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Prognostic factors determining response to antidepressant drugs in psychiatric out-patients and general practice.

Abstract：

:The outcome of antidepressant drug treatment was measured in 200 patients, 145 seen in psychiatric out-patient clinics and 55 in general practice, after 4 weeks of therapy. The results of the 200 patients taken together suggested that prognosis was largely determined by factors dependent on the natural history of the disorder and that clinical symptoms were unimportant, but when the results for patients in each drug group were analysed separately symptoms were more important than natural history factors. We conclude that clinical symptoms are only important predictors of response to antidepressant drugs when the patients studied are homogeneous with regard to natural history factors, particularly duration of illness.

journal_name

J Affect Disord

journal_title

Journal of affective disorders

authors

Tyrer PJ,Lee I,Edwards JG,Steinberg B,Elliott EJ,Nightingale JH

doi

10.1016/0165-0327(80)90001-4

subject

Has Abstract

pub_date

1980-09-01 00:00:00

pages

149-56

issue

3

eissn

0165-0327

issn

1573-2517

pii

0165-0327(80)90001-4

journal_volume

2

pub_type

杂志文章

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