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Interaction of 5-HTTLPR genotype and unipolar major depression in the emergence of aggressive/hostile traits.

Abstract：

OBJECTIVE:The 5-HTTLPR polymorphism has been associated both with depression and aggression/hostility. The multidirectional association between depression, aggression and the s allele may be important, since all these phenomena are related to suicidal behavior. Our aim was to investigate the association between 5-HTTLPR and aggressive/hostile traits in depressed patients and controls. METHODS:137 depressive and 118 control women completed the Buss-Durkee Hostility Inventory and were genotyped for 5-HTTLPR. BDHI scores in the different groups were investigated by Generalized Linear Model Analysis. Association between dependent and independent variables in the model was tested by the likelihood ratio Chi-square statistic. RESULTS:Diagnosis and genotype showed a significant association with several aggressive/hostile traits. Interaction of the two main effects was also significant in case of several subscales. Post hoc analyses indicated a significant association between BDHI subscales and s allele only in the depressed group. LIMITATION:Only women were studied and since gender differences are present both in aggressive behavior and putatively in the behavioral effects of 5-HTTLPR genotype, our findings pertain only to females. CONCLUSION:Our results indicate a robust relationship between aggression/hostility and 5-HTTLPR genotype, but this association is more marked in the presence of depression. The presence of the s allele thus not only contributes to a higher risk of depression, but in depressives also leads to higher aggression/hostility. Our results have important implications for suicide research, since the s allele is associated with violent suicide, and this association may be mediated through the emergence of increased aggression/hostility in depressed patients carrying the s allele.

journal_name

J Affect Disord

journal_title

Journal of affective disorders

authors

Gonda X,Fountoulakis KN,Csukly G,Bagdy G,Pap D,Molnár E,Laszik A,Lazary J,Sarosi A,Faludi G,Sasvari-Szekely M,Szekely A,Rihmer Z

doi

10.1016/j.jad.2011.03.029

subject

Has Abstract

pub_date

2011-08-01 00:00:00

pages

432-7

issue

eissn

0165-0327

issn

1573-2517

pii

S0165-0327(11)00112-1

journal_volume

132

pub_type

杂志文章

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Interaction of 5-HTTLPR genotype and unipolar major depression in the emergence of aggressive/hostile traits.