Abstract:
BACKGROUND:Current resting state imaging findings support suggestions that the neural signature of depression and therefore also its therapy should be conceptualized as a network disorder rather than a dysfunction of specific brain regions. In this study, we compared neural connectivity of adolescent patients with depression (PAT) and matched healthy controls (HC) and analysed pre-to-post changes of seed-based network connectivities in PAT after participation in a cognitive behavioral group psychotherapy (CBT). METHODS:38 adolescents (30 female; 19 patients; 13-18 years) underwent an eyes-closed resting-state scan. PAT were scanned before (pre) and after (post) five sessions of CBT. Resting-state functional connectivity was analysed in a seed-based approach for right-sided amygdala and subgenual anterior cingulate cortex (sgACC). Symptom severity was assessed using the Beck Depression Inventory Revision (BDI-II). RESULTS:Prior to group CBT, between groups amygdala and sgACC connectivity with regions of the default mode network was stronger in the patients group relative to controls. Within the PAT group, a similar pattern significantly decreased after successful CBT. Conversely, seed-based connectivity with affective regions and regions processing cognition and salient stimuli was stronger in HC relative to PAT before CBT. Within the PAT group, a similar pattern changed with CBT. Changes in connectivity correlated with the significant pre-to-post symptom improvement, and pre-treatment amygdala connectivity predicted treatment response in depressed adolescents. LIMITATIONS:Sample size and missing long-term follow-up limit the interpretability. CONCLUSIONS:Successful group psychotherapy of depression in adolescents involved connectivity changes in resting state networks to that of healthy controls.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Straub J,Metzger CD,Plener PL,Koelch MG,Groen G,Abler Bdoi
10.1016/j.jad.2016.11.024subject
Has Abstractpub_date
2017-02-01 00:00:00pages
135-139eissn
0165-0327issn
1573-2517pii
S0165-0327(16)30381-0journal_volume
209pub_type
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