Abstract：
BACKGROUND:Although the association between depression and body composition has been widely discussed, the effects of depression on lean body mass (LBM) are unclear. The present study aimed to investigate the association of depression with LBM. METHODS:The study included 2406 participants aged 18-69 years. The sex and body mass index (BMI) stratified analysis of covariance was performed to compare total LBM and percentage LBM (%LBM) in subjects with different depression score levels. Multiple linear regression analysis was conducted to estimate the association between depression score and serum albumin level. RESULTS:An analysis of covariance stratified by sex showed that participants with moderate-to-severe depression had significantly decreased total LBM and total and regional %LBM in men, except for total LBM and percentage gynoid LBM, which was observed in women. In the BMI stratified analysis of covariance, depression was significantly associated with decreased total and regional %LBM and with increased total and regional percentage fat body mass. In people with BMI≥25kg/m(2), the associations between depression or depressive syndrome and LBM, and total and regional %LBM are stronger compared to those with BMI<25kg/m(2). Multiple linear regression analysis showed that depression score was significantly negatively associated with serum albumin level. LIMITATIONS:This is a cross-sectional study based on a general population, some information about clinical diagnosis and medication use is not available. CONCLUSIONS:Depression had a significant negative association with LBM and serum albumin level.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Li Y,Meng L,Li Y,Sato Ydoi
10.1016/j.jad.2013.12.040subject
Has Abstractpub_date
2014-03-01 00:00:00pages
1-7eissn
0165-0327issn
1573-2517pii
S0165-0327(13)00893-8journal_volume
157pub_type
杂志文章abstract：BACKGROUND:Patients with bipolar disorder (BD) and depressive episodes are usually diagnosed with major depressive disorder (MDD). It is clinically important to estimate diagnostic conversion rate from MDD to BD and identify factors characterizing MDD patients at highest risk. We investigated conversion rate from depre...
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abstract：BACKGROUND:Several studies from different epidemiological backgrounds have shown that unipolar depression is more prevalent in females than in males. This study examines gender differences in depression in a sample of 4075 probands recruited representatively from the general population in the northern German epidemiolo...
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abstract：:The peripheral-type benzodiazepine receptor (PBR) plays a major role in steroidogenesis. This receptor is sensitive to endocrine changes and stress. Antidepressants have been demonstrated to modulate adrenal and hepatic PBR in rats. To evaluate the relationship between depression and PBR, we measured platelet PBR in u...
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doi：10.1016/0165-0327(94)00098-t
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journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2011.10.002
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journal_title：Journal of affective disorders
pub_type： 杂志文章
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journal_title：Journal of affective disorders
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journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/0165-0327(88)90078-x
更新日期：1988-09-01 00:00:00
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journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2007.12.001
更新日期：2008-08-01 00:00:00
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journal_title：Journal of affective disorders
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更新日期：2018-09-01 00:00:00
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journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2010.03.020
更新日期：2010-10-01 00:00:00
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journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2020.03.046
更新日期：2020-06-01 00:00:00
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journal_title：Journal of affective disorders
pub_type： 杂志文章,评审
doi：10.1016/j.jad.2014.04.078
更新日期：2014-09-01 00:00:00
abstract：BACKGROUND:Large sample GWAS is needed to identify genetic factors associated with depression. This study used genome-wide genotypic and phenotypic data from the COPDGene study to identify genetic risk factors for depression. METHODS:Data were from 9716 COPDGene subjects with ≥10 pack-year history. Depression was defi...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2018.09.003
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journal_title：Journal of affective disorders
pub_type： 杂志文章
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journal_title：Journal of affective disorders
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doi：10.1016/s0165-0327(97)00198-5
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journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2019.07.031
更新日期：2019-10-01 00:00:00
abstract：BACKGROUND:The possibility of using biological measures to predict the trajectory of symptoms among adolescent psychiatric inpatients has important implications. This study aimed to examine emotion regulation ability (measured via self-report) and a hypothesized proxy in resting-state functional connectivity [RSFC] bet...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2017.08.064
更新日期：2018-01-01 00:00:00
abstract：INTRODUCTION:Subsyndromal depression has been associated with an increased risk of the development of major depressive disorder (MDD). Since treatment trials of adolescent MDD often result in subsyndromal depression as the outcome, the long-term course of these youth would be useful to understand. METHODS:107 adolesce...
journal_title：Journal of affective disorders
pub_type： 临床试验,杂志文章
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更新日期：2001-03-01 00:00:00
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journal_title：Journal of affective disorders
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doi：10.1016/j.jad.2014.05.060
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journal_title：Journal of affective disorders
pub_type： 杂志文章
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更新日期：2020-01-15 00:00:00
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pub_type： 杂志文章,多中心研究
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更新日期：2009-11-01 00:00:00
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pub_type： 杂志文章
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更新日期：2019-12-01 00:00:00
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journal_title：Journal of affective disorders
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1993-08-01 00:00:00
abstract：:Narrow definitions of schizophrenia increase homogeneity at the expense of leaving unclassified many patients with shizophrenic symptoms. Family history and follow-up studies indicate that many such patients ought to be classified with those having affective disorders. This study determines morbid risks for affective ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/0165-0327(79)90020-x
更新日期：1979-03-01 00:00:00
