Abstract:
:We retrospectively investigated the relationship between major depression and silent cerebral infarction (SCI) over a 3-year period in 64 patients older than 50 years of age with unipolar depression. All patients underwent magnetic resonance imaging (MRI) at their first admission for depression and were classified into groups based on the presence or absence of SCI. The number of admissions due to depression was greater in the SCI (+) group (N = 32) than in the SCI (-) group (N = 32) (P < 0.05). The incidences of delirium and neurological disorders were significantly higher in the SCI (+) group than in the SCI (-) group. Our findings suggest that patients with depression and SCI had a higher rate of hospitalization and were more likely to develop psychiatric and neurological disorders than patients with depression without SCI.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Yanai I,Fujikawa T,Horiguchi J,Yamawaki S,Touhouda Ydoi
10.1016/s0165-0327(97)00148-1subject
Has Abstractpub_date
1998-01-01 00:00:00pages
25-30issue
1-3eissn
0165-0327issn
1573-2517pii
S0165-0327(97)00148-1journal_volume
47pub_type
杂志文章abstract:BACKGROUND:The contribution that recently identified risk factors for Postnatal Depression (PND) made to an existing prenatal screening tool ('Predictive Index' of PND; Cooper et al., 1996) was assessed in an attempt to improve the performance of this measure. METHOD:The Predictive Index and measures of appraisal and ...
journal_title:Journal of affective disorders
pub_type: 临床试验,杂志文章
doi:10.1016/s0165-0327(02)00085-x
更新日期:2003-09-01 00:00:00
abstract:BACKGROUND:Serotonin transporter (SERT) binding is decreased in lymphocytes of depression patients and this decrease is partially reversed by antidepressant medication. However, recent evidence has shown that clustering of SERT on cell membranes is very important for receptor functionality. Alteration in SERT clusterin...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2011.12.041
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:In the context of the current debate on the clinical relevance of atypical depression, the present study investigated the prevalence and specific characteristics of the disorder in depressed primary care outpatients and compared patients with atypical and with the prototypical form of depression ("non-atypic...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2004.07.003
更新日期:2004-12-01 00:00:00
abstract::Major depression (MD) and bipolar disorder (BD) are severe and potentially life-threating mood disorders whose etiology is to date not completely understood. MicroRNAs (miRNAs) are small non-coding RNAs that regulate protein synthesis post-transcriptionally by base-pairing to target gene mRNAs. Growing evidence indica...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2016.04.021
更新日期:2016-08-01 00:00:00
abstract:INTRODUCTION:Altered levels of acute-phase proteins are often described in different conditions in BD. Nevertheless, data on the association between lithium treatment and inflammatory markers in the long-term course of BD are still missing. The aim of the study was to examine the long-term course of BD concerning long-...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2020.11.063
更新日期:2021-02-15 00:00:00
abstract:BACKGROUND:Major depressive disorder (MDD) is a common disease with high morbidity and still unsatisfying treatment response. Both MDD pathogenesis and antidepressant effect are supposed to be strongly affected by genetic polymorphisms. Among promising candidate genes, distrupted in schizophrenia 1 (DISC1), translin-as...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2014.06.048
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Since its introduction in DSM-III, the validity of dysthymia has been debated. Our objective is to further examine the concept of dysthymia in an outpatient sample, and explore whether its constituents can be meaningfully apportioned. METHODS:318 patients attending the Black Dog Institute Depression Clinic ...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2012.05.051
更新日期:2012-12-20 00:00:00
abstract:BACKGROUND:Transcranial Direct Current Stimulation (tDCS) is a non-invasive, neuromodulation approach with promising efficacy for treating depression. To date, tDCS has been limited to clinical or research centre settings with treatment administered by staff. The aim of this study is to examine the efficacy, tolerabili...
journal_title:Journal of affective disorders
pub_type: 临床试验,杂志文章
doi:10.1016/j.jad.2019.04.041
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVES:The burden experienced by caregivers of patients with bipolar disorder has been associated with increased caregiver depression, anxiety and mental health service use. As caregiver burden is also associated with poor patient outcome, these findings may indicate a source of distress not only for caregivers, bu...
journal_title:Journal of affective disorders
pub_type: 杂志文章,评审
doi:10.1016/j.jad.2009.04.020
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:MiRNAs are considered to be significant contributors to the pathogenesis of psychiatric diseases, but little is known about the potential roles of miRNAs in the treatment effect of panic disorder (PD). Therefore, we aimed to identify the miRNAs association with PD over the course of sertraline treatment. ME...
journal_title:Journal of affective disorders
pub_type: 临床试验,杂志文章
doi:10.1016/j.jad.2019.03.080
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Social networking sites like Facebook represent a potentially valuable means for individuals with low self-esteem or interpersonal difficulties to connect with others; however, recent research indicates that individuals who are most in need of social benefits from Facebook may be ineffective in their communi...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2013.06.038
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:The Temperament Evaluation of Memphis Pisa Paris and San Diego Auto-questionnaire (TEMPS-A) has been translated and validated into several languages, and used in different subgroups (e.g. clinical, students, company, employees and those with different educational levels). METHODS:Lebanon is the only country...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2006.06.029
更新日期:2007-02-01 00:00:00
abstract:BACKGROUND:Our lab has previously found that structural integrity in tracts from the raphe nucleus (RN) to the amygdala, measured by fractional anisotropy (FA), predicts remission to selective serotonin reuptake inhibitors (SSRIs) in major depressive disorder (MDD). This could potentially serve as a biomarker for remis...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2019.05.055
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:Adolescent suicide ideation (SI) has received increased attention in recent years, and emotion reactivity (ER) has been found to be a risk factor for SI. However, little is known about the mediating and moderating mechanisms underlying this relationship. The aim of this study is to test a moderated mediation...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2020.01.083
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Whether there is a difference in perceived social support (PSS) and related factors among college students from one- and multiple-child families was unclear. METHODS:We conducted a population-based, cross-sectional study between October 2017 and February 2018, randomly selected college students with sibling...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2020.07.027
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:The TIA1 gene encodes a prion-related RNA-binding protein that regulates stress-dependent synaptic plasticity and fear memory in mice. It is unknown whether genetic variation in human TIA1 is associated with differences in stress- and fear-related behavior in people. METHODS:A longitudinal, population-based...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2019.09.018
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Central banks set economy-wide interest rates to meet exclusively economic objectives. There is a strong link between indebtedness and psychiatric morbidity at the individual level, with interest rates being an important factor determining ability to repay debt. However, no prior research has explored whethe...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2018.03.003
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:Early adulthood is a period of increased risk for depression and suicide. Emotional reactivity (a tendency to react to stress with increases in negative affect and maladaptive interpretations of events) is an important risk factor for these outcomes that has been under-studied. We hypothesized that elevated ...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2018.11.033
更新日期:2019-02-15 00:00:00
abstract:BACKGROUND:Deficits in emotional processing and, in particular, in emotional self-regulation represent non-specific risk factors for transdiagnostic poor outcomes. Researches have been focusing on the investigation of possible emotional processing and regulation biomarkers. The present brief review of the literature ai...
journal_title:Journal of affective disorders
pub_type: 杂志文章,评审
doi:10.1016/j.jad.2020.06.004
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Attention deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by deficits in self-controlling attention, behavior, and emotions. In recent years, noninvasive optical techniques, such as near infrared spectroscopy (NIRS), have been used to measure the neural correlates of phar...
journal_title:Journal of affective disorders
pub_type: 杂志文章,评审
doi:10.1016/j.jad.2018.10.100
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:Current resting state imaging findings support suggestions that the neural signature of depression and therefore also its therapy should be conceptualized as a network disorder rather than a dysfunction of specific brain regions. In this study, we compared neural connectivity of adolescent patients with depr...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2016.11.024
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:This study aimed to test the validity of using the Hypomania Checklist-16 [HCL-16] to measure hypomania in a British adolescent community sample. Limited research is available concerning the characterization of hypomania among community adolescent samples, particularly in the UK, despite its potential import...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2016.08.033
更新日期:2017-01-01 00:00:00
abstract::A survey of the literature on the use of antidepressants for treating patients with panic disorder and agoraphobia with panic attacks suggests that both tricyclic antidepressants and monoamine oxidase inhibitors have efficacy in blocking panic attacks. While we have witnessed dramatic progress in the pharmacological t...
journal_title:Journal of affective disorders
pub_type: 杂志文章,评审
doi:10.1016/0165-0327(87)90020-6
更新日期:1987-09-01 00:00:00
abstract:BACKGROUND:Many studies have demonstrated that major depression is related to an activation of the inflammatory response system (IRS) with an increased production of proinflammatory cytokines. It has been shown that tricyclic antidepressants and serotonin reuptake inhibitors suppress the activation of the IRS in depres...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/s0165-0327(99)00076-2
更新日期:2000-04-01 00:00:00
abstract:BACKGROUND:Research has implicated environmental risk factors, such as meteorological variables, in suicide. However, studies have not investigated air pollution, known to induce acute medical conditions and increase mortality, in suicide. This study comprehensively assesses the temporal relationship between suicide an...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2010.08.010
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:Rapid cycling (RC) bipolar disorder (BD) is associated with more disability and worse global functioning than non-rapid cycling BD (NRC) and is understudied. This study aims to investigate clinical characteristics associated to RC in a Latin-American sample and secondarily, to generate a clinical model to te...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2018.07.051
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:Variations in circadian genes can impact biological rhythms. Given the rhythm disturbances that characterize bipolar disorder (BD), genes encoding components of molecular clocks are good candidate genes for the illness. METHODS:A family based association analysis of circadian gene single nucleotide polymorp...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2015.07.014
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Suicide attempts have been associated to both Major Depression and Borderline Personality Disorder. This report hypothesized that there would be significant clinical differences between psychiatric outpatients with Major Depression, Major Depression with a history of a suicide attempt (but low Borderline tra...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/s0165-0327(98)00009-3
更新日期:1998-05-01 00:00:00
abstract:BACKGROUND:The aim was to determine the risk of Mood Disorders (MD), particularly Bipolar Disorders (BD), in Multiple Sclerosis (MS) using standardized psychiatric diagnostic tools. METHODS:Case-control study. CASES:201 consecutive-patients with MS. CONTROLS:804 sex- and age-matched subjects without MS, randomly sel...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2013.11.008
更新日期:2014-02-01 00:00:00
abstract:INTRODUCTION:A better understanding of the specific contribution of risk factors to suicidal behavior could arise from analyzing suicidal ideation (SI) in clinical samples, and comparing single versus multiple suicide attempters through contemporary methods allowing complex and dynamical analyses of multiple and simult...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2020.04.004
更新日期:2020-07-01 00:00:00