当前位置： SCI文献检索 > JOURNAL OF AFFECTIVE DISORDERS期刊下所有文献 > Relevance of tryptophan and tyrosine availability in endogenous and 'non-endogenous' depressives treated with imipramine or clomipramine.

Relevance of tryptophan and tyrosine availability in endogenous and 'non-endogenous' depressives treated with imipramine or clomipramine.

Abstract：

:This study was performed on 65 depressed in-patients who were included in previously reported trials of imipramine and clomipramine. Before and during treatment, blood samples were collected for estimation of the availability of tryptophan and tyrosine by measurement of their plasma ratios to competing amino acids, and for determination of plasma steady-state concentrations of imipramine, clomipramine and their demethylated metabolites. The patients were classified as endogenous or 'non-endogenous' depressives by means of diagnostic rating scales, and therapeutic efficacy was evaluated by means of the Hamilton rating scales. Neither imipramine nor clomipramine increased the availability of tryptophan or tyrosine. Three biochemical regions were defined: a low region including mostly patients with subnormal availability of both tryptophan and tyrosine, a medium region, and a high region including mostly patients with supernormal precursor availabilities. Endogenous depressives showed about the same biochemical distribution as controls whereas there tended to be a proportionately higher number of 'non-endogenous' depressives within the low region. Patients in the low region, irrespective of diagnostic classification, improved faster and more on imipramine than patients in the medium and high regions with comparable plasma drug levels. Patients on clomipramine tended to show a relationship between precursor availabilities and clinical response but no definite conclusion could be drawn from these data. The results suggest that determination of the pre-treatment tryptophan and tyrosine availability may be superior to diagnostic classification in predicting response to imipramine. The possible mode of action of tricyclic antidepressants is briefly discussed.

journal_name

J Affect Disord

journal_title

Journal of affective disorders

authors

Møller SE,Reisby N,Ortmann J,Elley J,Krautwald O

doi

10.1016/0165-0327(81)90025-2

subject

Has Abstract

pub_date

1981-09-01 00:00:00

pages

231-44

issue

3

eissn

0165-0327

issn

1573-2517

pii

0165-0327(81)90025-2

journal_volume

3

pub_type

杂志文章

相关文献

JOURNAL OF AFFECTIVE DISORDERS文献大全
  • Risk factors for suicide in bipolar disorder: a systematic review.

    abstract：BACKGROUND:Bipolar disorder confers the highest risk of suicide among major psychological disorders. The risk factors associated with bipolar disorder and suicide exist and are relevant to clinicians and researchers. OBJECTIVE:The aim of the present study was to conduct a systematic review of articles regarding the su...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.jad.2014.09.003

    authors： Costa Lda S,Alencar ÁP,Nascimento Neto PJ,dos Santos Mdo S,da Silva CG,Pinheiro Sde F,Silveira RT,Bianco BA,Pinheiro RF Jr,de Lima MA,Reis AO,Rolim Neto ML

    更新日期：2015-01-01 00:00:00

  • Fluoxetine versus sertraline and paroxetine in major depression: tolerability and efficacy in anxious depression.

    abstract：BACKGROUND:Major depression with high levels of anxiety (anxious depression) is a common subtype of depression associated with greater psychosocial impairment and poorer response to antidepressant treatment. It is unclear whether in this population there are differences in efficacy or tolerability across selective sero...

    journal_title：Journal of affective disorders

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0165-0327(99)00131-7

    authors： Fava M,Rosenbaum JF,Hoog SL,Tepner RG,Kopp JB,Nilsson ME

    更新日期：2000-08-01 00:00:00

  • Does sleep disturbance mediate neuropsychological functioning in older people with depression?

    abstract：BACKGROUND:Depression in older adults is associated with neuropsychological dysfunction, fronto-subcortical brain changes and sleep disturbance. Research suggests that adequate sleep is critical for many aspects of cognition including processing speed, verbal skills and memory. However, the association between sleep di...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2008.11.017

    authors： Naismith SL,Norrie L,Lewis SJ,Rogers NL,Scott EM,Hickie IB

    更新日期：2009-07-01 00:00:00

  • Psychosocial factors associated with symptoms of depression, anxiety and stress among single mothers with young children: A population-based study.

    abstract：BACKGROUND:Abundant evidence highlights single parenthood as a common risk factor for depression, anxiety and stress but few studies have comprehensively examined psychosocial factors (adversities), particularly during early parenting. We investigated symptom prevalence and potential risk factors among mothers with ver...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2018.08.013

    authors： Liang LA,Berger U,Brand C

    更新日期：2019-01-01 00:00:00

  • Racial/ethnic differences in the treatment of adolescent major depressive disorders (MDD) across healthcare providers participating in the medicaid program.

    abstract：BACKGROUND:To examine whether racial/ethnic differences in receipt of MDD treatment could be explained by the specialty of provider diagnosing the adolescent. METHOD:Adolescents (10-20 years-old) with ≥2 MDD diagnoses were identified using 2005-2007 Medicaid data from Texas. Patients were categorized based on the type...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2018.04.045

    authors： Yucel A,Essien EJ,Sanyal S,Mgbere O,Aparasu RR,Bhatara VS,Alonzo JP,Chen H

    更新日期：2018-08-01 00:00:00

  • Chronotype and seasonality: morningness is associated with lower seasonal mood and behavior changes in the Old Order Amish.

    abstract：BACKGROUND:Several studies documented that lower scores on the Morningness-Eveningness Questionnaire (MEQ) are associated with a higher global seasonality of mood (GSS). As for the Modern Man artificial lighting predominantly extends evening activity and exposure to light, and as evening bright light phase is known to ...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2014.11.039

    authors： Zhang L,Evans DS,Raheja UK,Stephens SH,Stiller JW,Reeves GM,Johnson M,Ryan KA,Weizel N,Vaswani D,McLain H,Shuldiner AR,Mitchell BD,Hsueh WC,Snitker S,Postolache TT

    更新日期：2015-03-15 00:00:00

  • Psychiatric disorders and functional impairment among disaster victims after exposure to a natural disaster: a population based study.

    abstract：OBJECTIVE:We aimed to examine psychiatric morbidity and functional impairment after a natural disaster. METHOD:Norwegian tourists who survived the 2004 tsunami in Khao Lak (n = 63), a severely affected area in Thailand, were interviewed in person 2.5 years after the disaster. The examination included the Mini Internat...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2010.06.018

    authors： Hussain A,Weisaeth L,Heir T

    更新日期：2011-01-01 00:00:00

  • TEMPS-A and long-term lithium response: positive correlation with hyperthymic temperament.

    abstract：BACKGROUND:Lithium is still regarded as a cornerstone for the long-term treatment of bipolar disorder. The best response to lithium is associated with clinical features of episodic clinical course, complete remission, bipolar family history and low psychiatric comorbidity. However, a specific personality profile for th...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2012.07.028

    authors： Rybakowski JK,Dembinska D,Kliwicki S,Akiskal KK,Akiskal HH

    更新日期：2013-02-20 00:00:00

  • Resting electroencephalographic correlates of the clinical response to repetitive transcranial magnetic stimulation: A preliminary comparison between unipolar and bipolar depression.

    abstract：BACKGROUND:Major depressive disorder (MDD) and bipolar disorder (BP) are two different types of mood disorders, sometimes difficult to distinguish from their depressive symptoms, and for which repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex (DLPFC) has been proposed to treat re...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2015.04.029

    authors： Woźniak-Kwaśniewska A,Szekely D,Harquel S,Bougerol T,David O

    更新日期：2015-09-01 00:00:00

  • Association between catechol-O-methyltransferase Val(108/158)Met polymorphism and psychotic features of bipolar disorder.

    abstract：BACKGROUND:Catechol-O-methyltransferase (COMT) inactivates catecholamines, and a G-A transition in the COMT gene (rs4680) influences the enzyme activity and the interaction between cortical and subcortical dopaminergic neurotransmission. Studies in healthy participants and in patients affected by schizophrenia suggeste...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2010.01.005

    authors： Benedetti F,Dallaspezia S,Colombo C,Lorenzi C,Pirovano A,Smeraldi E

    更新日期：2010-09-01 00:00:00

  • The proposed factor structure of temperament and personality in Japan: combining traits from TEMPS-A and MPT.

    abstract：BACKGROUND:In Japan, Kraepelin's descriptions on four "fundamental states" of manic depressive illness, the concepts of schizoid temperament by Kretschmer and obsessional and melancholic type temperament by Shimoda and Tellenbach have been widely accepted. This research investigates the construct validity of these temp...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2004.01.011

    authors： Akiyama T,Tsuda H,Matsumoto S,Miyake Y,Kawamura Y,Noda T,Akiskal KK,Akiskal HS

    更新日期：2005-03-01 00:00:00

  • Parents' behavioral inhibition moderates association of preschoolers' BI with risk for age 9 anxiety disorders.

    abstract：BACKGROUND:Temperamental behavioral inhibition (BI) in children predicts later anxiety disorders. However, many children with BI do not develop anxiety disorders, suggesting the importance of identifying moderating factors. The current study examined whether parents' history of BI moderates the associations between pre...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2016.12.008

    authors： Stumper A,Danzig AP,Dyson MW,Olino TM,Carlson GA,Klein DN

    更新日期：2017-03-01 00:00:00

  • Depression in women with polycystic ovary syndrome: clinical and biochemical correlates.

    abstract：BACKGROUND:We assessed the prevalence of mood disturbance among women with prospectively documented polycystic ovary syndrome (PCOS). METHODS:Thirty-two women with PCOS completed the Center for Epidemiological Studies-Depression Rating Scale (CES-D). Clinical and biochemical characteristics were assessed. RESULTS:Six...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/s0165-0327(02)00117-9

    authors： Rasgon NL,Rao RC,Hwang S,Altshuler LL,Elman S,Zuckerbrow-Miller J,Korenman SG

    更新日期：2003-05-01 00:00:00

  • Association of resting-state network dysfunction with their dynamics of inter-network interactions in depression.

    abstract：BACKGROUND:Network-level brain analysis on resting state has demonstrated that depression is not only associated with intra-network dysfunction, but relates to the disturbed interplay between the networks. However, the underlying associations between the intra-network dysfunction and the disturbed inter-network interac...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2014.12.020

    authors： Wei M,Qin J,Yan R,Bi K,Liu C,Yao Z,Lu Q

    更新日期：2015-03-15 00:00:00

  • A double-blind double-dummy study of citalopram comparing infusion versus oral administration.

    abstract：BACKGROUND:This study compares antidepressant efficacy and tolerability of citalopram given either orally or as a slow drop infusion. METHODS:Citalopram (40 mg/day) was administered double-blindly as tablets or slow-drop infusion during the first 10 days and then open, orally, up to treatment Day 42. RESULTS:In 60 mo...

    journal_title：Journal of affective disorders

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0165-0327(98)00024-x

    authors： Baumann P,Nil R,Bertschy G,Jecker A,Brändli H,Morand J,Kasas A,Vuagniaux O,Ramseier F

    更新日期：1998-06-01 00:00:00

  • Psychological distress in cancer patients in a large Chinese cross-sectional study.

    abstract：BACKGROUND:Although psychological distress is common among patients with chronic diseases, the degree of risk for developing psychological distress is not well-established. Our aim with this study is to determine the odds ratio for psychological distress in patients with cancer as compared to either 1) patients with ch...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2018.11.089

    authors： Rao WW,Yang MJ,Cao BN,You YY,Zhang YY,Liu YY,Kou C,Yu Y,Cassidy RM,Yu Q,Zhang XY

    更新日期：2019-02-15 00:00:00

  • Prefrontal and amygdala engagement during emotional reactivity and regulation in generalized anxiety disorder.

    abstract：BACKGROUND:Emotion dysregulation is prominent in generalized anxiety disorder (GAD), characterized clinically by exaggerated reactivity to negative stimuli and difficulty in down-regulating this response. Although limited research implicates frontolimbic disturbances in GAD, whether neural aberrations occur during emot...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2017.05.013

    authors： Fitzgerald JM,Phan KL,Kennedy AE,Shankman SA,Langenecker SA,Klumpp H

    更新日期：2017-08-15 00:00:00

  • A meta-analysis of depression severity and cognitive function.

    abstract：BACKGROUND:Studies examining the way in which cognitive impairment is associated with depression have produced inconsistent findings. Different severity of depressed mood across studies may account for such conflicting reports. However, inconsistent results have also been reported in relation to the specific associatio...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.jad.2009.04.022

    authors： McDermott LM,Ebmeier KP

    更新日期：2009-12-01 00:00:00

  • Threat to democracy: Physical and mental health impact of democracy movement in Hong Kong.

    abstract：BACKGROUND:This study examined the prevalence and critical predictors of anxiety and depressive symptoms and self-rated health, following the Umbrella Movement in Hong Kong. METHODS:Random digit dialing recruited a population-representative sample of 1208 Chinese Hong Kong citizens (mean age=46.89 years; 63% female) i...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2015.07.005

    authors： Hou WK,Hall BJ,Canetti D,Lau KM,Ng SM,Hobfoll SE

    更新日期：2015-11-01 00:00:00

  • Gender patterns in cost effectiveness of quality improvement for depression: results of a randomized, controlled trial.

    abstract：BACKGROUND:Little is known about gender differences in the costs and outcomes of primary care quality improvement strategies for depression. METHODS:Intent-to-treat analysis of data from a group-level controlled trial, in which matched primary care clinics in the US were randomized to usual care or to one of two inter...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jad.2005.03.018

    authors： Schoenbaum M,Sherbourne C,Wells K

    更新日期：2005-08-01 00:00:00

  • Does guideline-concordant care predict naturalistic outcomes in youth with early stage bipolar I disorder?

    abstract：BACKGROUND:The impact of guideline concordance on naturalistic maintenance treatment outcomes in BD is not known. We sought to evaluate the effect of guideline-concordant care on symptomatic, course and functional outcomes in youth with early-stage BD-I. METHODS:In this file audit study, we examined the prospective co...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2020.09.037

    authors： Sunder P,Chia MF,Filia K,Macneil C,Hasty M,Davey C,McGorry P,Berk M,Cotton S,Ratheesh A

    更新日期：2021-01-01 00:00:00

  • Antenatal depression and anxiety across pregnancy in urban South Africa.

    abstract：BACKGROUND:Depression and anxiety in pregnancy have negative consequences for women and their offspring. High adversity places pregnant women at increased mental health risk, yet there is a dearth of longitudinal research in these settings. Little is known about the pathways by which these problems emerge or persist in...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2020.08.010

    authors： Redinger S,Pearson RM,Houle B,Norris SA,Rochat TJ

    更新日期：2020-12-01 00:00:00

  • Risky cyber behaviors in adolescents with depression: A case control study.

    abstract：OBJECTIVE:This study aimed to compare adolescents diagnosed with major depressive disorder (MDD) and healthy adolescents with regard to cyberbullying, cyber victimization, internet addiction, and digital game addiction. MATERIALS AND METHODS:This cross-sectional study was performed in Selçuk University Hospital. The s...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2020.03.046

    authors： Uçar HN,Çetin FH,Ersoy SA,Güler HA,Kılınç K,Türkoğlu S

    更新日期：2020-06-01 00:00:00

  • Serotonin transporter polymorphisms, microstructural white matter abnormalities and remission of geriatric depression.

    abstract：OBJECTIVE:This study compared microstructural abnormalities in depressed elders and controls and studied the association of the serotonin transporter gene status to white matter abnormalities and to remission of depression. METHODS:The subjects were Caucasians with non-psychotic major depression and normal elders. Dep...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2009.03.004

    authors： Alexopoulos GS,Murphy CF,Gunning-Dixon FM,Glatt CE,Latoussakis V,Kelly RE Jr,Kanellopoulos D,Klimstra S,Lim KO,Young RC,Hoptman MJ

    更新日期：2009-12-01 00:00:00

  • Adaptation and psychometric validation of the Prolonged Grief Disorder scale among widows in central Nepal.

    abstract：BACKGROUND:Symptoms of grief vary by culture and societal reactions to death may be gender specific. We aimed to validate a Nepali language version of the Prolonged Grief-13 item scale (PG-13) among widows. METHODS:We tested two adapted versions of a Prolonged Grief Disorder (PGD) instrument with 204 Nepali-speaking w...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2020.12.018

    authors： Surkan PJ,Garrison-Desany HM,Rimal D,Luitel NP,Kim Y,Prigerson HG,Shrestha S,Tol W,Murray SM

    更新日期：2021-02-15 00:00:00

  • A longitudinal study of Latino and non-Hispanic mothers' and fathers' depressive symptoms and its association with parent-child communication.

    abstract：BACKGROUND:Roughly 8% of the U.S. population report moderate or severe depression for two or more weeks and Latinos (3.7%) report higher rates of severe depression compared to non-Hispanic whites (2.6%) (Pratt and Brody, 2014). As the Latino population continues to grow in the U.S., there is little research on the mani...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章,评审

    doi：10.1016/j.jad.2017.10.046

    authors： De Luca SM,Yueqi Y,DiCorcia D,Padilla Y

    更新日期：2018-02-01 00:00:00

  • Antidepressive effect of left dorsolateral prefrontal cortex neurofeedback in patients with major depressive disorder: A preliminary report.

    abstract：:Background Real-time functional magnetic resonance imaging neurofeedback (rtfMRI-nf) have recently attracted attention as a novel, individualized treatment method for major depressive disorder (MDD). In this study, the antidepressant effect of neurofeedback training for left dorsolateral prefrontal cortex (DLPFC) acti...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2020.03.080

    authors： Takamura M,Okamoto Y,Shibasaki C,Yoshino A,Okada G,Ichikawa N,Yamawaki S

    更新日期：2020-06-15 00:00:00

  • Duration of subsequent episodes and periods of recovery in recurrent major depression.

    abstract：BACKGROUND:Little is known about the duration of subsequent depressive episodes and periods of recovery, and much is based on potentially biased retrospective data. We therefore prospectively assessed whether duration of depressive episodes and recoveries is correlated within subjects and across episodes, and whether d...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.jad.2009.12.013

    authors： de Jonge P,Conradi HJ,Kaptein KI,Bockting CL,Korf J,Ormel J

    更新日期：2010-09-01 00:00:00

  • Imbalanced spontaneous brain activity in orbitofrontal-insular circuits in individuals with cognitive vulnerability to depression.

    abstract：BACKGROUND:The hopelessness theory of depression posits that individuals with negative cognitive styles are at risk of developing depression following negative life events. The purpose of this work was to examine whether individuals with cognitive vulnerability to depression (CVD) exhibit similar spontaneous brain acti...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2016.03.001

    authors： Zhang X,Di X,Lei H,Yang J,Xiao J,Wang X,Yao S,Rao H

    更新日期：2016-07-01 00:00:00

  • GWAS and systems biology analysis of depressive symptoms among smokers from the COPDGene cohort.

    abstract：BACKGROUND:Large sample GWAS is needed to identify genetic factors associated with depression. This study used genome-wide genotypic and phenotypic data from the COPDGene study to identify genetic risk factors for depression. METHODS:Data were from 9716 COPDGene subjects with ≥10 pack-year history. Depression was defi...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2018.09.003

    authors： Heinzman JT,Hoth KF,Cho MH,Sakornsakolpat P,Regan EA,Make BJ,Kinney GL,Wamboldt FS,Holm KE,Bormann N,Robles J,Kim V,Iyer AS,Silverman EK,Crapo JD,Han S,Potash JB,Shinozaki G,COPDGene Investigators.

    更新日期：2019-01-15 00:00:00