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Plasma nortriptyline and clinical response in depression.

Abstract：

:Plasma levels of nortriptyline below 50 ng/ml or above 150 ng/ml have been reported to yield results inferior to intermediate levels. In the present study, patients with uncomplicated primary, nonbipolar depression were randomly assigned to 12 weeks of treatment with NT alone or with cognitive therapy. Nine of 35 patients had mean NT plasma levels less than 50 ng/ml. Five of them improved clinically to the criterion level of less than or equal to 7 on the Hamilton Rating Scale for Depression. This improvement rate was not at all different from that of patients with mean plasma levels within the presumed therapeutic window. The upper limit of 150 ng/ml was not tested. This study is presented in the hope of reviving the apparently dormant search for optimal therapeutic plasma levels of antidepressants.

journal_name

J Affect Disord

journal_title

Journal of affective disorders

authors

Murphy GE,Simons AD,Wetzel RD

doi

10.1016/0165-0327(85)90034-5

subject

Has Abstract

pub_date

1985-03-01 00:00:00

pages

123-9

issue

2

eissn

0165-0327

issn

1573-2517

pii

0165-0327(85)90034-5

journal_volume

8

pub_type

临床试验,杂志文章,随机对照试验

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