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Serotonin transporter polymorphisms, microstructural white matter abnormalities and remission of geriatric depression.

Abstract：

OBJECTIVE:This study compared microstructural abnormalities in depressed elders and controls and studied the association of the serotonin transporter gene status to white matter abnormalities and to remission of depression. METHODS:The subjects were Caucasians with non-psychotic major depression and normal elders. Depressed subjects received escitalopram 10 mg daily for 12 weeks. Remission was defined as a HDRS score of 7 or below for 2 consecutive weeks. Diffusion tensor imaging was performed and voxel-based analysis of fractional anisotropy (FA) was conducted using age and mean diffusivity as covariates. RESULTS:Depressed elders (N=27) had lower FA than controls (N=27) in several frontolimbic areas. Depressed elderly S-allele carriers also had lower FA than L homozygotes in frontolimbic brain areas, including the dorsal and rostral anterior cingulate, posterior cingulate, dorsolateral prefrontal and medial prefrontal regions, thalamus, and in other regions. S-allele carriers had a lower remission rate than L homozygotes. LIMITATIONS:Small number of subjects, lack of random sampling, fixed antidepressant dose, short follow-up. CONCLUSIONS:Lower FA was observed in several frontolimbic and other regions in depressed elders compared to controls. Depressed S-allele carriers had both microstructural white matter abnormalities in frontolimbic networks and a low remission rate. It remains unclear whether the risk for chronicity of geriatric depression in S-allele carriers is mediated by frontolimbic compromise. However, these observations set the stage for studies aiming to identify the relationship of S allele to impairment in specific frontolimbic functions interfering with response of geriatric depression to antidepressants.

journal_name

J Affect Disord

journal_title

Journal of affective disorders

authors

Alexopoulos GS,Murphy CF,Gunning-Dixon FM,Glatt CE,Latoussakis V,Kelly RE Jr,Kanellopoulos D,Klimstra S,Lim KO,Young RC,Hoptman MJ

doi

10.1016/j.jad.2009.03.004

subject

Has Abstract

pub_date

2009-12-01 00:00:00

pages

132-41

issue

1-3

eissn

0165-0327

issn

1573-2517

pii

S0165-0327(09)00104-9

journal_volume

119

pub_type

杂志文章

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Serotonin transporter polymorphisms, microstructural white matter abnormalities and remission of geriatric depression.