Abstract:
BACKGROUND:The association between loneliness and suicide is poorly understood. We investigated how living alone, loneliness and emotional support were related to suicide and self-harm in a longitudinal design. METHODS:Between 2006 and 2010 UK Biobank recruited and assessed in detail over 0.5 million people in middle age. Data were linked to prospective hospital admission and mortality records. Adjusted Cox regression models were used to investigate relationships between living arrangements, loneliness and emotional support, and both suicide and self-harm as outcomes. RESULTS:For men, both living alone (Hazard Ratio (HR) 2.16, 95%CI 1.51-3.09) and living with non-partners (HR 1.80, 95%CI 1.08-3.00) were associated with death by suicide, independently of loneliness, which had a modest relationship with suicide (HR 1.43, 95%CI 0.1.01-2.03). For women, there was no evidence that living arrangements, loneliness or emotional support were associated with death by suicide. Associations between living alone and self-harm were explained by health for women, and by health, loneliness and emotional support for men. In fully adjusted models, loneliness was associated with hospital admissions for self-harm in both women (HR 1.89, 95%CI 1.57-2.28) and men (HR 1.74, 95%CI 1.40-2.16). LIMITATIONS:Loneliness and emotional support were operationalized using single item measures. CONCLUSIONS:For men - but not for women - living alone or living with a non-partner increased the risk of suicide, a finding not explained by subjective loneliness. Overall, loneliness may be more important as a risk factor for self-harm than for suicide. Loneliness also appears to lessen the protective associations of cohabitation.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Shaw RJ,Cullen B,Graham N,Lyall DM,Mackay D,Okolie C,Pearsall R,Ward J,John A,Smith DJdoi
10.1016/j.jad.2020.10.026subject
Has Abstractpub_date
2021-01-15 00:00:00pages
316-323eissn
0165-0327issn
1573-2517pii
S0165-0327(20)32870-6journal_volume
279pub_type
杂志文章abstract:BACKGROUND:Large sample GWAS is needed to identify genetic factors associated with depression. This study used genome-wide genotypic and phenotypic data from the COPDGene study to identify genetic risk factors for depression. METHODS:Data were from 9716 COPDGene subjects with ≥10 pack-year history. Depression was defi...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2018.09.003
更新日期:2019-01-15 00:00:00
abstract:OBJECTIVES:The burden experienced by caregivers of patients with bipolar disorder has been associated with increased caregiver depression, anxiety and mental health service use. As caregiver burden is also associated with poor patient outcome, these findings may indicate a source of distress not only for caregivers, bu...
journal_title:Journal of affective disorders
pub_type: 杂志文章,评审
doi:10.1016/j.jad.2009.04.020
更新日期:2010-02-01 00:00:00
abstract::We retrospectively investigated the relationship between major depression and silent cerebral infarction (SCI) over a 3-year period in 64 patients older than 50 years of age with unipolar depression. All patients underwent magnetic resonance imaging (MRI) at their first admission for depression and were classified int...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/s0165-0327(97)00148-1
更新日期:1998-01-01 00:00:00
abstract::Erythrocyte/plasma lithium ratios were determined in 41 polar manic depressive outpatients maintained on lithium for a mean of 64 months. Sixteen patients experienced affective episodes requiring additional pharmacologic intervention during periods when their plasma lithium averaged 0.7 meq/l or above for at least 3 p...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/0165-0327(82)90005-2
更新日期:1982-09-01 00:00:00
abstract:OBJECTIVE:Depression after stroke (DAS) is a serious complication of stroke that significantly restricts rehabilitation. Brain imaging technology is an important method for studying the emotional network of DAS. However, few studies have focused on dynamic interactions within the network. The aim of this study was to i...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2019.02.020
更新日期:2019-04-15 00:00:00
abstract:BACKGROUND:The Japanese archipelago stretches over 4000km from north to south and has four large islands: Hokkaido, Honshu, Shikoku, and Kyushu. Previously, using the Temperament Evaluation of Memphis, Pisa, Paris and San Diego-auto questionnaire version (TEMPS-A), we compared the hyperthymic scores of residents in Sap...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2017.07.039
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Recent studies have suggested that eating and sleep problems during early childhood may pose as risk factors for mood and anxiety disorders in later life. We aim to study the associations between early childhood sleep and eating problems, specifically high motor activity during sleep and irregularities in sl...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2006.05.025
更新日期:2006-11-01 00:00:00
abstract:BACKGROUND:Interpretation bias, the tendency to interpret ambiguous situations negatively (or to lack a positive bias), is a cognitive vulnerability associated with psychopathology. However, there is a lack of research characterizing this bias in psychiatric samples, including whether it is also a risk factor for suici...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2016.09.021
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Activation syndrome (AS) is a cluster of symptoms listed by the US Food and Drug Administration as possible suicidality precursors during antidepressant treatment. We aimed to clarify whether AS is associated with bipolar II disorder (BP-II) and its related disorder, i.e., bipolar disorder not otherwise spec...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2013.05.077
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:Impulsivity is a key component of the manic behavior of bipolar disorder and is reported to occur in bipolar patients as a stable characteristic, i.e. a trait. Nevertheless, impulsivity has not been widely studied in depressed bipolar patients. We assessed impulsivity in depressed and euthymic bipolar and un...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2006.09.037
更新日期:2007-06-01 00:00:00
abstract:INTRODUCTION:Fragmented REM sleep may impede overnight resolution of distress and increase depressive symptoms. Furthermore, both fragmented REM and depressive symptoms may share a common genetic factor. We explored the associations between REM sleep fragmentation, depressive symptoms, and a polygenic risk score (PRS) ...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2018.11.077
更新日期:2019-02-15 00:00:00
abstract:BACKGROUND:No research has yet focused on hypomanic states in non-clinical early adult populations. The aim of the present study was therefore to assess hypomania in a large non-clinical sample of young adults. METHODS:A total of 862 participants (639 females and 223 males; mean age: M=24.67; SD=5.91) took part in the...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2010.12.007
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:Evidence suggests a bidirectional association between migraine and depression in individuals and in twins. However, whether a bidirectional association between migraine and depression also occurs among siblings (probands and unaffected nontwin siblings) remains unknown. METHODS:Using the Taiwan National Hea...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2020.10.056
更新日期:2021-01-15 00:00:00
abstract:BACKGROUND:Crying, a complex neurobiological behavior with psychosocial and communication features, has been little studied in relationship to the menstrual cycle. METHODS:In the Mood and Daily Life study (MiDL), a community sample of Canadian women aged 18-43 years, n=76, recorded crying proneness and crying frequenc...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2016.08.044
更新日期:2017-01-15 00:00:00
abstract:BACKGROUND:Neuropsychiatric symptoms (NPS) are being increasingly recognized as common serious problems in Alzheimer's disease (AD). However, published data on the prevalence of NPS in persons with AD are conflicting. This meta-analysis aimed to estimate the prevalence of NPS in persons with AD. METHODS:Studies publis...
journal_title:Journal of affective disorders
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.jad.2015.09.069
更新日期:2016-01-15 00:00:00
abstract:BACKGROUND:Previous pharmaco-epidemiological studies have reported increases in the prescription of psychotropic medications after a disaster, reflecting post-disaster changes in psychiatric conditions and mental health service utilization. We investigated changes in the prescription of psychotropic medications in the ...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2017.05.026
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:Transcranial magnetic stimulation (TMS) of the dorsolateral prefrontal cortex is a brain stimulation technique widely used to treat depression. BDNF serum concentrations have been shown to be decreased in patients with major depressive disorder and can be upregulated by several antidepressive treatment strat...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2007.08.008
更新日期:2008-04-01 00:00:00
abstract:BACKGROUND:The 15-item geriatric depression scale (GDS-15) is a short form of GDS and is used to screen, diagnose, and evaluate depression in elderly individuals. Most previous studies evaluated the ability of GDS-15 to discriminate between depressive and non-depressive states. In this study, we investigated the multi-...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2019.08.053
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:A heightened sensitivity to social rejection might contribute towards the interpersonal difficulties and symptoms that characterise Anorexia Nervosa (AN). This paper examines the effect of Cognitive Bias Modification for Interpretation biases (CBM-I) training on a negative interpretation bias for ambiguous s...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2017.11.089
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Obstructive sleep apnea (OSA) is a health hazard since it is associated with neurocognitive dysfunction and cardio-metabolic diseases. The prevalence of OSA among people with serious mental illness (SMI) is unclear. METHOD:We searched major electronic databases from inception till 06/2015. Articles were inc...
journal_title:Journal of affective disorders
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.jad.2016.02.060
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Clinically derived follow-up studies examining the predictors of suicide attempts (SA) and non-suicidal self-injury (NSSI) among adolescents are scarce. The aims were to study SA and NSSI as predictors of future NSSI and SA, and to study the role of other risk and protective factors, especially alcohol use, ...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2013.09.031
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Impulsivity (I) and anxiety (A) were hypothesized to be crucial clinical features in adolescents with at-risk behavior. We therefore classified them into sub-groups according to these two major dimensions. The study examined the relevance of these groups by describing their major diagnoses and behavioral cha...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/s0165-0327(02)00455-x
更新日期:2003-05-01 00:00:00
abstract::Platelet monoamine oxidase activity (MAO) and clinical symptoms were examined in 116 individuals, 32 acute depressed patients and 84 healthy controls. The enzyme activity was lower in depressed women than controls. MAO activity correlated positively with rated clinical state in depressed women but not in depressed men...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/0165-0327(95)00043-m
更新日期:1995-10-09 00:00:00
abstract:BACKGROUND:Abnormal social behaviour, which is a common feature of psychiatric disorders, is associated with rejection. A passive lack of participation or involvement has been studied as characteristic of depression but active forms of nonparticipation have received little experimental attention. This study examined th...
journal_title:Journal of affective disorders
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0165-0327(02)00036-8
更新日期:2003-06-01 00:00:00
abstract:BACKGROUND:Clinical studies suggest that olfactory sensitivity is reduced in major depression. Nevertheless, only little is known about the relationship between depressive symptoms and olfactory functions in healthy subjects. METHODS:The present study investigated the association between depressive symptoms and olfact...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2006.12.012
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND:Structural and Electroencephalography (EEG) abnormalities in right temporoparietal cortex have been associated with family history of depression (FH). Here we investigate if functional abnormalities in this area, indexed by attenuated responses to emotionally arousing stimuli, are also family-history-depende...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2015.02.031
更新日期:2015-06-01 00:00:00
abstract::Hypofolatemia can cause psychiatric disturbances of a depressive nature. Pregnancy and delivery are often associated with hypofolatemia. This study was conducted to determine if hypofolatemia at day 3 post partum is a risk factor for baby blues or post partum depression. To study this hypothesis, 131 post partum women...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/0165-0327(92)90081-g
更新日期:1992-08-01 00:00:00
abstract:BACKGROUND:Alterations of hypothalamic-pituitary-adrenal (HPA) function are well-established in adults with current depression. HPA alterations may persist into remission and confer increased risk for recurrence. METHODS:A modified version of the Trier Social Stress Test (TSST) was administered at baseline to 32 young...
journal_title:Journal of affective disorders
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jad.2012.05.059
更新日期:2012-12-20 00:00:00
abstract:BACKGROUND:The anterior cingulate cortex (ACC) is a key region for the pathophysiology and treatment of depression. However, it remains unclear whether and how the morphology of the ACC is altered in subjects with mood disorders. METHOD:A post mortem morphometric study of the supragenual ACC (Brodmann area 24b) in sev...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2011.03.042
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:Insomnia may predict onset of mental disorders in adults. However, it is unclear whether the same directional relationship exists during the peak age range for the onset of major mental disorders and/or whether other types of sleep-wake disturbance, such as hypersomnia, show similar associations. METHODS:Lo...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2020.08.083
更新日期:2020-12-01 00:00:00