Abstract:
BACKGROUND:Although brain neurochemistry is thought to play a role in the development of premenstrual dysphoric disorder (PMDD), neuroimaging studies of PMDD are sparse. We examined the extent to which gray matter (GM) abnormalities were present in women with PMDD compared to healthy controls. METHODS:3.0T magnetic resonance imaging scans of 15 women with PMDD and 15 healthy controls were compared using optimized voxel-based morphometry (VBM) analysis. A regression analysis was used to assess the relationship between GM density and PMDD-symptom severity. RESULTS:Our results showed significantly increased GM density in the hippocampal cortex and significantly decreased GM density in the parahippocampal cortex among women with PMDD compared to healthy controls. However, these GM abnormalities were not significantly associated with the severity of PMDD. LIMITATION:Our inferences of the relationships between structural alterations and PMDD are drawn from a small sample, which may have increased the likelihood of type I error. CONCLUSIONS:GM abnormalities in limbic and paralimbic cortices were found to be associated with the pathophysiology of PMDD. Etiology of PMDD is likely related to emotional processing and self-regulation. Our findings provide a basis of neurobiological model for PMDD.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Jeong HG,Ham BJ,Yeo HB,Jung IK,Joe SHdoi
10.1016/j.jad.2012.02.010subject
Has Abstractpub_date
2012-11-01 00:00:00pages
260-7issue
3eissn
0165-0327issn
1573-2517pii
S0165-0327(12)00106-1journal_volume
140pub_type
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journal_title:Journal of affective disorders
pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
doi:10.1016/j.jad.2012.07.028
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journal_title:Journal of affective disorders
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1990-04-01 00:00:00
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更新日期:2019-05-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
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更新日期:2012-02-01 00:00:00
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更新日期:2012-06-01 00:00:00