Abstract：
OBJECTIVES:Neurophysiologic correlates of depression severity potentially have great utility in diagnosis and treatment planning. Transcranial magnetic stimulation (TMS) measures of cortical inhibition and excitability have shown promise as biomarkers in psychiatry, but no prior work has examined correlates of illness severity in pediatric mood disorders. This study sought to examine the relationship between depression severity and TMS measures of cortical inhibition and excitability in children and adolescents. METHODS:Twenty-four depressed and 22 healthy control youth underwent TMS testing (cortical silent period [CSP], short-interval intracortical inhibition at 2-ms and 4-ms interstimulus intervals (ISIs) [SICI-2,-4], resting motor threshold [RMT] and intracortical facilitation at 10-, 15-, and 20-ms ISIs [ICF-10,-15,-20]). Symptom severity was assessed with the Quick Inventory of Depressive Symptomatology (QIDS-A17-SR) and the Children's Depression Rating Scale-Revised (CDRS-R). RESULTS:In the overall sample, the following significant negative correlations were observed: CDRS-R and CSP (right hemisphere, ρ=-0.35, p=0.021); QIDS-A17-SR and CSP (left, ρ=-0.33, p=0.031; right, ρ=-0.42, p=0.004); and CDRS-R and SICI-4 (right, ρ=-0.30, p=0.042). Among healthy control participants, additional significant negative correlations were observed between QIDS-A17-SR and right ICF-10; QIDS-A17-SR and right ICF-15; and QIDS-A17-SR and left ICF-20. Among depressed participants, significant negative correlations were observed between QIDS-A17-SR and bilateral CSP; CDRS-R and bilateral ICF-10; CDRS-R and bilateral ICF-15; QIDS-A17-SR and left ICF-10; and QIDS-A17-SR and bilateral ICF-15. LIMITATIONS:Small sample, potential developmental/age- and sex-related effects. CONCLUSIONS:These preliminary results provide evidence for a relationship between depression severity and dysfunction in GABAergic and glutamatergic cortical processes in a pediatric population.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Lewis CP,Nakonezny PA,Ameis SH,Vande Voort JL,Husain MM,Emslie GJ,Daskalakis ZJ,Croarkin PEdoi
10.1016/j.jad.2015.10.020subject
Has Abstractpub_date
2016-01-15 00:00:00pages
566-575eissn
0165-0327issn
1573-2517pii
S0165-0327(15)30816-8journal_volume
190pub_type
杂志文章abstract：BACKGROUND:The DSM-IV diagnosis of acute stress disorder (ASD) describes a posttraumatic reaction that occurs two to twenty-eight days following a trauma and involves symptoms of intrusion, avoidance, hyper-arousal and dissociation. A better understanding of ASD and its pathogenesis could lead to improved post-trauma h...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2013.01.041
更新日期：2013-07-01 00:00:00
abstract：BACKGROUND:Suicidality among youth with bipolar disorder is an extreme, but largely unaddressed, public health problem. The current study examined the psychosocial characteristics differentiating youth with varying severities of suicidal ideation that may dictate targets for suicide prevention interventions. METHODS:P...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2014.10.058
更新日期：2015-03-01 00:00:00
abstract：BACKGROUND:Misophonia is a psychiatric disorder in which ordinary human sounds like smacking or chewing provoke intense anger and disgust. Despite the high burden of this condition, to date there is no evidence-based treatment available. In this study we evaluated the efficacy of cognitive behavioral therapy (CBT) and ...
journal_title：Journal of affective disorders
pub_type： 临床试验,杂志文章
doi：10.1016/j.jad.2017.04.017
更新日期：2017-08-01 00:00:00
abstract：BACKGROUND:Valproic acid (VPA) is widely used for treating patients with bipolar disorder; however, it has adverse effects on cognitive function. This study investigated the effect of VPA on the risk of dementia in patients with bipolar disorder. METHODS:We analyzed data from Taiwan's Longitudinal Health Insurance Dat...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2016.05.010
更新日期：2016-09-01 00:00:00
abstract：:This paper reports the 1-year follow-up of a sample of depressed patients. Social cognitive variables obtained during the index episode, including ideal emotional support, roles and goals investment in various domains and dysfunctional attitudes were used to predict subjects' likelihood for subsequent relapse. More su...
journal_title：Journal of affective disorders
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0165-0327(95)00075-5
更新日期：1996-04-12 00:00:00
abstract：BACKGROUND:An elevated risk of late-life depression has been suggested in older adults from minority ethnic groups, but little is known about ethnic group differences in symptom and treatment profiles. The current study aimed to compare symptoms and types of treatment between ethnic groups in patients with late-life de...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2019.12.031
更新日期：2020-03-01 00:00:00
abstract：OBJECTIVE:To evaluate the efficacy of gabapentin as an adjunctive treatment for bipolar disorder in both depressed and manic phases. METHOD:Thirty seven patients with bipolar type I or II with or without a rapid cycling course were openly treated with gabapentin added to current treatment for up to six months. Mood sy...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/s0165-0327(98)00192-x
更新日期：1999-09-01 00:00:00
abstract：BACKGROUND:The loss of an expected child is a psychologically difficult and potentially traumatic life event. While most women will become pregnant again within a year following the loss, data are limited regarding the mental health of parents with a history of perinatal loss, especially in the period following the bir...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2020.11.016
更新日期：2021-02-01 00:00:00
abstract：INTRODUCTION:Social phobia is among the most frequent psychiatric disorders and can be classified into two subtypes, nongeneralized and generalized. Whereas it significantly worsens the morbidity of comorbid substance abuse disorders, and it often is associated with reduced treatment responses, there is still lacking d...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2004.05.003
更新日期：2004-11-15 00:00:00
abstract：OBJECTIVE:The 5-HTTLPR polymorphism has been associated both with depression and aggression/hostility. The multidirectional association between depression, aggression and the s allele may be important, since all these phenomena are related to suicidal behavior. Our aim was to investigate the association between 5-HTTLP...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2011.03.029
更新日期：2011-08-01 00:00:00
abstract：BACKGROUND:This study aims to examine associations between serum 25-hydroxyvitamin D [25(OH)D] concentrations and depressive symptoms in an older Korean population. METHODS:The study used data from the Korean Urban Rural Elderly study, which enrolled 2942 participants aged 65 years or older from urban and rural commun...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2015.09.043
更新日期：2016-01-01 00:00:00
abstract：:To investigate the effect of dexamethasone dosage upon the outcome of the dexamethasone suppression test (DST) and the role of concurrent plasma dexamethasone concentrations, four different dexamethasone dosages were administered to 119 hospitalized depressed patients (0.5 mg: n = 12; 1.0 mg: n = 30; 1.5 mg: n = 42; 2...
journal_title：Journal of affective disorders
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0165-0327(90)90018-4
更新日期：1990-06-01 00:00:00
abstract：BACKGROUND:Interpretation bias, which involves interpreting ambiguous social events negatively and catastrophising even mildly negative social events, has been suggested as a key maintenance factor of Social Anxiety Disorder. Although some individual studies and narrative reviews have demonstrated a role for negative i...
journal_title：Journal of affective disorders
pub_type： 杂志文章,评审
doi：10.1016/j.jad.2020.07.121
更新日期：2020-11-01 00:00:00
abstract：BACKGROUND:Bipolar disorder (BD) is associated with a high prevalence of suicide attempt and completion. Family history of suicidal behavior and personal history of childhood abuse are reported risk factors for suicide among BD subjects. METHODS:BD individuals with family history of suicidal behavior and personal hist...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2007.12.225
更新日期：2008-07-01 00:00:00
abstract：BACKGROUND:Although recent neuroimaging studies have suggested that functional deficits in facial perception are associated with panic disorder (PD), the possibility of cortical thickness and perfusion abnormalities have not been studied in patients with PD. We aimed to investigate alterations in cortical thickness and...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2020.07.139
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:The personality trait of Persistence is highly valued by conscientious overachievers, but it has both psychological costs and benefits. The interactions among multiple personality factors influencing the development of mood and anxiety disorders have been confounded in prior clinical samples, but can be dise...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2011.09.046
更新日期：2012-02-01 00:00:00
abstract：BACKGROUND:Depression has been associated with adverse clinical events in myocardial infarction (MI) patients, but many questions about the nature of post-MI depression remain unanswered. We examined whether depressive cognitions characteristic of depression in psychiatric patients are also present in post-MI patients ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2006.04.023
更新日期：2006-08-01 00:00:00
abstract：BACKGROUND:To examine neuroticism as a possible determinant of depression in alcoholics. METHOD:24 euthymic depressed alcoholics and 18 never-depressed alcoholic controls completed the Eysenck Personality Questionnaire. RESULT:Euthymic depressed alcoholics had significantly higher neuroticism scores than alcoholic co...
journal_title：Journal of affective disorders
pub_type： 临床试验,杂志文章
doi：10.1016/s0165-0327(98)00071-8
更新日期：1999-01-01 00:00:00
abstract：BACKGROUND:Previously published data show large differences between euthymic Israeli adult bipolar patients and US normative data on several measures of psychological functioning as assessed with a sensitive projective measure (Rorschach Inkblot Test). The current study examines the Rorschach performance of healthy off...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/s0165-0327(99)00148-2
更新日期：2000-09-01 00:00:00
abstract：:Endogenously depressed in-patients were treated for four weeks with either lithium + L-tryptophan (N = 22) or amitriptyline (N = 21) in an open study. Before and weekly during treatment the patients were evaluated by means of Hamilton rating scale, and blood samples were collected for determination of serum concentrat...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/0165-0327(82)90022-2
更新日期：1982-03-01 00:00:00
abstract：BACKGROUND:Chronic exercise has been shown to have therapeutic effects in panic disorder (PD). The mechanism of these effects is unknown. Acute exercise reduces the effect of a panic challenge in healthy volunteers. Such an effect has not yet been demonstrated in PD patients. The present study aimed at exploring the an...
journal_title：Journal of affective disorders
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jad.2007.07.022
更新日期：2008-04-01 00:00:00
abstract：BACKGROUND:Depression is the single largest contributor to non-fatal health loss worldwide. A role of inflammation in major depressive disorder (MDD) was suggested, and we sought to determine if cytokine levels predict the severity of depressive symptomatology or distinguish MDD patients from healthy controls (HCs). M...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2019.02.042
更新日期：2019-04-15 00:00:00
abstract：BACKGROUND:Patients with bipolar disorder (BD) present widespread and significant neurocognitive impairments during all stages of the disorder. Repetitive transcranial magnetic stimulation (rTMS) has been used to improve clinical outcomes in common psychiatric diseases, such as depression, anxiety disorders, schizophre...
journal_title：Journal of affective disorders
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jad.2018.12.102
更新日期：2019-03-01 00:00:00
abstract：:In a recent work by Liu et al. (2017) appeared in this journal, malondialdehyde levels proposed as a novel biomarker. Despite of wide usage of malondialdehyde as a biomarker, there are some points from analytical viewpoint which should be considered in future works. This work aimed to discuss the points briefly. ...
journal_title：Journal of affective disorders
pub_type： 评论,信件
doi：10.1016/j.jad.2017.07.050
更新日期：2018-01-01 00:00:00
abstract：:There are indications of abnormalities in membrane transport processes of erythrocytes in affective disorders. Therefore, it seemed worth while to investigate possible charge heterogeneities of erythrocyte membrane proteins in psychiatric disorders applying isoelectric focusing (IEF) in one- and two-dimensional proced...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/0165-0327(88)90089-4
更新日期：1988-09-01 00:00:00
abstract：BACKGROUND:Most of the data on lifetime psychiatric comorbidity in combat-related posttraumatic stress disorder (CR-PTSD) were collected in help-seeking patients. METHODS:In the present study we used the Schedule for Affective Disorder and Schizophrenia-Lifetime Version to examine a relatively large sample (n=80) of I...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/s0165-0327(99)00090-7
更新日期：2000-01-01 00:00:00
abstract：BACKGROUND:Epidemiological studies have consistently linked smoking to poor mental health. Among non-smokers, some studies have also reported associations between secondhand smoke exposure and psychological symptoms. However, an association between secondhand smoke exposure and depressive disorders has not been well es...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2017.08.006
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Research in paternal prenatal and postpartum depression has nearly doubled since prevalence rates were last meta-estimated in October 2009. An updated meta-analysis allows additional questions to be answered about moderators that influence risk. METHODS:Studies reporting paternal depression between the firs...
journal_title：Journal of affective disorders
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.jad.2016.07.044
更新日期：2016-12-01 00:00:00
abstract：BACKGROUND:Anxiety is extremely common in dementia and can lead to social exclusion, excess disability and associated problems including high physical dependency, problems in the patient/carer relationship, and increased cognitive and behavioural difficulties. Despite this, there is little research on the detection or ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2009.12.015
更新日期：2010-09-01 00:00:00
abstract：BACKGROUND:Depression is a major global public health concern. The aetiology of depression is partly unclear; however, intake of nutrients, such as magnesium, have been suggested to affect depressive symptoms and modify depression risk. METHODS:This research is a part of the Kuopio Ischemic Heart Disease Risk Factor (...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2015.12.056
更新日期：2016-03-15 00:00:00
