The 3-year course and outcome of patients with major depression and silent cerebral infarction.


:We retrospectively investigated the relationship between major depression and silent cerebral infarction (SCI) over a 3-year period in 64 patients older than 50 years of age with unipolar depression. All patients underwent magnetic resonance imaging (MRI) at their first admission for depression and were classified into groups based on the presence or absence of SCI. The number of admissions due to depression was greater in the SCI (+) group (N = 32) than in the SCI (-) group (N = 32) (P < 0.05). The incidences of delirium and neurological disorders were significantly higher in the SCI (+) group than in the SCI (-) group. Our findings suggest that patients with depression and SCI had a higher rate of hospitalization and were more likely to develop psychiatric and neurological disorders than patients with depression without SCI.


J Affect Disord


Yanai I,Fujikawa T,Horiguchi J,Yamawaki S,Touhouda Y




Has Abstract


1998-01-01 00:00:00














  • Effects of glucocorticoids on the regulation of the hypothalamic-pituitary-somatotropic system in depression.

    abstract::In order to evaluate the possible effect of glucocorticoids as neuromodulators of the hypothalamic-pituitary-somatotropic system in depression, cortisol, growth hormone (GH), and insulin-like growth factor I (IGF-I) concentrations were studied before and after oral administration of 1 mg dexamethasone at 11 p.m. in 16...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Rupprecht R,Rupprecht C,Rupprecht M,Noder M,Lesch KP,Mössner J

    更新日期:1989-07-01 00:00:00

  • Enduring effects of Preventive Cognitive Therapy in adults remitted from recurrent depression: A 10 year follow-up of a randomized controlled trial.

    abstract:BACKGROUND:Prevention of recurrence is a challenge in the management of major depressive disorder (MDD). The long-term effects of Preventive Cognitive Therapy (PCT) in preventing recurrence in MDD are not known. METHODS:A RCT comparing the addition of PCT to Treatment As Usual (TAU), versus TAU including patients with...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,随机对照试验


    authors: Bockting CL,Smid NH,Koeter MW,Spinhoven P,Beck AT,Schene AH

    更新日期:2015-10-01 00:00:00

  • Psychostimulants for managing unipolar and bipolar treatment-resistant melancholic depression: a medium-term evaluation of cost benefits.

    abstract:BACKGROUND:We earlier reported an open study of 50 unipolar and bipolar treatment resistant depressed patients indicating that psychostimulants may have differential superiority for the melancholic depressive sub-type. We designed an extension study to examine cost benefits of psychostimulants more closely for those on...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Parker G,Brotchie H,McClure G,Fletcher K

    更新日期:2013-10-01 00:00:00

  • A double-blind double-dummy study of citalopram comparing infusion versus oral administration.

    abstract:BACKGROUND:This study compares antidepressant efficacy and tolerability of citalopram given either orally or as a slow drop infusion. METHODS:Citalopram (40 mg/day) was administered double-blindly as tablets or slow-drop infusion during the first 10 days and then open, orally, up to treatment Day 42. RESULTS:In 60 mo...

    journal_title:Journal of affective disorders

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Baumann P,Nil R,Bertschy G,Jecker A,Brändli H,Morand J,Kasas A,Vuagniaux O,Ramseier F

    更新日期:1998-06-01 00:00:00

  • The sales of antidepressants and suicide rates in Norway and its counties 1980-2004.

    abstract:BACKGROUND:Suicide is a major public health problem and depression is among the most important risk factors for suicide. Treatment of depression might prevent suicide. To study this hypothesis further we conducted an ecological study. METHODS:An ecological study using sales data for antidepressants and numbers of suic...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Bramness JG,Walby FA,Tverdal A

    更新日期:2007-09-01 00:00:00

  • GABA-elevating effects of the antidepressant/antipanic drug phenelzine in brain: effects of pretreatment with tranylcypromine, (-)-deprenyl and clorgyline.

    abstract::The antidepressant/antipanic drug phenelzine (PLZ) is both an inhibitor of, and a substrate for, monoamine oxidase (MAO). PLZ also causes an elevation of brain levels of the amino acid neurotransmitter gamma-aminobutyric acid (GABA); this action can be reversed by pretreatment with the MAO inhibitor tranylcypromine (T...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Todd KG,Baker GB

    更新日期:1995-12-13 00:00:00

  • Burden of dysthymia and comorbid illness in adults in a Canadian primary care setting: high rates of psychiatric illness in the offspring.

    abstract:BACKGROUND:The burden of comorbid dysthymia and other comorbid psychiatric illnesses in a Canadian primary care setting was measured. Two groups of primary care patients: those who scored positive for comorbid dysthymia versus those who scored negative for any psychiatric disorder were compared. METHODS:This was a cro...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Bell B,Chalklin L,Mills M,Browne G,Steiner M,Roberts J,Gafni A,Byrne C,Wallik D,Kraemer J,Webb M,Jamieson E,Whittaker S,Dunn E

    更新日期:2004-01-01 00:00:00

  • Childhood trauma associates with clinical features of bipolar disorder in a sample of Chinese patients.

    abstract:OBJECTIVES:Childhood trauma is a major public health problem which has a long-term consequence, a few studies have examined the relationship between childhood trauma and clinical features of bipolar disorder, most in western culture, with no such studies done in Chinese culture. METHODS:The CTQ-SF was administered to ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Li XB,Liu JT,Zhu XZ,Zhang L,Tang YL,Wang CY

    更新日期:2014-10-01 00:00:00

  • Perinatal depression and omega-3 fatty acids: a Mendelian randomisation study.

    abstract:BACKGROUND:There have been numerous studies investigating the association between omega-3 fatty acids (FAs) and depression, with mixed findings. We propose an approach which is largely free from issues such as confounding or reverse causality, to investigate this relationship using observational data from a pregnancy c...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Sallis H,Steer C,Paternoster L,Davey Smith G,Evans J

    更新日期:2014-09-01 00:00:00

  • Early effect on general interest, and short-term antidepressant efficacy and safety of agomelatine (25-50mg/day) and escitalopram (10-20mg/day) in outpatients with Major Depressive Disorder. A 12-week randomised double-blind comparative study.

    abstract:BACKGROUND:A double-blind, randomized, study was conducted in 29 centers in Romania to evaluate the effect of agomelatine 25-50mg/day (n=144 patients) on general interest, overall clinical efficacy, and functionality in comparison with escitalopram 10-20mg/day (n=143 patients) in out-patients diagnosed with moderate to...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,随机对照试验


    authors: Udristoiu T,Dehelean P,Nuss P,Raba V,Picarel-Blanchot F,de Bodinat C

    更新日期:2016-07-15 00:00:00

  • Prediction of antidepressant response in both 2.25xthreshold RUL and fixed high dose RUL ECT.

    abstract:UNLABELLED:Some forms of electroconvulsive therapy (ECT) can result in generalized seizures that lack efficacy, therefore physiological markers of treatment adequacy would be helpful. EEG measures of seizure quality, such as EEG regularity and post-ictal suppression, have largely supplanted seizure duration as a marker...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,随机对照试验


    authors: Kimball JN,Rosenquist PB,Dunn A,McCall WV

    更新日期:2009-01-01 00:00:00

  • Night shift work in resident physicians: does it affect mood states and cognitive levels?

    abstract:BACKGROUND:The effects of night shift work on health status have been widely studied. Night workers seem to smoke more, eat badly and show a low propensity to physical activity. Night work can be associated with an increase in cardiovascular and gastrointestinal disorders, alterations in immune response, diabetes, agin...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Costa C,Mondello S,Micali E,Indelicato G,Licciardello AA,Vitale E,Briguglio G,Teodoro M,Fenga C

    更新日期:2020-07-01 00:00:00

  • Effects of transcranial direct current stimulation for treating depression: A modeling study.

    abstract:BACKGROUND:Transcranial direct current stimulation (tDCS) above the left dorsolateral prefrontal cortex (lDLPFC) has been widely used to improve symptoms of major depressive disorder (MDD). However, the effects of different stimulation protocols in the entire frontal lobe have not been investigated in a large sample in...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Csifcsák G,Boayue NM,Puonti O,Thielscher A,Mittner M

    更新日期:2018-07-01 00:00:00

  • Predictors of response to ultrabrief right unilateral electroconvulsive therapy.

    abstract:BACKGROUND:Recent trials have demonstrated clinically meaningful efficacy and minimal cognitive side effects with ultrabrief pulsewidth right unilateral (RUL) ECT. In many countries it is gradually being adopted into clinical practice and further information on predictors of response is needed. METHODS:Data collected ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Loo CK,Mahon M,Katalinic N,Lyndon B,Hadzi-Pavlovic D

    更新日期:2011-04-01 00:00:00

  • Psychosocial stress and anxiety in senile dementia.

    abstract::Seventy dementia patients in hospital and two control groups comprising 50 dementia sufferers in the community and 50 mentally fit elderly people, were investigated to determine which social factors such as life events were associated with the presence of anxiety symptoms. Very high levels of social contact, problems ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Orrell M,Bebbington P

    更新日期:1996-07-29 00:00:00

  • Augmenting psychoeducation with a mobile intervention for bipolar disorder: a randomized controlled trial.

    abstract:BACKGROUND:Psychosocial interventions for bipolar disorder are frequently unavailable and resource intensive. Mobile technology may improve access to evidence-based interventions and may increase their efficacy. We evaluated the feasibility, acceptability and efficacy of an augmentative mobile ecological momentary inte...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,随机对照试验


    authors: Depp CA,Ceglowski J,Wang VC,Yaghouti F,Mausbach BT,Thompson WK,Granholm EL

    更新日期:2015-03-15 00:00:00

  • The Werther effect reconsidered in light of psychological vulnerabilities: results of a pilot study.

    abstract:BACKGROUND:Findings from three decades of epidemiological studies suggest that media diffusion of stories about suicide is related to increases in suicidal behaviours in the population exposed to the media reports. However, we still know little about the psychological processes and personal vulnerabilities that prompt ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Pouliot L,Mishara BL,Labelle R

    更新日期:2011-11-01 00:00:00

  • Effect of maternal postpartum depression on offspring's growth.

    abstract:BACKGROUND:Previous studies have linked maternal depression to different child offspring's growth outcomes. However, its effect has not been well established. The aim of this review was to evaluate the available evidence on the effect of maternal postpartum depression on offspring weight and height growth outcomes. ME...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,评审


    authors: Farías-Antúnez S,Xavier MO,Santos IS

    更新日期:2018-03-01 00:00:00

  • Imbalanced spontaneous brain activity in orbitofrontal-insular circuits in individuals with cognitive vulnerability to depression.

    abstract:BACKGROUND:The hopelessness theory of depression posits that individuals with negative cognitive styles are at risk of developing depression following negative life events. The purpose of this work was to examine whether individuals with cognitive vulnerability to depression (CVD) exhibit similar spontaneous brain acti...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Zhang X,Di X,Lei H,Yang J,Xiao J,Wang X,Yao S,Rao H

    更新日期:2016-07-01 00:00:00

  • Toward an integrative model of the spectrum of mood, behavioral and personality disorders based on fear and anger traits: I. Clinical implications.

    abstract::Current formal psychiatric approaches to nosology are plagued by an unwieldy degree of heterogeneity with insufficient appreciation of the commonalities of emotional, personality, behavioral, and addictive disorders. We address this challenge by building a spectrum model that integrates the advantages of Cloninger's a...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,评审


    authors: Lara DR,Pinto O,Akiskal K,Akiskal HS

    更新日期:2006-08-01 00:00:00

  • Heritability estimates of individual psychological distress symptoms from genetic variation.

    abstract:BACKGROUND:Psychological distress symptoms are associated with an increased risk of psychiatric disorders and medical illness. Although psychological distress is influenced by environmental factors, such as socioeconomic status, lifetime events, or interpersonal relationships, substantial interindividual variation also...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Kim S,Jang HJ,Myung W,Kim K,Cha S,Lee H,Cho SK,Kim B,Ha TH,Kim JW,Kim DK,Stahl EA,Won HH

    更新日期:2019-06-01 00:00:00

  • Intranasal oxytocin and the stress-buffering effects of social support during experimentally induced pain: The role of attachment security.

    abstract:BACKGROUND:This study examined whether intranasal oxytocin enhances the stress-buffering effects of social support during experimentally induced pain, taking into account the role of individual differences in attachment security. METHODS:Female participants (N = 193) were randomly assigned to oxytocin (24 IU intranasa...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Riem MME,Kunst LE,Kop WJ

    更新日期:2021-01-01 00:00:00

  • User, carer and staff perspectives on anxiety in dementia: a qualitative study.

    abstract:BACKGROUND:Anxiety is extremely common in dementia and can lead to social exclusion, excess disability and associated problems including high physical dependency, problems in the patient/carer relationship, and increased cognitive and behavioural difficulties. Despite this, there is little research on the detection or ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Qazi A,Spector A,Orrell M

    更新日期:2010-09-01 00:00:00

  • Altered resting-state functional connectivity in late-life depression: A cross-sectional study.

    abstract:BACKGROUND:Disrupted brain connectivity is implicated in the pathophysiology of late-life depression (LLD). There are few studies in this area using resting-state functional magnetic resonance imaging (rs-fMRI). In this pilot case-control study, we compare rs-fMRI data between age-matched depressed and non-depressed ol...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Eyre HA,Yang H,Leaver AM,Van Dyk K,Siddarth P,Cyr NS,Narr K,Ercoli L,Baune BT,Lavretsky H

    更新日期:2016-01-01 00:00:00

  • The use of the GBI in a population of adolescent offspring of parents with a bipolar disorder.

    abstract:OBJECTIVE:To assess the psychometric properties and the usefulness of the General Behavior Inventory (GBI) in the adolescent age range. METHOD:The GBI, the Schedule for Affective Disorders and Schizophrenia for School Age Children, Kiddie-SADS-Present and Lifetime Version (K-SADS-PL) and the Youth Self-Report (YSR) we...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Reichart CG,van der Ende J,Wals M,Hillegers MH,Ormel J,Nolen WA,Verhulst FC

    更新日期:2004-06-01 00:00:00

  • Introducing the concept of modern depression in Japan; an international case vignette survey.

    abstract:AIM:Japanese psychiatrists have increasingly reported patients with depression that does not seem to fit the criteria of the ICD-10 and the DSM-IV, and which has recently been called modern type depression (MTD). We explored whether MTD is frequently seen in Japan and also in other countries, and if so, how patients wi...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Kato TA,Shinfuku N,Fujisawa D,Tateno M,Ishida T,Akiyama T,Sartorius N,Teo AR,Choi TY,Wand AP,Balhara YP,Chang JP,Chang RY,Shadloo B,Ahmed HU,Lerthattasilp T,Umene-Nakano W,Horikawa H,Matsumoto R,Kuga H,Tanaka M,

    更新日期:2011-12-01 00:00:00

  • Polysomnographic features of early-onset depression: a meta-analysis.

    abstract:BACKGROUND:Undiagnosed major depressive disorder (MDD) is associated with increased morbidity in children and adolescents. This study evaluated features of sleep macro- and microarchitecture assessed by polysomnography (PSG) as diagnostic markers for MDD in children and adolescents. METHODS:MEDLINE, PSYCINFO, EMBASE a...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,meta分析,评审


    authors: Augustinavicius JL,Zanjani A,Zakzanis KK,Shapiro CM

    更新日期:2014-04-01 00:00:00

  • Diverse pathophysiological processes converge on network disruption in mania.

    abstract:BACKGROUND:Neuroimaging of psychiatric disease is challenged by the difficulty of establishing the causal role of neuroimaging abnormalities. Lesions that cause mania present a unique opportunity to understand how brain network disruption may cause mania in both lesions and in bipolar disorder. METHODS:A literature se...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Lee I,Nielsen K,Nawaz U,Hall MH,Öngür D,Keshavan M,Brady R Jr

    更新日期:2019-02-01 00:00:00

  • Validity of two case finding questions to detect postnatal depression: a review of diagnostic test accuracy.

    abstract:BACKGROUND:Postnatal depression (PND) is a serious condition associated with negative consequences for the wellbeing of mother and infant. In the UK routine screening for PND is not currently recommended, although the use of two case finding questions in routine practice to identify PND has been advocated in policy gui...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,评审


    authors: Mann R,Gilbody S

    更新日期:2011-10-01 00:00:00

  • Pharmacotherapy challenges in patients with first-episode psychosis.

    abstract::The first episode of a psychotic disorder typically occurs in late adolescence or young adulthood, a critical time of development with respect to personality, social role, education, and vocation. The first few years of psychosis appear to be a critical period during which intervention needs to be initiated before the...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,评审


    authors: Abdel-Baki A,Ouellet-Plamondon C,Malla A

    更新日期:2012-01-01 00:00:00