Abstract：
BACKGROUND:Hypothalamic-pituitary-adrenal (HPA) axis dysregulation has been reported in bipolar disorder (BD), but previous magnetic resonance imaging (MRI) studies of pituitary gland volume in BD have yielded inconsistent findings. In addition, the contribution of genetic factors to the pituitary changes in BD remains largely unknown. METHOD:We used MRI to investigate the pituitary volume in 29 remitted patients with BD, 49 of their first-degree relatives (of whom 15 had a diagnosis of Major Depressive Disorder), and 52 age- and gender-matched healthy controls. RESULTS:BD patients had a significantly larger pituitary volume compared with their relatives and healthy controls. Pituitary volume did not differ between controls and healthy relatives or relatives diagnosed with major depression. LIMITATIONS:Direct measures of HPA function (i.e., hormonal levels) were not available. CONCLUSIONS:These findings suggest that enlarged pituitary volume is associated with disease expression but not genetic susceptibility to BD.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Takahashi T,Walterfang M,Wood SJ,Kempton MJ,Jogia J,Lorenzetti V,Soulsby B,Suzuki M,Velakoulis D,Pantelis C,Frangou Sdoi
10.1016/j.jad.2009.12.002subject
Has Abstractpub_date
2010-08-01 00:00:00pages
256-61issue
3eissn
0165-0327issn
1573-2517pii
S0165-0327(09)00534-5journal_volume
124pub_type
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