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Imipramine and weight gain during the long-term treatment of recurrent depression.

Abstract：

:The recently completed long-term maintenance trial of full-dose imipramine for recurrent unipolar disorder provided an opportunity to examine the extent to which such doses (200-300 mg daily) are associated with persistent and adverse side effects, particularly weight change. In 115 patients we monitored weight change during the three-year maintenance treatment phase to the point of trial completion, recurrence or termination. No differences were noted between individuals receiving active medication (average gain of 5.8 lbs. during an average treatment period of 725 days) versus those randomized to the 'no-drug' cells (average gain of 2.8 lbs. during an average treatment period of 422 days). Numerous other factors such as body mass index, previous weight gain and gender did not play a differential role in establishing why some individuals gained weight during long-term treatment of depression regardless of specific treatment.

journal_name

J Affect Disord

journal_title

Journal of affective disorders

authors

Frank E,Kupfer DJ,Buhari A,McEachran AB,Grochocinski VJ

doi

10.1016/0165-0327(92)90036-6

subject

Has Abstract

pub_date

1992-09-01 00:00:00

pages

65-72

issue

1

eissn

0165-0327

issn

1573-2517

pii

0165-0327(92)90036-6

journal_volume

26

pub_type

临床试验,杂志文章,随机对照试验

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