Abstract:
BACKGROUND:Depression in later life frequently persists and perpetuating factors are of immediate therapeutic relevance to clinicians. No studies of this scale have examined both clinical and neuropsychological predictors of persistent depression in a cross-national European context. METHODS:4095 community dwelling older adults (≥ 50 yr) with clinically signficant depression (EURO-D ≥ 4) from eleven European countries in the Survey of Heath, Ageing, and Retirement in Europe (SHARE) were followed for a median of 28 months. Logistic regression analyses were conducted to determine predictors of persistent depression. RESULTS:2187 (53.4%) remained depressed at follow up. Independent predictors included: female gender, baseline functional impairment, functional decline, physical symptoms, past history of depression, increased severity of depression, early age of onset (< 50 yr), life events, financial distress and country of residence. Neuropsychological variables were associated with persistent depression but not independently of other variables. LIMITATIONS:The assessment of depression was by self-report and the data source did not contain a number of potentially relevant predictors. CONCLUSION:Individuals at risk of persistent depression may be identified and targeted for intervention. Therapeutic interventions should adopt a multimodal approach to optimise current function, prevent further functional decline and treat symptoms of depression. Country of residence may be associated with further modifiable variables.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Gallagher D,Savva GM,Kenny R,Lawlor BAdoi
10.1016/j.jad.2012.10.037subject
Has Abstractpub_date
2013-05-01 00:00:00pages
192-7issue
1-3eissn
0165-0327issn
1573-2517pii
S0165-0327(12)00734-3journal_volume
147pub_type
杂志文章abstract:BACKGROUND:Although most depressed patients are treated in primary care, not all are recognized as such. This study explores the determinants of (non-)recognition of depression by general practitioners (GPs), with a focus on specific depression symptoms as possible determinants. METHODS:Recognition of depression by GP...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2012.01.006
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND:Bipolar disorder (BD) is associated with a high prevalence of suicide attempt and completion. Family history of suicidal behavior and personal history of childhood abuse are reported risk factors for suicide among BD subjects. METHODS:BD individuals with family history of suicidal behavior and personal hist...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2007.12.225
更新日期:2008-07-01 00:00:00
abstract:BACKGROUND:Dysthymic disorder (DD) is a depressive disorder characterised by persistent low and/or irritable mood and has been identified as a major risk factor for developing major depressive disorder (MDD). MDD and DD have been associated with executive function difficulties of working memory and attention. Little is...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2014.01.024
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:Emotional sensitivity involves the ability to recognize and interpret facial expressions. This is very important for interpersonal communication. Previous studies found differences in emotional sensitivity between high social anxiety (HSA) individuals and low social anxiety (LSA) individuals. However, the un...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2020.09.111
更新日期:2021-01-15 00:00:00
abstract:BACKGROUND:Self-poisoning and self-injury have widely differing incidences in hospitals and in the community, which has led to confusion about the concept of self-harm. Categorising self-harm simply by a method may be clinically misleading because many hospital-attending patients switch from one method of harm to anoth...
journal_title:Journal of affective disorders
pub_type: 杂志文章,多中心研究
doi:10.1016/j.jad.2015.03.051
更新日期:2015-07-15 00:00:00
abstract::Tricyclic antidepressants have multiple sites of pharmacological actions which are responsible for their tolerability and toxicological problems as well as their efficacy. That fact has prompted the search for antidepressants with fewer sites of action. That search resulted in the serotonin selective reuptake inhibito...
journal_title:Journal of affective disorders
pub_type: 杂志文章,评审
doi:10.1016/s0165-0327(98)00222-5
更新日期:1998-12-01 00:00:00
abstract:BACKGROUND:Although some authors have recently investigated the co-occurrence of anxiety and bipolar disorders, the topic remains insufficiently studied. Defining the prevalence and predictors of BD-OCD comorbidity has important nosological, clinical and therapeutic implications. METHODS:A systematic review and meta-a...
journal_title:Journal of affective disorders
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.jad.2015.06.005
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Given the poor prognosis of late-life depression, it is crucial to identify those at risk. Our objective was to construct and validate a prediction rule for an unfavourable course of late-life depression. METHODS:For development and internal validation of the model, we used The Netherlands Study of Depressi...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2018.04.026
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:Suicidal ideation is relatively common among people with eating disorders (EDs). The Interpersonal-Psychological Theory of Suicide holds that suicidal ideation has two proximal causes: thwarted belongingness and perceived burdensomeness. It is unknown which ED symptoms are positively associated with suicidal...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2016.02.017
更新日期:2016-05-01 00:00:00
abstract:UNLABELLED:Biased inhibitory processing, frequency and valence of automatic thoughts, and inability to use positive schemas to regulate negative mood are cognitive factors linked to depression. These processes may underlie the established link between adaptive cognitive coping strategies (acceptance and positive refram...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2013.05.014
更新日期:2013-09-25 00:00:00
abstract::The recently completed long-term maintenance trial of full-dose imipramine for recurrent unipolar disorder provided an opportunity to examine the extent to which such doses (200-300 mg daily) are associated with persistent and adverse side effects, particularly weight change. In 115 patients we monitored weight change...
journal_title:Journal of affective disorders
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0165-0327(92)90036-6
更新日期:1992-09-01 00:00:00
abstract:BACKGROUND:Recent resting-state fMRI studies on major depressive disorder (MDD) have found altered temporal correlation between low-frequency oscillations (LFOs). However, changes on the amplitudes of these LFOs remain largely unknown. METHODS:Twenty-two medication-naive, first-episode patients with MDD and 19 age-, s...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2012.10.001
更新日期:2013-04-25 00:00:00
abstract:BACKGROUND:Recognition of depression and anxiety by general practitioners (GPs) is suboptimal and there is uncertainty as to whether particular somatic health problems hinder or facilitate GP recognition. The objective of this study was to investigate the associations between somatic health problems and GP recognition ...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2013.08.030
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:There are no previous studies comparing the prevalence and risk factors for suicidal behaviour during different phases of bipolar disorder. METHODS:In the Jorvi Bipolar Study (JoBS), 1630 psychiatric in- and outpatients were screened for bipolar disorders with the Mood Disorder Questionnaire. Using SCID I a...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2006.05.033
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Central banks set economy-wide interest rates to meet exclusively economic objectives. There is a strong link between indebtedness and psychiatric morbidity at the individual level, with interest rates being an important factor determining ability to repay debt. However, no prior research has explored whethe...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2018.03.003
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:Deficits in social cognition, e.g. theory of mind (ToM) represent core characteristics involved in the etiology of psychopathological symptoms and an important predictor of social competence. In bipolar affective disorder, evidence for ToM deficits is scant, although brain imaging studies and impairments in ...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2009.08.017
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:The aim was to determine the risk of Mood Disorders (MD), particularly Bipolar Disorders (BD), in Multiple Sclerosis (MS) using standardized psychiatric diagnostic tools. METHODS:Case-control study. CASES:201 consecutive-patients with MS. CONTROLS:804 sex- and age-matched subjects without MS, randomly sel...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2013.11.008
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:In a previous preliminary report, the perception of a decrease in ambient light intensity appeared to be correlated with depression. We prospectively studied this potential link in a controlled study. METHODS:The question, "I've noticed that the lights in my surroundings seem dimmer than usual", was added t...
journal_title:Journal of affective disorders
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jad.2007.10.021
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND:Previous studies in Eastern as well as Western countries have shown a relationship between marital status and suicide mortality. However, to date, no Korean study has calculated national suicide rates by marital status for specific genders, ages, and education levels. This study investigated whether the rela...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2018.05.003
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:Psychiatric comorbidity of autism spectrum disorder (ASD) has not been well examined. METHODS:Mood disorders in 44 consecutive outpatients with high-functioning ASD were examined at a university hospital according to DSM-IV. Inclusion criteria were an IQ of 70 or higher on the Wechsler Intelligence Scale an...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2008.02.015
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND:Borderline personality disorder (BPD) and bipolar disorder (BD) are common psychiatric diagnoses. Impulsivity and affective instability are prominent features of both illnesses, complicate treatment and are associated with poor clinical outcomes. Yet, little is known about sensorimotor control in these popul...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2016.03.027
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:The Temperament Evaluation of Memphis Pisa Paris and San Diego Auto-questionnaire (TEMPS-A) has been translated and validated into several languages, and used in different subgroups (e.g. clinical, students, company, employees and those with different educational levels). METHODS:Lebanon is the only country...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2006.06.029
更新日期:2007-02-01 00:00:00
abstract:BACKGROUND:Depression and anxiety are prevalent psychiatric disorders that carry significant morbidity. Pharmacological and psychosocial interventions are used to manage these conditions, but their efficacy is limited. Recent interest into the use of psychedelic-assisted therapy using ayahuasca, psilocybin or lysergic ...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2019.07.076
更新日期:2019-11-01 00:00:00
abstract::A clinical study was conducted to examine the effects of depression on cardiac autonomic control. Cardiac autonomic control was measured in 26 nonmedicated patients (19 females) suffering from Major Depression, melancholic type, and in 26 age- and sex-matched normal controls. We measured heart rate and high frequency ...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/s0165-0327(97)00164-x
更新日期:1998-03-01 00:00:00
abstract:INTRODUCTION:Pakistan's 2005 earthquake claimed almost 87,000 lives and displaced millions. The present study sought to assess PTSD prevalence among earthquake survivors, to evaluate its determinants, and to identify protective factors that suggest future interventions in the aftermath of disasters. METHODS:In a cross...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2011.12.023
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:The transition from adolescence to adulthood is associated with stressful adaptation experiences that may increase symptoms of depression. We explored the prevalence and sex differences of depressive symptoms and suicidal ideation in freshmen Latino college students in Puerto Rico, and identified stressful l...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2012.08.010
更新日期:2013-03-05 00:00:00
abstract:BACKGROUND:The function of the hypothalamo-pituitary-adrenal axis (HPA) has been widely investigated in mood disorders based on its role in regulating stress response. Particularly, Magnetic Resonance Imaging (MRI) reports have explored pituitary gland (PG) in both bipolar disorder (BD) and major depressive disorder (M...
journal_title:Journal of affective disorders
pub_type: 杂志文章,评审
doi:10.1016/j.jad.2017.03.066
更新日期:2017-08-15 00:00:00
abstract::Rates of depression among panic disorder patients are particularly elevated in patients with comorbid social phobia. However, it is unclear whether this association is specific to social phobia, or whether any comorbid anxiety disorder increases the risk of depression. We assessed 100 panic disorder patients and found...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/0165-0327(91)90051-s
更新日期:1991-07-01 00:00:00
abstract:BACKGROUND:Current resting state imaging findings support suggestions that the neural signature of depression and therefore also its therapy should be conceptualized as a network disorder rather than a dysfunction of specific brain regions. In this study, we compared neural connectivity of adolescent patients with depr...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2016.11.024
更新日期:2017-02-01 00:00:00
abstract:INTRODUCTION:Previous studies have indicated that mode of delivery and/or season of delivery might be risk factors for postpartum depression (PD). However, only a few studies have provided support for this supposition. This study aim was to confirm the association between mode of delivery and/or season of delivery and ...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2011.02.009
更新日期:2011-07-01 00:00:00