Abstract:
BACKGROUND:Lithium is still regarded as a cornerstone for the long-term treatment of bipolar disorder. The best response to lithium is associated with clinical features of episodic clinical course, complete remission, bipolar family history and low psychiatric comorbidity. However, a specific personality profile for the best lithium response was not estimated so far. Such a possibility occurred with an advent of temperament scale for bipolar disorder and of an ability to quantitatively assess lithium prophylactic response. METHODS:The study was performed on 71 patients with bipolar mood disorder (21 males, 50 females), aged 31-82 (59±12) years, which have been treated with lithium carbonate for at least 5 years (5-37 years, mean 15 years). In all patients, the assessment of five temperaments of TEMPS-A scale (depressive, cyclothymic, hyperthymic, irritable and anxious) was done, and correlated with the quality of lithium prophylaxis according to Alda scale. RESULTS:The mean scores for five temperaments of TEMPS-A were not significantly different in male and female patients. The response to lithium correlated significantly positively with hyperthymic temperament score (r=0.31, p=0.009), and negatively with anxiety (r=-0.27, p=0.022), cyclothymic (r=-0.26, p=0.032), and depressive (r=-0.23, p=0.052) temperaments scores. LIMITATIONS:Relatively small number of patients. CONCLUSIONS:The main finding of the study is an association of lithium response with hyperthymic temperament. This positive correlation as well as other negative correlations between lithium response and TEMPS-A temperaments are discussed in view of clinical and genetic findings in bipolar patients.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Rybakowski JK,Dembinska D,Kliwicki S,Akiskal KK,Akiskal HHdoi
10.1016/j.jad.2012.07.028subject
Has Abstractpub_date
2013-02-20 00:00:00pages
187-9issue
2eissn
0165-0327issn
1573-2517pii
S0165-0327(12)00559-9journal_volume
145pub_type
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