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Lithium + L-tryptophan compared with amitriptyline in endogenous depression.

Abstract：

:Endogenously depressed in-patients were treated for four weeks with either lithium + L-tryptophan (N = 22) or amitriptyline (N = 21) in an open study. Before and weekly during treatment the patients were evaluated by means of Hamilton rating scale, and blood samples were collected for determination of serum concentration of lithium, or amitriptyline and nortriptyline. Both groups responded significantly and the two treatments were not significantly different in antidepressive efficacy. No significant correlation could be demonstrated between clinical improvement and steady-state serum drug levels. From this study it appears that lithium combined with L-tryptophan may be effective in the treatment of endogenous depression.

journal_name

J Affect Disord

journal_title

Journal of affective disorders

authors

Honoré P,Møller SE,Jørgensen A

doi

10.1016/0165-0327(82)90022-2

subject

Has Abstract

pub_date

1982-03-01 00:00:00

pages

79-82

issue

1

eissn

0165-0327

issn

1573-2517

pii

0165-0327(82)90022-2

journal_volume

4

pub_type

杂志文章

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