Abstract:
BACKGROUND:Rates of relapse and predictive relapse factors were studied over more than 4 years in a sample of Spanish outpatients with DSM-III-R criteria for unipolar major depressive episode. METHODS:A final sample of 139 outpatient was followed monthly in a naturalistic study. The Structured Clinical Interview for DSM-III-R was used. Phases of evolution were recorded using the Hamilton Depression Rating Scale, applying the Frank criteria. Survival analysis, Kaplan-Meier product limit and proportional hazards models were used. RESULTS:A higher rate of relapses was observed in the partial remission group (91.4%) compared to the complete remission one (51.3%). The four factors with predictive relapse value were: "partial remission versus complete remission", "the intensity of clinical symptoms", "the age" and "the number of previous depressive episodes". The existence of partial remission was the most powerful predictive factor. LIMITATIONS:The decreasing sample size during the follow-up and the difficulty in warranting the treatment compliance. CONCLUSIONS:At medium term, relapse rates for a major depressive episode are high. Partial remission after a depressive episode seems to be an important predictive factor for relapses in a 4-year follow-up. CLINICAL RELEVANCE:Not reaching complete remission is a strong risk factor for relapses in a 4-year follow up study.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Pintor L,Torres X,Navarro V,Matrai S,Gastó Cdoi
10.1016/j.jad.2003.11.008subject
Has Abstractpub_date
2004-10-15 00:00:00pages
291-6issue
2eissn
0165-0327issn
1573-2517pii
S0165032703003240journal_volume
82pub_type
杂志文章abstract:BACKGROUND:There is a paucity of research on the distinguishing features of double depression, particularly in older adults. Preliminary studies have revealed that individuals with double depression diagnoses tend to have more severe depression than individuals with major depression or dysthymia alone, but few other di...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2005.03.019
更新日期:2007-08-01 00:00:00
abstract::The accumulation of histamine into blood platelets of depressed patients, lithium-treated patients and controls was determined using radio-labelled histamine. All groups had significantly different mean accumulation rates: the depressives had the lowest, the controls had the highest while the lithium-treated patients ...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/0165-0327(84)90033-8
更新日期:1984-10-01 00:00:00
abstract:BACKGROUND:Comorbidity between Substance Use Disorders (SUDs) and major depression is highly prevalent. This systematic review and meta-analysis aimed to estimate the prevalence of SUDs in subjects diagnosed with a major depressive disorder (MDD) in community, inpatient and outpatient settings. METHODS:A comprehensive...
journal_title:Journal of affective disorders
pub_type: 杂志文章,评审
doi:10.1016/j.jad.2020.01.141
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Vagus nerve stimulation (VNS) is a new therapy option for treatment of otherwise therapy-refractory major depressive disorder. However, the mechanism of central nervous action is poorly understood. Electroencephalographic (EEG) studies may be of interest since chronic peripheral current application to the va...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2006.10.005
更新日期:2007-06-01 00:00:00
abstract:OBJECTIVE:Electroconvulsive therapy (ECT) is an effective mode of treatment--especially for severe depression and for depression refractory to pharmacotherapy, nevertheless the mode of action of ECT is far from being fully understood. This study assessed the effects of a series of ECT in depressive subjects on cerebral...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2012.07.034
更新日期:2013-04-05 00:00:00
abstract:BACKGROUND:Concerns have been expressed about the reliability and validity of the DSM-IV criteria for schizoaffective disorder, but no systematic study has been published up to now. METHODS:The Cohen's kappa for the individual items of the DSM-IV definition of schizoaffective disorder, manic episode and major depressi...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/s0165-0327(99)00059-2
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:Epidemiological and clinical studies have reported the frequent co-occurrence of social phobia (SP) and alcohol use disorders. Patients with SP often use alcohol to cope with the social situations they fear, and to lessen anticipatory anxiety, behavioral inhibition, and phobic avoidance. We investigated whet...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/s0165-0327(00)00316-5
更新日期:2002-02-01 00:00:00
abstract:INTRODUCTION:The depressive symptoms of bipolar disorder impact health-related quality of life, quality of sleep and functioning. The BOLDER I and II trials demonstrated that quetiapine significantly improves depressive symptoms in patients with acute bipolar depression. Post-hoc analysis of the BOLDER I and II data pe...
journal_title:Journal of affective disorders
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jad.2008.06.019
更新日期:2008-12-01 00:00:00
abstract::The clinical features of 104 patients admitted to a mother and baby unit over a 5-year period with RDC diagnoses of depression or schizoaffective depression were studied by self-ratings, measurements of non-verbal behaviour from standardised videotaped interviews, and observer ratings based on multiple information sou...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/0165-0327(88)90006-7
更新日期:1988-07-01 00:00:00
abstract:BACKGROUND:Women who have suffered from one episode of postpartum-onset major depression (PPMD) experience increased risk for recurrence in the year following another birth. METHODS:Non-depressed women (N=51) who had at least one past episode of PPMD were recruited during pregnancy. After birth, subjects were assessed...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/S0165-0327(02)00305-1
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND:Patients with bipolar disorder (BD) present widespread and significant neurocognitive impairments during all stages of the disorder. Repetitive transcranial magnetic stimulation (rTMS) has been used to improve clinical outcomes in common psychiatric diseases, such as depression, anxiety disorders, schizophre...
journal_title:Journal of affective disorders
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jad.2018.12.102
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:Poor micro-scale environmental features, such as graffiti and broken windows, have been associated with crime and signs of social disorder with a potential impact on mental health. The aim of this study is to investigate the association between micro-scale environment and mental health problems in later life...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2017.05.001
更新日期:2017-08-15 00:00:00
abstract::The DSM-III divides anxiety disorders into two broad categories, Phobic Disorders and Anxiety States. Anxiety states characterised by panic attacks have been separated from generalised anxiety disorders. While this classification may not be generally accepted it is of heuristic value. Delineation of panic disorder as ...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/0165-0327(85)90058-8
更新日期:1985-11-01 00:00:00
abstract:BACKGROUND:Pre-treatment sleep disturbance has been shown to predict antidepressant treatment outcomes. How changes in sleep disturbance during acute treatment affect longitudinal outcomes, or whether continuation-phase treatment further improves sleep disturbance, is unclear. METHODS:We assessed sleep disturbance rep...
journal_title:Journal of affective disorders
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jad.2019.10.033
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Maternal pregnancy-related anxiety (PRA) is reportedly related to neurodevelopmental outcomes of infants. However, the relationship between maternal PRA and the processing of emotions in the infant brain has not been extensively studied with neuroimaging. The objective of the present pilot study is to invest...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2019.10.047
更新日期:2020-02-01 00:00:00
abstract::Thirteen patients with major depressive disorder, 25 patients with dysthymia and 12 healthy controls underwent ergopsychometric testing. The effect of self-paced and set-paced load on mood, vigilance and perseveration tendency was recorded. Within the clinical groups, various types of load seemed to result mainly in v...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/0165-0327(91)90095-a
更新日期:1991-10-01 00:00:00
abstract:BACKGROUND:Misophonia is a psychiatric disorder in which ordinary human sounds like smacking or chewing provoke intense anger and disgust. Despite the high burden of this condition, to date there is no evidence-based treatment available. In this study we evaluated the efficacy of cognitive behavioral therapy (CBT) and ...
journal_title:Journal of affective disorders
pub_type: 临床试验,杂志文章
doi:10.1016/j.jad.2017.04.017
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:This study investigated the psychometric properties of a Chinese version of the short form of Metacognitions Questionnaire (MCQ-30), which is an effective tool to assess metacognitive beliefs that have been linked to mental disturbance/disorder. We also tested whether metacognition factors would correlate wi...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2020.08.028
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Yoga-based interventions may prove to be an attractive option for the treatment of depression. The aim of this study is to systematically review the research evidence on the effectiveness of yoga for this indication. METHODS:Searches of the major biomedical databases including MEDLINE, EMBASE, ClNAHL, PsycI...
journal_title:Journal of affective disorders
pub_type: 杂志文章,评审
doi:10.1016/j.jad.2005.08.013
更新日期:2005-12-01 00:00:00
abstract::Severe depression is characterized by anorexia and weight loss, symptoms that could endanger the patient's nutritional state. In order to investigate the nutritional state of depressed patients we determined the following in 113 healthy controls and depressed inpatients: (1) anthropometric variables such as body weigh...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/0165-0327(91)90032-n
更新日期:1991-09-01 00:00:00
abstract:BACKGROUND:Perinatal depression affects 21-50% of women in South Africa and poses significant health risks to mothers and children. Trajectories of depressive symptoms change over time and have not been well characterized during the perinatal period in low and middle-income countries. METHODS:Data from women enrolled ...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2019.08.052
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:Repetitive transcranial magnetic stimulation (rTMS) has shown efficacy in resistant unipolar depression, but its efficacy in bipolar disorders has not yet been extensively investigated. Mixed episodes are reported in up to 40% of acute bipolar admissions and are associated with severe psychopathology, comorb...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2013.12.024
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:Diagnosis and treatment rely on symptom criteria in modern psychiatry. However, the cortical mechanisms of symptomatology in major depressive disorder (MDD) are still not clear. This study examined neural correlates of symptom clusters of MDD by electroencephalography (EEG). METHODS:Resting state eye-closed...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2010.12.015
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVE:Only a minority of trauma-exposed individuals go on to develop post traumatic stress disorder (PTSD). Previous studies in high income countries suggest that maladaptive family functioning adversities (MFFA) in childhood may partially explain individual variation in vulnerability to PTSD following trauma. We t...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2018.11.056
更新日期:2019-02-15 00:00:00
abstract:BACKGROUND:Patients with major depressive disorder (MDD) can frequently develop new depressive episodes after remission. However, the neural mechanisms underlying the increased risk for depressive relapse remain unclear. Herein, we aimed to explore whether the specific changes to regional and inter-regional spontaneous...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2019.03.022
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:Many physical health problems are associated with elevated suicide risk whilst also providing access to means of overdose. We aimed to investigate whether psychiatric patients with physical co-morbidities who die by suicide were more likely than those without co-morbidities to self-poison with non-psychotrop...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2019.06.027
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Glycogen synthease kinase-3B is a key gene encoding a protein kinase which is abundant in brain, and is involved in signal transduction cascades of neuronal cell development and energy metabolism. Previous researches proposed GSK3B as a potential region for schizophrenia. METHOD:To validate the susceptibili...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2015.06.040
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Major depressive disorder (MDD) is a common psychiatric disorder that may be associated with abnormal cognitive control and emotion regulation. Previous studies have found that network disconnection within the cingulo-opercular network (CON) plays an important role in psychiatric disorders and that the CON m...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2016.04.046
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Coexisting anxiety is common in major depressive disorder (MDD) and more difficult to treat than depression without anxiety. This analysis assessed the efficacy, safety, and tolerability of vortioxetine in MDD patients with high levels of anxiety (baseline Hamilton Anxiety Rating Scale [HAM-A] total score ≥2...
journal_title:Journal of affective disorders
pub_type: 杂志文章,meta分析
doi:10.1016/j.jad.2016.07.015
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Bipolar Disorder (BD) is associated with elevated biomarkers of cell-mediated immune activation and inflammation and with signs of widespread disruption of white matter (WM) integrity in adult life. Consistent findings in animal models link WM damage in inflammatory diseases of the brain and serum levels of ...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2016.05.047
更新日期:2016-09-15 00:00:00