Abstract:
:This paper reviews evidence from both human and non-human primate studies concerning the role of early adverse experiences in the onset and course of adult depressive disorders. Despite accumulating evidence that stressful life events can play a major role in precipitating the onset of depressive episodes in humans, the mechanisms by which early experiences mediate and moderate the risk for later affective illnesses are not fully understood. Experimental paradigms in primates have documented the important role of undeveloped (social deprivation) or disrupted attachment systems (social separation). Effects of early social deprivation can be seen in many domains. Behavioral effects include repetitive idiosyncratic behaviors, increased self-directed behaviors, inappropriate expression of aggressive behaviors, non-modulated patterns of consumption, and inappropriate sexual and maternal behaviors. Cognitively, such animals require longer habituation time for any task and demonstrate increased perseverance on tasks following non-reward. Physiological effects include an altered hypothalamic-pituitary-adrenal response to stress, changes in diurnal temperature regulation, and alterations in immune function. Neurochemical effects include abnormalities in noradrenergic, serotonergic, and dopaminergic systems. Even neuroanatomical changes following early social deprivation have been reported. Studies with primates have also confirmed that early maternal and peer separations are major behavioral and neurobiological events with both short- and long-term consequences that parallel human depression. Future utilization of experimental paradigms in non-human primates may assist in better understanding the role of early experiences in predisposing to the development of affective illnesses in humans. This review concludes by presenting a model for understanding a developmentally based vulnerability to adult depressions.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Gilmer WS,McKinney WTdoi
10.1016/s0165-0327(03)00046-6subject
Has Abstractpub_date
2003-07-01 00:00:00pages
97-113issue
2eissn
0165-0327issn
1573-2517pii
S0165032703000466journal_volume
75pub_type
杂志文章,评审abstract:BACKGROUND:Neurotrophins including brain-derived neurotropic factor (BDNF) are implicated in the pathogenesis of major depressive disorder (MDD). Yet, the roles of brain-specific BDNF-related miRNAs miR-132 and miR-124 are unclear. METHODS:We enrolled 45 treatment-free patients with MDD, 32 citalopram-treated patients...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2017.11.090
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:The loss of an expected child is a psychologically difficult and potentially traumatic life event. While most women will become pregnant again within a year following the loss, data are limited regarding the mental health of parents with a history of perinatal loss, especially in the period following the bir...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2020.11.016
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND:Since its introduction in DSM-III, the validity of dysthymia has been debated. Our objective is to further examine the concept of dysthymia in an outpatient sample, and explore whether its constituents can be meaningfully apportioned. METHODS:318 patients attending the Black Dog Institute Depression Clinic ...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2012.05.051
更新日期:2012-12-20 00:00:00
abstract::Data regarding open-label treatment with fluoxetine following failure to respond to tricyclic antidepressants (TCAs) or intolerance of TCA side effects, suggest a response rate between 51.4% and 62.1%, depending on the definition of TCA refractoriness employed. Double-blind study of this issue would extend these findi...
journal_title:Journal of affective disorders
pub_type: 临床试验,杂志文章
doi:10.1016/0165-0327(90)90144-w
更新日期:1990-11-01 00:00:00
abstract:INTRODUCTION:Psychotic symptoms in bipolar II disorder, allowed by definition only during a depressive episode, are present in a range between 3% and 45%. Little is known regarding the impact of psychotic symptoms on the clinical course of bipolar II patients. Findings from previous reports are controversial and focuse...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2010.03.028
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:It has been proposed that a history of suicide attempts could be a correlate of severe depressive disorder and that suicide attempters (SA) could represent a particular subtype of subjects suffering from major depressive disorder. We investigated clinical and demographic characteristics associated with SA an...
journal_title:Journal of affective disorders
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.jad.2009.09.001
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:The aim of this study was to find the sociodemographic and clinical characteristics of major depressive episode (MDE) with (MDE-HPS+) and without a history of psychotic symptoms (MDE-HPS) in the general population. METHODS:The Mental Health in the General Population survey interviewed 38,694 individuals in ...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2020.04.048
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Higher depressive symptoms have been associated with lower future income. However, studies examining this issue have had limited follow-up times and have used self-reported measures of income. Also, possible confounders or mediators have not been accounted. METHODS:971 women and 738 men were selected from t...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2016.06.028
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:Coexisting anxiety is common in major depressive disorder (MDD) and more difficult to treat than depression without anxiety. This analysis assessed the efficacy, safety, and tolerability of vortioxetine in MDD patients with high levels of anxiety (baseline Hamilton Anxiety Rating Scale [HAM-A] total score ≥2...
journal_title:Journal of affective disorders
pub_type: 杂志文章,meta分析
doi:10.1016/j.jad.2016.07.015
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Depressed and anxious patients often combine complementary and alternative medicine (CAM) therapies with conventional pharmacotherapy to self-treat symptoms. The benefits and risks of such combination strategies have not been fully evaluated. This paper evaluates the risk-benefit profile of CAM augmentation ...
journal_title:Journal of affective disorders
pub_type: 杂志文章,评审
doi:10.1016/j.jad.2013.05.042
更新日期:2013-09-25 00:00:00
abstract:BACKGROUND:Antidepressant treatment is associated with a high rate of poor response, and thus, biomarker development is warranted. METHODS:We aimed to synthesize studies investigating gene expression, small RNAs, and epigenomic biomarkers of antidepressant response. We conducted a narrative review of the literature. ...
journal_title:Journal of affective disorders
pub_type: 杂志文章,评审
doi:10.1016/j.jad.2017.08.087
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Identification of potentially modifiable risk factors for recurrence in recurrent depression could provide opportunities to improve preventive interventions. In this study we aimed to examine the predictive value of medically unexplained physical symptoms (MUPS) on time to recurrence in recurrent depression....
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2011.10.024
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:This study aimed to test the validity of using the Hypomania Checklist-16 [HCL-16] to measure hypomania in a British adolescent community sample. Limited research is available concerning the characterization of hypomania among community adolescent samples, particularly in the UK, despite its potential import...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2016.08.033
更新日期:2017-01-01 00:00:00
abstract:INTRODUCTION:The objective was to estimate the rate of subjects who tested positive at a screening for bipolar disorders among the people insured by a French Health Company, and subsequently to measure treatment patterns. METHODS:Cross-sectional postal survey on the "Mutuelle Générale de l'Education Nationale" (MGEN) ...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2013.01.007
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:Bipolar psychopathology is characterized by affective dysregulation independent of mood episodes. However, previous research has relied on laboratory-based emotion-eliciting tasks or retrospective questionnaires that do not take into account temporal dynamics of affect. Thus, the present study examined affec...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2019.01.053
更新日期:2019-05-15 00:00:00
abstract:BACKGROUND:The present study aimed to assess the relationship between maternal depression trajectories from pregnancy to 2 years after childbirth and childhood behavioral problems and executive function at 9 years. METHODS:Data of mother-child pairs (N = 1191) extracted from the Panel Study on Korean Children (a cohor...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2020.07.065
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:Sympathetic nervous function abnormalities have long been suggested to be a possible etiology of panic disorder (PD). Catechol-O-methyltransferase (COMT) affects sympathetic activities, and the COMT Val(158)Met polymorphism has been suggested to be related to PD. The authors examined the relationship between...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2009.10.008
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:Acute administration of subanesthestic doses of intravenous ketamine have been shown to elicit a rapid antidepressant response in patients with treatment-resistant depression. However, it remains to be seen if repeated doses over a longer period of time will have the same effects. Here, we assess the long-te...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2012.10.015
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:The standard evolutionary explanation for depression is that being in an emotionally depressed state is adaptive. METHOD:The article first undertakes a critical review of the extant literature. It then provides an alternative evolutionary explanation for event-based depression and elation. It argues that be...
journal_title:Journal of affective disorders
pub_type: 杂志文章,评审
doi:10.1016/j.jad.2014.06.052
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Depression is the single largest contributor to non-fatal health loss worldwide. A role of inflammation in major depressive disorder (MDD) was suggested, and we sought to determine if cytokine levels predict the severity of depressive symptomatology or distinguish MDD patients from healthy controls (HCs). M...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2019.02.042
更新日期:2019-04-15 00:00:00
abstract::Lithium is clearly more effective than placebo in the treatment of mania but the delay in its action requires that alternative drugs be used in the control of the acute episode. This review examines the comparative effects of lithium and neuroleptics and the combination of lithium with (i) haloperidol, (ii) carbamazep...
journal_title:Journal of affective disorders
pub_type: 临床试验,杂志文章
doi:10.1016/0165-0327(85)90023-0
更新日期:1985-05-01 00:00:00
abstract:BACKGROUND:Quantitative EEG studies have identified a number of sleep abnormalities in adults with major depressive disorders (MDD), including a reduction in the amplitude of delta activity during NREM sleep. To date, these methodologies have not been used in early onset MDD. METHODS:Delta activity during NREM sleep w...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/s0165-0327(00)00194-4
更新日期:2001-03-01 00:00:00
abstract:BACKGROUND:Limited published research has examined the relationships of coping styles and sleep quality with anxiety symptoms in Chinese school adolescents. We aimed to explore the effect of coping styles and sleep quality on anxiety symptoms. Furthermore, we investigated the interactions of coping styles and sleep qua...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2019.07.032
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Marital status is one of the most frequently replicated predictors of suicide. The purpose of this study was to examine the effect of marital status on the risk of suicide by gender, using a large population-based cohort in Japan. METHODS:The Miyagi cohort study was a population-based, prospective cohort st...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2013.05.006
更新日期:2013-09-25 00:00:00
abstract:BACKGROUND:Obsessive-compulsive disorder (OCD) is a chronic anxiety disorder of unknown aetiology. Psychopharmacological studies have suggested a role for the neurotransmitter serotonin however further evidence for serotonin in the aetiology of OCD is conflicted. The authors used positron emission tomography (PET) to e...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2008.06.020
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:Repetitive transcranial magnetic stimulation (rTMS) is an effective adjuvant treatment for depression. Many patients with depression have comorbid anxiety symptoms. However, previous rTMS studies have focused on patients with depression, and often excluded comorbid anxiety. This real-world study aimed to inv...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2020.05.151
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:As many local municipality and medical workers were involved in disaster recovery duties following the Great East Japan Earthquake (GEJE) on March 11, 2011, the aim of this work was to elucidate the distinct trajectories for post-traumatic stress disorder (PTSD) symptoms and associated factors among these pe...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2020.05.152
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVE:To determine prevalence rates and clinical correlates of current DSM-5 eating disorders in patients with bipolar disorder (BP). METHODS:Prevalence rates of current DSM-5- and DSM-IV-defined binge eating disorder (BED), bulimia nervosa (BN), and anorexia nervosa (AN) were assessed with the Eating Disorder Dia...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2015.11.010
更新日期:2016-02-01 00:00:00
abstract::In this clinical, psychometric and polysomnographic study, primary dysthymics (N = 20) were compared with anxious depressives (N = 22), and non-psychiatric controls (N = 11). Beck and MMPI depression scores were similar in the two affective groups. Prominent insomnia occurred in 82% of the anxious group; hypersomnia w...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/s0165-0327(84)80007-5
更新日期:1984-06-01 00:00:00
abstract::Hypofolatemia can cause psychiatric disturbances of a depressive nature. Pregnancy and delivery are often associated with hypofolatemia. This study was conducted to determine if hypofolatemia at day 3 post partum is a risk factor for baby blues or post partum depression. To study this hypothesis, 131 post partum women...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/0165-0327(92)90081-g
更新日期:1992-08-01 00:00:00