Abstract:
BACKGROUND:The DSM-IV diagnosis of acute stress disorder (ASD) describes a posttraumatic reaction that occurs two to twenty-eight days following a trauma and involves symptoms of intrusion, avoidance, hyper-arousal and dissociation. A better understanding of ASD and its pathogenesis could lead to improved post-trauma health care interventions. The aim of this study was to determine prospectively whether a combination of clinical, cognitive and demographic variables were predictive of ASD severity in an acutely traumatized sample. METHODS:We assessed demographic (e.g. age, gender, education), clinical (e.g. sleep quality, trait anxiety, previous psychiatric diagnoses), and cognitive (e.g. negative cognitions following trauma) variables in a sample of 125 adult motor vehicle accident survivors (age: 32.26±9.99; gender: 56.6% male) approximately 10 days after the accident. Univariate analyes and stepwise linear regression were performed to identify variables predictive of ASD severity. RESULTS:Although a number of factors were individually associated with ASD severity, in a regression model only 3 factors, trait anxiety, suicide risk and post-traumatic cognitions, emerged as predictive of the severity of the disorder. LIMITATIONS:The cross-sectional nature of the study and use of self-report measures are important to bear in mind. CONCLUSIONS:Higher levels of trait anxiety, risk for suicide and negative appraisals of the traumatic event were predictive of ASD severity. As these factors may help to identify those who may be at risk of more severe responses after a traumatic event, and who may benefit from secondary prevention strategies, they should be assessed for in acute trauma survivors.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Suliman S,Troeman Z,Stein DJ,Seedat Sdoi
10.1016/j.jad.2013.01.041subject
Has Abstractpub_date
2013-07-01 00:00:00pages
277-81issue
1-3eissn
0165-0327issn
1573-2517pii
S0165-0327(13)00096-7journal_volume
149pub_type
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journal_title:Journal of affective disorders
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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journal_title:Journal of affective disorders
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journal_title:Journal of affective disorders
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journal_title:Journal of affective disorders
pub_type: 临床试验,杂志文章
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journal_title:Journal of affective disorders
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journal_title:Journal of affective disorders
pub_type: 杂志文章
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journal_title:Journal of affective disorders
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journal_title:Journal of affective disorders
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Journal of affective disorders
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doi:10.1016/j.jad.2011.09.002
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journal_title:Journal of affective disorders
pub_type: 杂志文章,评审
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journal_title:Journal of affective disorders
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doi:10.1016/j.jad.2007.03.007
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2020.10.026
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/s0165-0327(98)00075-5
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journal_title:Journal of affective disorders
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pub_type: 杂志文章,评审
doi:10.1016/j.jad.2020.11.039
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journal_title:Journal of affective disorders
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journal_title:Journal of affective disorders
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2015.02.016
更新日期:2015-05-15 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2018.07.025
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journal_title:Journal of affective disorders
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2019.02.048
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:Early intervention in depression has been critical to prevent its negative impact including suicide. Recent blood biomarker studies for major depressive disorder (MDD) have suggested that tryptophan-kynurenine and lipid related metabolites are involved in the pathophysiology of MDD. However, there have been ...
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pub_type: 杂志文章
doi:10.1016/j.jad.2018.01.014
更新日期:2018-04-15 00:00:00