Abstract:
BACKGROUND:We studied emotional information processing in youth with pediatric bipolar disorder (pBD) using the late positive potential (LPP), assessing automatic allocation of attentional resources to emotionally salient stimuli, and the occipital P1, assessing early sensory processing. METHODS:Participants were 20 youth with pBD and 26 healthy controls (HC). Participants passively viewed faces with a fearful, neutral or happy expressions. Group differences were tested with general linear models. P1 was included to examine modulating effects on LPP. We calculated Bayes factor (BF) values to express strength of evidence for choosing one hypothesis over another. RESULTS:A significant emotion by group interaction for LPP amplitude was associated with a larger amplitude for happy faces for pBD than HC (F[1,40] = 6.04, p = .018); this was not modulated by P1 amplitude or latency. P1 amplitude did not differ between groups, although P1 peaked earlier for HC (F[1,40] = 5.45, p = .025). BF for LPP was 2.93, suggesting moderate evidence favoring H1. BF for P1 latency of 14.58 suggests strong evidence favoring H1. LIMITATIONS:Inclusion of children and adolescents prohibited careful control for neurodevelopmental effects. CONCLUSIONS:Larger LPP amplitude for happy faces without change in P1 suggests enhanced automatic allocation of attentional resources to positive information in pBD. Delayed P1 latency in pBD suggests slower early processing of emotional information.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Simonetti A,Lijffijt M,Kahlon RS,Gandy K,Arvind RP,Amin P,Arciniegas DB,Swann AC,Soares JC,Saxena Kdoi
10.1016/j.jad.2019.04.076subject
Has Abstractpub_date
2019-06-15 00:00:00pages
240-247eissn
0165-0327issn
1573-2517pii
S0165-0327(19)30309-Xjournal_volume
253pub_type
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