Abstract：
BACKGROUND:Antidepressant treatment is associated with a high rate of poor response, and thus, biomarker development is warranted. METHODS:We aimed to synthesize studies investigating gene expression, small RNAs, and epigenomic biomarkers of antidepressant response. We conducted a narrative review of the literature. RESULTS:Firstly, we detailed the challenges involved, in terms of biological tissues, relevant study time frames, and mandatory statistical tools. Secondly we synthesized results obtained in gene expression studies, focusing mainly on genome-wide studies, particularly small non-coding RNA, including micro-RNA and other small RNA species. In addition, we reviewed the potential biomarkers of antidepressant response arising from studies investigating DNA methylation variation and histone modifications. LIMITATIONS:We did not conduct a meta-analysis due to the heterogeneity of the study. CONCLUSION:Although promising, the field of gene expression and epigenomic biomarkers of antidepressant response is still in its infancy, and needs further development to define useful biomarkers in clinical practice.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Belzeaux R,Lin R,Ju C,Chay MA,Fiori LM,Lutz PE,Turecki Gdoi
10.1016/j.jad.2017.08.087subject
Has Abstractpub_date
2018-06-01 00:00:00pages
36-44eissn
0165-0327issn
1573-2517pii
S0165-0327(17)30940-0journal_volume
233pub_type
杂志文章,评审abstract：BACKGROUND:While depression is common in residential aged care settings, there is an absence of research into factors that may be associated with this condition. This pilot study examined the relationship between depression and multiple biopsychosocial factors among residents of aged care facilities. METHODS:Participa...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2012.05.019
更新日期：2012-12-15 00:00:00
abstract：OBJECTIVES:Childhood trauma is a major public health problem which has a long-term consequence, a few studies have examined the relationship between childhood trauma and clinical features of bipolar disorder, most in western culture, with no such studies done in Chinese culture. METHODS:The CTQ-SF was administered to ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2014.06.017
更新日期：2014-10-01 00:00:00
abstract：BACKGROUND:Bright artificial light improves non-seasonal depression. Preliminary observations suggest that sunlight could share this effect. METHODS:Length of hospitalization was recorded for a sample of 415 unipolar and 187 bipolar depressed inpatients, assigned to rooms with eastern (E) or western (W) windows. RESU...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/s0165-0327(00)00149-x
更新日期：2001-02-01 00:00:00
abstract：BACKGROUND:Pre-treatment sleep disturbance has been shown to predict antidepressant treatment outcomes. How changes in sleep disturbance during acute treatment affect longitudinal outcomes, or whether continuation-phase treatment further improves sleep disturbance, is unclear. METHODS:We assessed sleep disturbance rep...
journal_title：Journal of affective disorders
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doi：10.1016/j.jad.2019.10.033
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:Rejection is an adverse experience that may help explain the heightened risk of self-harm and suicide amongst many societal groups. The aim of this systematic review was to determine the relationship between rejection experiences and self-harm and suicidal ideation. METHOD:The databases PsychINFO, CINAHL, M...
journal_title：Journal of affective disorders
pub_type： 杂志文章,评审
doi：10.1016/j.jad.2018.08.082
更新日期：2019-01-01 00:00:00
abstract：INTRODUCTION:The objective was to estimate the rate of subjects who tested positive at a screening for bipolar disorders among the people insured by a French Health Company, and subsequently to measure treatment patterns. METHODS:Cross-sectional postal survey on the "Mutuelle Générale de l'Education Nationale" (MGEN) ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2013.01.007
更新日期：2013-07-01 00:00:00
abstract：BACKGROUND:We tested if duration and intensity of episodes in treatment-resistant affectively ill patients were related to cerebrospinal fluid (CSF) concentrations of monoamine metabolites. METHOD:In retrospective life charts were recorded every previous episode of 37 patients with severe treatment-refractory affectiv...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/s0165-0327(02)00011-3
更新日期：2003-04-01 00:00:00
abstract：BACKGROUND:As many local municipality and medical workers were involved in disaster recovery duties following the Great East Japan Earthquake (GEJE) on March 11, 2011, the aim of this work was to elucidate the distinct trajectories for post-traumatic stress disorder (PTSD) symptoms and associated factors among these pe...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2020.05.152
更新日期：2020-09-01 00:00:00
abstract：BACKGROUND:Depression is the predominant pole of illness disability in bipolar disorder and, compared with acute mania, has less systematic research guiding treatment development. The aim of this review is to present the therapeutic options currently available for managing bipolar depression and to highlight areas of u...
journal_title：Journal of affective disorders
pub_type： 杂志文章,评审
doi：10.1016/S0165-0327(14)70005-9
更新日期：2014-12-01 00:00:00
abstract：BACKGROUND:This study examined whether intranasal oxytocin enhances the stress-buffering effects of social support during experimentally induced pain, taking into account the role of individual differences in attachment security. METHODS:Female participants (N = 193) were randomly assigned to oxytocin (24 IU intranasa...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2020.09.057
更新日期：2021-01-01 00:00:00
abstract：BACKGROUND:Clinical and animal studies have reported conflicting results regarding the effect of ketamine on cognitive function, although increasing evidence supports a rapid and sustained antidepressant effect of a subanesthetic dose of ketamine infusion for patients with treatment-resistant depression (TRD). However,...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2018.07.033
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:Conflicting results in genetic studies of bipolar disorders may be due to the clinical and genetic heterogeneity of the disease. Age at onset of bipolar disorders may be a key indicator for identifying more homogeneous clinical subtypes. We tested whether early onset and late onset bipolar illness represent ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/s0165-0327(99)00111-1
更新日期：2000-06-01 00:00:00
abstract：BACKGROUND:Findings from three decades of epidemiological studies suggest that media diffusion of stories about suicide is related to increases in suicidal behaviours in the population exposed to the media reports. However, we still know little about the psychological processes and personal vulnerabilities that prompt ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2011.04.050
更新日期：2011-11-01 00:00:00
abstract：BACKGROUND:Many physical health problems are associated with elevated suicide risk whilst also providing access to means of overdose. We aimed to investigate whether psychiatric patients with physical co-morbidities who die by suicide were more likely than those without co-morbidities to self-poison with non-psychotrop...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2019.06.027
更新日期：2019-10-01 00:00:00
abstract：BACKGROUND:In order to experimentally asses the role of socio-emotional problems in Eating Disorder (ED) psychopathology, we have measured affective states and ED-related attitudes in response to an acute psychosocial stress and their relationships with interpersonal sensitivity in people with Anorexia Nervosa (AN) and...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2020.05.051
更新日期：2020-09-01 00:00:00
abstract：UNLABELLED:Biased inhibitory processing, frequency and valence of automatic thoughts, and inability to use positive schemas to regulate negative mood are cognitive factors linked to depression. These processes may underlie the established link between adaptive cognitive coping strategies (acceptance and positive refram...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2013.05.014
更新日期：2013-09-25 00:00:00
abstract：BACKGROUND:Several self-report rating scales have been developed to assess suicidal ideation, yet few examine other factors related to increased suicidal risk, and even fewer have been validated in both adolescents and adults. We evaluate the 14-item Concise Health Risk Tracking - Self Report (CHRT-SR), a measure previ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2018.03.007
更新日期：2018-08-01 00:00:00
abstract：BACKGROUND:Pediatric bipolar disorder (BPD) can be misdiagnosed as a depressive, attention, conduct, or anxiety disorder and treatment with antidepressants and stimulants is common. Risk of adverse outcomes related to such treatment remains poorly defined. METHODS:We analyzed clinical records of 82 children (mean age ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2003.12.011
更新日期：2004-10-01 00:00:00
abstract：BACKGROUND:Increased inflammation is reported in Major Depressive Disorder (MDD), which may be more pronounced in suicidal subjects. Vitamin D deficiency may drive this pro-inflammatory state due to vitamin D's anti-inflammatory effects. METHODS:We quantified plasma 25-hydroxyvitamin D (25(OH)D) and inflammatory marke...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2020.01.168
更新日期：2020-04-15 00:00:00
abstract：BACKGROUND:The impact of guideline concordance on naturalistic maintenance treatment outcomes in BD is not known. We sought to evaluate the effect of guideline-concordant care on symptomatic, course and functional outcomes in youth with early-stage BD-I. METHODS:In this file audit study, we examined the prospective co...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2020.09.037
更新日期：2021-01-01 00:00:00
abstract：BACKGROUND:Sudden sensorineural hearing loss (SSNHL) occurs as an unexplained, rapid loss of hearing that can cause significant stress in the affected individual. This study aims to assess the risk of depressive disorders in SSNHL patients. METHODS:From the National Health Insurance Research Database (NHIRD) in Taiwan...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2016.03.020
更新日期：2016-06-01 00:00:00
abstract：:An increasing number of computerised transdiagnostic cognitive behavioural therapy programs (TD-cCBT) have been developed in the past decade, but there are no meta-analyses to explore the efficacy of these programs, nor moderators of the effects. The current meta-analysis focused on studies evaluating TD-cCBT interven...
journal_title：Journal of affective disorders
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.jad.2016.03.018
更新日期：2016-07-15 00:00:00
abstract：INTRODUCTION:Creativity is a complex construct involving affective and cognitive components. Bipolar Disorder (BD) has been associated with creativity and is characterized by a wide range of affective and cognitive symptoms. Although studies of creativity in BD have tended to focus on creativity as a trait variable in ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2011.06.024
更新日期：2011-12-01 00:00:00
abstract：OBJECTIVE:To evaluate the rate of depressive symptomatology and possible underlying factors in adoptive mothers during the transition to motherhood. DESIGN:Cohort survey. SETTING:General Community. PARTICIPANTS:Thirty-nine adoptive mothers of reproductive age registered with international adoption agencies. INTERVE...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2008.09.002
更新日期：2009-05-01 00:00:00
abstract：BACKGROUND:Little is known about the duration of subsequent depressive episodes and periods of recovery, and much is based on potentially biased retrospective data. We therefore prospectively assessed whether duration of depressive episodes and recoveries is correlated within subjects and across episodes, and whether d...
journal_title：Journal of affective disorders
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.jad.2009.12.013
更新日期：2010-09-01 00:00:00
abstract：BACKGROUND:fMRI graph theory reveals resting-state brain networks, but has never been used in pediatric OCD. METHODS:Whole-brain resting-state fMRI was acquired at 3T from 21 children with OCD and 20 age-matched healthy controls. BOLD connectivity was analyzed yielding global and local graph-theory metrics across 100 ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2015.12.071
更新日期：2016-03-15 00:00:00
abstract：INTRODUCTION:Bipolar disorder (BD) is a severe mental disorder affecting 1-4% of the population worldwide. It is characterized by periods of (hypo)manic and depressive episodes. Seasonal patterns (SP) may be observed in admission rates, mood relapses and symptom fluctuations. METHODS:We conducted a systematic review o...
journal_title：Journal of affective disorders
pub_type： 杂志文章,评审
doi：10.1016/j.jad.2014.07.002
更新日期：2014-10-01 00:00:00
abstract：BACKGROUND:Second generations antipsychotics (SGA) are frequently used for maintenance treatment in bipolar disorder. We systematically reviewed the efficacy and long-term effects of treatment with SGA, regardless of treatment strategy (SGA administered either as monotherapy or as adjunctive therapy), in comparison to ...
journal_title：Journal of affective disorders
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.jad.2017.02.012
更新日期：2017-04-15 00:00:00
abstract：BACKGROUND:The severity and treatment of depression/anxiety during pregnancy and postpartum has important implications for maternal and child well-being. Yet, little is known about prenatal SSRI use and early child socioemotional development. This study explores effects of prenatal SSRI exposure, and pre- and postnatal...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2019.08.003
更新日期：2019-11-01 00:00:00
abstract：BACKGROUND:Autism spectrum disorder (ASD), a prevalent developmental condition, is associated with comorbid mood disorders, most importantly depression. Here, we explored the underlying association between brain white matter microstructural integrity, assessed by diffusion tensor imaging (DTI), and depressive symptoms,...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2019.08.010
更新日期：2019-12-01 00:00:00
