Abstract:
BACKGROUND:The patterns of antidepressant drug prescribing have rarely been studied in large and geographically defined catchment areas. In the present study, we examined the prevalence and distribution of antidepressant prescribing in Lombardy, a northern Italy region of nine million inhabitants. METHODS:This study used the Regional Administrative Database of Lombardy. This database includes all prescriptions reimbursed by the National Health System in the population living in this region. All antidepressant prescriptions dispensed from the 1st January to the 31st December 2001 were extracted and prevalence data calculated by dividing antidepressant users by the total number of male and female residents in each age group. RESULTS:During the study period, 404,238 individuals were dispensed antidepressants, yielding a prevalence of use of 2.85 (95% confidence interval 2.84, 2.87) per 100 males and 5.92 (95% confidence interval 5.90, 5.94) per 100 females. The prevalence of use progressively rose with age in both sexes, with the highest rates in old and very old individuals. The majority of individuals received a pharmacological treatment with selective-serotonin reuptake inhibitors only, slightly more than 12% received a treatment with tricyclic antidepressants. General practitioners issued the majority of antidepressant prescriptions. CONCLUSIONS:The very high rates of antidepressant drug prescribing detected in late life suggest the need of characterising these individuals in terms of medical and psychiatric characteristics, needs and quality of life. It also suggests the need for pragmatic clinical trials, carried out in the general practice, with the aim of assessing whether antidepressants are effective in these conditions.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Percudani M,Barbui C,Fortino I,Petrovich Ldoi
10.1016/j.jad.2004.07.005subject
Has Abstractpub_date
2004-12-01 00:00:00pages
169-75issue
2-3eissn
0165-0327issn
1573-2517pii
S0165-0327(04)00246-0journal_volume
83pub_type
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journal_title:Journal of affective disorders
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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journal_title:Journal of affective disorders
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doi:10.1016/j.jad.2007.05.005
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更新日期:2011-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.jad.2015.03.010
更新日期:2015-07-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2013.05.006
更新日期:2013-09-25 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章,评审
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journal_title:Journal of affective disorders
pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章
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更新日期:2015-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,meta分析,评审
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更新日期:2014-03-01 00:00:00
abstract::In an attempt to improve the classification of Bipolar II disorders, we have examined a consecutive series of 687 primary major depressives: 5.1% gave a past history of mania (Bipolar I), 13.7% met our operational criteria for hypomania (Bipolar II), and the remaining 81.2% were provisionally categorized as 'unipolar....
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pub_type: 杂志文章
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更新日期:1992-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:1999-10-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2000-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-03-15 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
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更新日期:2009-10-01 00:00:00