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The effect of dexamethasone dosage upon plasma cortisol and dexamethasone during the DST.

Abstract：

:To investigate the effect of dexamethasone dosage upon the outcome of the dexamethasone suppression test (DST) and the role of concurrent plasma dexamethasone concentrations, four different dexamethasone dosages were administered to 119 hospitalized depressed patients (0.5 mg: n = 12; 1.0 mg: n = 30; 1.5 mg: n = 42; 2.0 mg: n = 35). Independent of the dosage, dexamethasone plasma concentrations at 4.00 p.m. were lower in DST non-suppressors than in suppressors, although differences were statistically significant only for the 1.5-mg and 2.0-mg dosages. Our findings confirm recent reports that the actual plasma concentration of dexamethasone at 4.00 p.m. does not determine DST outcome.

journal_name

J Affect Disord

journal_title

Journal of affective disorders

authors

Wiedemann K,Holsboer F

doi

10.1016/0165-0327(90)90018-4

subject

Has Abstract

pub_date

1990-06-01 00:00:00

pages

133-7

issue

2

eissn

0165-0327

issn

1573-2517

pii

0165-0327(90)90018-4

journal_volume

19

pub_type

临床试验,杂志文章,随机对照试验

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