Abstract:
OBJECTIVE:Electroconvulsive therapy (ECT) is an effective mode of treatment--especially for severe depression and for depression refractory to pharmacotherapy, nevertheless the mode of action of ECT is far from being fully understood. This study assessed the effects of a series of ECT in depressive subjects on cerebral glucose metabolism measured by FDG-PET scans pre- and post-therapy in thus far the largest group of 12 patients. METHODS:Our analysis included careful repeated evaluation of clinical changes in mood and behaviour by standardised questionnaires, which allowed testing for a potential correlation between clinical and cerebral metabolic changes. PET scanning was done within a predefined time window and we used predefined ROIs with counts normalized to the pons activity. RESULTS:We observed few changes in cerebral glucose metabolism over time. There was a marginal increase in the left temporal and a trend for a decrease in left frontobasal areas subsequent to treatment in our sample. FDG uptake patterns remained remarkably stable in all the other predefined ROIs pre- and post-treatment. There were no significant correlations between changes in relative metabolic rates and changes in depression scores and parameters derived from neurocognitive testing. CONCLUSIONS:Our study thus cannot support the view that FDG-PET can assess the functional brain changes that are likely to occur subsequent to ECT in such a scenario, but this may be related to limited sensitivity given the sample size. Future studies thus might wish to challenge this notion in larger patient samples to clarify this issue.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Reininghaus EZ,Reininghaus B,Ille R,Fitz W,Lassnig RM,Ebner C,Annamaria P,Hofmann P,Kapfhammer HP,Reingard A,Fazekas F,Ropele S,Enzinger Cdoi
10.1016/j.jad.2012.07.034subject
Has Abstractpub_date
2013-04-05 00:00:00pages
290-4issue
2eissn
0165-0327issn
1573-2517pii
S0165-0327(12)00565-4journal_volume
146pub_type
杂志文章abstract:INTRODUCTION:Creativity is a complex construct involving affective and cognitive components. Bipolar Disorder (BD) has been associated with creativity and is characterized by a wide range of affective and cognitive symptoms. Although studies of creativity in BD have tended to focus on creativity as a trait variable in ...
journal_title:Journal of affective disorders
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journal_title:Journal of affective disorders
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doi:10.1016/j.jad.2010.09.001
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journal_title:Journal of affective disorders
pub_type: 杂志文章,评审
doi:10.1016/j.jad.2016.03.047
更新日期:2016-07-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章,meta分析,评审
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pub_type: 杂志文章,meta分析,评审
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2011.11.031
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journal_title:Journal of affective disorders
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更新日期:2005-08-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
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更新日期:2021-02-15 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
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更新日期:2009-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:1985-09-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
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更新日期:2015-03-15 00:00:00