Abstract:
BACKGROUND:Recent resting-state fMRI studies on major depressive disorder (MDD) have found altered temporal correlation between low-frequency oscillations (LFOs). However, changes on the amplitudes of these LFOs remain largely unknown. METHODS:Twenty-two medication-naive, first-episode patients with MDD and 19 age-, sex-, education-matched healthy controls were recruited. Resting-state fMRI was obtained by using an echo-planar imaging sequence and the fractional amplitude of low-frequency fluctuations (fALFF) was calculated to investigate the amplitude of LFOs in the resting state. RESULTS:Compared with control subjects, patients with MDD showed significantly decreased fALFF in right cerebellum posterior lobe, left parahippocampal gyrus and right middle frontal gyrus and increased fALFF in left superior occipital gyrus/cuneus (p<0.05, corrected for multiple comparisons). Further receiver operating characteristic curves (ROC) analyses suggested that the alterations of fALFF in these regions might be used as markers to classify patients with MDD from healthy controls. CONCLUSIONS:These findings indicated LFOs abnormalities in MDD and the fALFF analysis might be a potential approach in further exploration of this disorder.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Liu F,Guo W,Liu L,Long Z,Ma C,Xue Z,Wang Y,Li J,Hu M,Zhang J,Du H,Zeng L,Liu Z,Wooderson SC,Tan C,Zhao J,Chen Hdoi
10.1016/j.jad.2012.10.001subject
Has Abstractpub_date
2013-04-25 00:00:00pages
401-6issue
3eissn
0165-0327issn
1573-2517pii
S0165-0327(12)00658-1journal_volume
146pub_type
杂志文章abstract:BACKGROUND:Heart Rate Variability (HRV) parameters have been used to evaluate the autonomic nervous system. We hypothesized that patients with major depressive disorder (MDD) and panic disorder (PD) showed different HRV profiles compared to healthy controls. We also hypothesized that we could predict the responder grou...
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journal_title:Journal of affective disorders
pub_type: 杂志文章
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journal_title:Journal of affective disorders
pub_type: 杂志文章,评审
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journal_title:Journal of affective disorders
pub_type: 杂志文章,随机对照试验
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更新日期:2008-04-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章,meta分析,评审
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2013.12.040
更新日期:2014-03-01 00:00:00
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journal_title:Journal of affective disorders
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doi:10.1016/j.jad.2014.11.039
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2007.05.015
更新日期:2008-01-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2016.06.030
更新日期:2016-11-15 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2013.11.010
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2013.05.007
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更新日期:1991-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-03-15 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
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更新日期:2017-01-15 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
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更新日期:2008-12-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章,meta分析,评审
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