type: 杂志文章
doi:10.1016/j.jad.2008.02.021
更新日期:2008-12-01 00:00:00
abstract::Nine-month outcome data of a randomized controlled out-patient trial of cognitive-behavioural treatment (CBT) for children and adolescents with depression are presented. CBT was compared with a non-focussed intervention (NFI) in 56 subjects. At 9 months after thr termination of the trial, 21 children (37.5%) fulfilled...
journal_title:Journal of affective disorders
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1996-09-09 00:00:00
abstract:BACKGROUND:Our aim was to determine whether there is a relationship between serum brain-derived neurotrophic factor (BDNF) and postpartum depression (PPD) in a cohort Chinese population. METHODS:From May 1, 2014, to September 30, 2014, all eligible women not on medication for depression giving birth at the Fourth Affi...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2016.04.002
更新日期:2016-08-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2011.06.024
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:In this post-hoc analysis, rates of remission and recovery were evaluated in patients with bipolar depression treated with lurasidone. METHODS:Outpatients meeting DSM-IV-TR criteria for bipolar I depression, were randomized to 6 weeks of once-daily, double-blind treatment with lurasidone 20-60mg, lurasidone...
journal_title:Journal of affective disorders
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jad.2015.07.033
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Little is known about the early phases of bipolar disorders (BPAD) and most of current knowledge derives from putative "high-risk" studies conducted in populations of bipolar off-spring; such information may therefore be relevant only to a sub-group of at-risk subjects. METHODS:Retrospective assessment of t...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2009.12.021
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:The Edinburgh Postnatal Depression Scale (EPDS) was developed as a uni-dimensional measure of depression, however there is evidence that it also measures anxiety. This study examined the factor structure of the EPDS and validity of the identified subscales. METHOD:309 women with infants aged up to 12 months...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2009.02.004
更新日期:2009-11-01 00:00:00
abstract:BACKGROUND:Emotional and cognitive functioning have been involved in insomnia etiology, and sleep disturbances are closely related to psychiatric disorders and personality traits. This study investigates the association of temperament with subjective sleep parameters. METHODS:In this web-survey, 5129 subjects (25.3% m...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2010.06.014
更新日期:2011-01-01 00:00:00
abstract::Daytime plasma cortisol levels in four rapid cycling bipolar affective disorder patients were measured longitudinally over multiple affective episodes, and changes in levels with mood state assessed for each individual patient. While three of the four patients had, as expected, increased cortisol levels during depress...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/0165-0327(87)90054-1
更新日期:1987-01-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
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更新日期:2021-02-15 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2007.03.007
更新日期:2007-06-01 00:00:00
abstract:BACKGROUND:In a population of patients with manic and mixed mood episodes, olanzapine has proven effective in maintaining response, as compared to placebo. Whether this is true for the subpopulation of patients with a mixed index episode is not known. METHODS:Post-hoc analyses were conducted on data from patients pres...
journal_title:Journal of affective disorders
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jad.2008.11.003
更新日期:2009-07-01 00:00:00
abstract::To compare mortality in bipolar and unipolar manic-depressive patients, 2168 manic-depressive first admissions reported to the Danish Psychiatric Central Register were divided into a bipolar group (19%), i.e., patients with at least one admission for mania during an average observation period of six years, and a unipo...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/0165-0327(86)90074-1
更新日期:1986-11-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
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更新日期:2012-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.jad.2009.08.016
更新日期:2009-12-01 00:00:00
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pub_type: 杂志文章
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abstract:BACKGROUND:Extensive research on impulsive suicide attempts, but lack of agreement on the use of this term indicates the need for a systematic literature review of the area. The aim of this review was to examine definitions and likely correlates of impulsive attempts. METHODS:A search of Medline, Psychinfo, Scopus, Pr...
journal_title:Journal of affective disorders
pub_type: 杂志文章,评审
doi:10.1016/j.jad.2014.08.044
更新日期:2015-01-15 00:00:00
abstract:BACKGROUND:Rates of relapse and predictive relapse factors were studied over more than 4 years in a sample of Spanish outpatients with DSM-III-R criteria for unipolar major depressive episode. METHODS:A final sample of 139 outpatient was followed monthly in a naturalistic study. The Structured Clinical Interview for D...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2003.11.008
更新日期:2004-10-15 00:00:00
abstract:BACKGROUND:Lithium is still regarded as a cornerstone for the long-term treatment of bipolar disorder. The best response to lithium is associated with clinical features of episodic clinical course, complete remission, bipolar family history and low psychiatric comorbidity. However, a specific personality profile for th...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2012.07.028
更新日期:2013-02-20 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2019.02.041
更新日期:2019-04-15 00:00:00
abstract:BACKGROUND:The aim of this study was to explore the prospective relationship between depressive symptoms and anxiety across pregnancy and the early postpartum. METHODS:Participants (N=207) completed the State-Trait Anxiety Inventory Trait subscale, Beck Depression Inventory, and social support and sleep quality measur...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2008.06.002
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:There is evidence that both a past history of psychiatric illness and insecure attachment put women at risk for mood disturbances in the postpartum period. The aim of this study was to ascertain whether maternal insecure attachment is a risk factor for mood symptoms in the immediate postpartum period indepen...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2017.01.039
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:Major depressive disorder (MDD) and bipolar disorder (BP) are two different types of mood disorders, sometimes difficult to distinguish from their depressive symptoms, and for which repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex (DLPFC) has been proposed to treat re...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2015.04.029
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:Depression treatment by General Practitioners (GPs) and patient outcomes improved significantly after a comprehensive 20-h training program of GPs. This study examines whether the effects on patient outcomes are caused by the improvements in the process of care. METHODS:Seventeen GPs participated in the tra...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/S0165-0327(03)00074-0
更新日期:2004-06-01 00:00:00
abstract:OBJECTIVE:This paper examined sex differences in the short-term course of depression and assessed the impact of possibly outcome-affecting factors, including sex-specific recall artefacts and demographic and clinical characteristics. METHODS:A cohort of 179 unipolar depressed inpatients was followed up 1 (T1) and 7 mo...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/s0165-0327(99)00035-x
更新日期:1999-12-01 00:00:00