Abstract：
:Tricyclic antidepressants have multiple sites of pharmacological actions which are responsible for their tolerability and toxicological problems as well as their efficacy. That fact has prompted the search for antidepressants with fewer sites of action. That search resulted in the serotonin selective reuptake inhibitors (SSRIs), with presumably only one site of action. Although the SSRIs are safer and better tolerated than the TCAs, a significant percentage of patients do not benefit from SSRIs. A group of "atypical antidepressants" including bupropion, nefazodone, and venlafaxine are known to have multiple sites of antidepressant action but do not interact at sites associated with side effects or tolerance. Thus this group of antidepressants present an important alternative to the SSRIs in the pharmacological therapy of depression. The basic pharmacological properties of bupropion, nefazodone, and venlafaxine are presented along with clinical profiles and the role of these three antidepressants in the pharmacotherapy of depression is discussed.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Horst WD,Preskorn SHdoi
10.1016/s0165-0327(98)00222-5subject
Has Abstractpub_date
1998-12-01 00:00:00pages
237-54issue
3eissn
0165-0327issn
1573-2517pii
S0165-0327(98)00222-5journal_volume
51pub_type
杂志文章,评审abstract：BACKGROUND:Greater diversity in the experience of negative and positive emotions - emodiversity - is associated with better mental health outcomes in the general population (Quoidbach et al. 2014). However, conceptual accounts of depression suggest this might differ in clinical depression. In this study, the diversity ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2020.04.060
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND:Although the association between depression and body composition has been widely discussed, the effects of depression on lean body mass (LBM) are unclear. The present study aimed to investigate the association of depression with LBM. METHODS:The study included 2406 participants aged 18-69 years. The sex and...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2013.12.040
更新日期：2014-03-01 00:00:00
abstract：BACKGROUND:Ketamine and its enantiomers have recently been highlighted as one of the most effective therapeutic options in refractory depression. However, racemic ketamine and esketamine have not been directly compared. The aim of this study is to assess the efficacy and safety of esketamine compared to ketamine in pat...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2019.11.086
更新日期：2020-03-01 00:00:00
abstract：BACKGROUND:It is essential to identify factors associated with depression as it is a highly prevalent and disabling mental disorder. The aim of this study was to examine the association between depressive symptoms and household food security status among the Canadian adult population. METHODS:This is a cross-sectional...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2020.10.057
更新日期：2021-01-15 00:00:00
abstract：BACKGROUND:fMRI graph theory reveals resting-state brain networks, but has never been used in pediatric OCD. METHODS:Whole-brain resting-state fMRI was acquired at 3T from 21 children with OCD and 20 age-matched healthy controls. BOLD connectivity was analyzed yielding global and local graph-theory metrics across 100 ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2015.12.071
更新日期：2016-03-15 00:00:00
abstract：BACKGROUND:Transcranial magnetic stimulation (TMS) of the dorsolateral prefrontal cortex is a brain stimulation technique widely used to treat depression. BDNF serum concentrations have been shown to be decreased in patients with major depressive disorder and can be upregulated by several antidepressive treatment strat...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2007.08.008
更新日期：2008-04-01 00:00:00
abstract：BACKGROUND:Little is known about gender differences in the costs and outcomes of primary care quality improvement strategies for depression. METHODS:Intent-to-treat analysis of data from a group-level controlled trial, in which matched primary care clinics in the US were randomized to usual care or to one of two inter...
journal_title：Journal of affective disorders
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jad.2005.03.018
更新日期：2005-08-01 00:00:00
abstract：:Eighty-six patients suffering from nonpsychotic unipolar major depressive disorder, according to Research Diagnostic Criteria, were rated on a modified Hamilton Rating Scale for Depression (HRS). All completed the self-rating Beck Depression Inventory (BDI). Distal colon motility (dcm) studies, performed in all the pa...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/0165-0327(83)90032-0
更新日期：1983-02-01 00:00:00
abstract：BACKGROUND:Although exposure to direct forms of childhood maltreatment is among the most widely studied risk factors for nonsuicidal self-injury (NSSI), research on NSSI has largely overlooked the role of exposure to indirect forms of child maltreatment (i.e., witnessing domestic violence). To address this gap in the l...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2016.04.041
更新日期：2016-08-01 00:00:00
abstract：BACKGROUND:Depression is a seriously disabling public health problem with very high world-wide prevalence. This study examined cross-sectional association between depression and both inflammatory markers and laboratory data involved in metabolic disturbance among Japanese subjects. METHODS:This cross-sectional study i...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2018.09.014
更新日期：2019-01-15 00:00:00
abstract：:Background. Social phobia has been under-recognised and under-treated in many countries. Little is known about its economic impact. This study aimed to identify the economic consequences of social phobia for individuals, health services and wider society. Methods. Secondary analysis of 1993-1994 Psychiatric Morbidity ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/s0165-0327(00)00323-2
更新日期：2002-04-01 00:00:00
abstract：BACKGROUND:Although genetic influences on bipolar I disorder are well established, localization of genes that predispose to the illness has been difficult. Some genes predisposing to bipolar I disorder may be transmitted without expression of the categorical clinical phenotype. One strategy to overcome this obstacle is...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2009.07.017
更新日期：2010-05-01 00:00:00
abstract：BACKGROUND:While major depressive disorder (MDD) is considered to be a heterogeneous disorder, the nature of the heterogeneity remains unclear. Studies have attempted to classify patients with MDD using latent variable techniques, yet the empirical approaches to symptom-based subtyping of MDD have not provided conclusi...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2017.03.053
更新日期：2017-08-01 00:00:00
abstract：BACKGROUND:There remains considerable disagreement regarding the relative efficacy of psychotherapy and medication across types of depression. METHOD:We used random effects meta-analysis to examine the relative efficacy of psychotherapy vis-à-vis medication at post-treatment and follow-up. We also estimated the relati...
journal_title：Journal of affective disorders
pub_type： 杂志文章,meta分析
doi：10.1016/j.jad.2008.03.018
更新日期：2008-10-01 00:00:00
abstract：BACKGROUND:Antidepressants enter the brain to reach their site of action in a different extent. However, there has been no study to date about duloxetine's ability to enter the brain and cerebrospinal fluid. Aim of this study was to measure blood and cerebrospinal fluid concentrations of duloxetine and to account for t...
journal_title：Journal of affective disorders
pub_type： 临床试验,杂志文章
doi：10.1016/j.jad.2015.08.073
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:Although brain neurochemistry is thought to play a role in the development of premenstrual dysphoric disorder (PMDD), neuroimaging studies of PMDD are sparse. We examined the extent to which gray matter (GM) abnormalities were present in women with PMDD compared to healthy controls. METHODS:3.0T magnetic re...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2012.02.010
更新日期：2012-11-01 00:00:00
abstract：:Twenty inpatients suffering from an adjustment disorder with depressed mood according to the DSM-III criteria were compared with 22 inpatients with a (situationally provoked) major depression without an additional DSM-III/axis I diagnosis, with regard to expert- and self-rated symptomatology, social dysfunction and pe...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/0165-0327(89)90004-9
更新日期：1989-11-01 00:00:00
abstract：BACKGROUND:Major depressive disorder (MDD) and bipolar disorder (BP) are two different types of mood disorders, sometimes difficult to distinguish from their depressive symptoms, and for which repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex (DLPFC) has been proposed to treat re...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2015.04.029
更新日期：2015-09-01 00:00:00
abstract：:The first episode of a psychotic disorder typically occurs in late adolescence or young adulthood, a critical time of development with respect to personality, social role, education, and vocation. The first few years of psychosis appear to be a critical period during which intervention needs to be initiated before the...
journal_title：Journal of affective disorders
pub_type： 杂志文章,评审
doi：10.1016/j.jad.2012.02.029
更新日期：2012-01-01 00:00:00
abstract：BACKGROUND:The possibility of using biological measures to predict the trajectory of symptoms among adolescent psychiatric inpatients has important implications. This study aimed to examine emotion regulation ability (measured via self-report) and a hypothesized proxy in resting-state functional connectivity [RSFC] bet...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2017.08.064
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Recognition by the DSM-IV of rapid cyclicity as a course specifier has raised the question of the stability and long-term outcome of rapid-cycling (RC) patients. Data on this topic is sparse and often inconsistent. To our knowledge, these are the first personally followed patients over the long term, dealing...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/s0165-0327(02)00321-x
更新日期：2003-01-01 00:00:00
abstract：BACKGROUND:The symptoms that contribute to the clinical diagnosis of depression likely emerge from, or are related to, underlying cognitive deficits. To understand this relationship further, we examined the relationship between self-reported somatic and cognitive-affective Beck'sDepression Inventory-II (BDI-II) symptom...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2014.09.054
更新日期：2015-02-01 00:00:00
abstract：BACKGROUND:Despite positive effects on prognosis, less than half of the people diagnosed with depression access mental health services. Knowledge of what promotes such service use is limited. There is dispute about whether the receipt of mental illness related information encourages or discourages service use among tho...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2016.08.074
更新日期：2017-01-15 00:00:00
abstract：BACKGROUND:Socioeconomic status, as measured by education, occupation or income, is associated with depression. However, data are lacking on the psychosocial, material and behavioral mediators of these associations. We have examined the association of education, occupation and income with depression and the potential m...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2018.08.077
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:Depression in pregnancy is a serious health issue; however, anxiety in pregnancy, with a reported higher prevalence, may also be a serious issue. Anxiety symptoms in pregnancy can relate to several anxiety types, such as general anxiety, anxiety disorders, and pregnancy-related anxiety (PrA), anxiety charact...
journal_title：Journal of affective disorders
pub_type： 杂志文章,评审
doi：10.1016/j.jad.2015.01.039
更新日期：2015-05-01 00:00:00
abstract：BACKGROUND:The exact neurophysiological mechanism of electroconvulsive therapy (ECT) for treating patients with depression remains elusive. Results of previous neurophysiological studies support the hypothesis that aberrant functional connectivity underlies the pathophysiology of depression, which engenders abnormal el...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2013.04.029
更新日期：2013-09-05 00:00:00
abstract：BACKGROUND:Absence due to mental disease in the workplace has become a global public health problem. We aimed to evaluate the influence of presenteeism on depression and absence due to mental disease. METHODS:A prospective study of 1831 Japanese employees from all areas of Japan was conducted. Presenteeism and depress...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2015.03.034
更新日期：2015-07-15 00:00:00
abstract：BACKGROUND:Female fetuses are more vulnerable to high levels of maternal glucocorticoids. We examined whether exposure to prenatal maternal depression, a condition associated with high glucocorticoids, carries greater risk for depression at 12 and 18 years in girls. METHODS:Our sample comprised 7959 mothers and childr...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2015.09.039
更新日期：2016-01-01 00:00:00
abstract：:Thirty-eight patients with seasonal affective disorder (SAD) were compared with 33 non-seasonal recurrent major depressives (non-SAD) who presented during the winter months for differences in the prevalence of concurrent anxiety disorders and the impact of anxiety on treatment response. SAD patients received light the...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/0165-0327(93)90076-v
更新日期：1993-05-01 00:00:00
abstract：BACKGROUND:Late-life depression is associated with premature mortality, however, little is known whether excess mortality rates of depression have changed over time. This study aims to identify and explain secular trends in excess mortality of major depressive disorder (MDD) and subthreshold depression (SUBD). METHODS...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2018.02.068
更新日期：2018-07-01 00:00:00
