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Gabapentin as an adjunctive treatment in bipolar disorder.

Abstract：

OBJECTIVE:To evaluate the efficacy of gabapentin as an adjunctive treatment for bipolar disorder in both depressed and manic phases. METHOD:Thirty seven patients with bipolar type I or II with or without a rapid cycling course were openly treated with gabapentin added to current treatment for up to six months. Mood symptoms were rated weekly for 12 weeks then monthly for 3 months utilizing the HamD and YMS. RESULTS:Participants experienced a significant reduction in both depressive and manic symptoms. CONCLUSIONS:These findings are consistent with others in establishing the efficacy of gabapentin in both phases of bipolar disorder. LIMITATIONS:Small sample size and the use of an open uncontrolled design limit interpretation of results.

journal_name

J Affect Disord

journal_title

Journal of affective disorders

authors

Young LT,Robb JC,Hasey GM,MacQueen GM,Patelis Siotis I,Marriott M,Joffe RT

doi

10.1016/s0165-0327(98)00192-x

subject

Has Abstract

pub_date

1999-09-01 00:00:00

pages

73-7

issue

1

eissn

0165-0327

issn

1573-2517

pii

S016503279800192X

journal_volume

55

pub_type

杂志文章

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