Abstract：
BACKGROUND:Depression is the predominant pole of illness disability in bipolar disorder and, compared with acute mania, has less systematic research guiding treatment development. The aim of this review is to present the therapeutic options currently available for managing bipolar depression and to highlight areas of unmet need and future research. METHODS:Literature search of PubMed, PsycINFO, and Cochrane databases and bibliographies from 2000 to August 2013 for treatments that have regulatory approval for bipolar depression or early controlled preliminary data on efficacy. RESULTS:Treatment options for bipolar depression have increased over the last decade, most notably with regulatory approval for olanzapine/fluoxetine combination, quetiapine, and lurasidone. Conventional mood stabilizers lamotrigine and divalproex have meta-analyses suggesting acute antidepressant response. Manual-based psychotherapies also appear to be effective in treating bipolar depression. The therapeutic utility of unimodal antidepressants, as a class, for the treatment of patients with bipolar depression, as a group, remains to be confirmed. There is a substantially unmet need to develop new interventions that are efficacious, effective, and have low side effect burden. LIMITATIONS:Additional compounds are currently being developed that may ultimately be applicable to the treatment of bipolar depression and early open-trial data encourage further studies, but both of these topics are beyond the scope of this review. CONCLUSION:Future registrational trials will need to establish initial efficacy, but increasing interest for personalized or individualized medicine will encourage further studies on individual predictors or biomarkers of response.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Frye MA,Prieto ML,Bobo WV,Kung S,Veldic M,Alarcon RD,Moore KM,Choi DS,Biernacka JM,Tye SJdoi
10.1016/S0165-0327(14)70005-9subject
Has Abstractpub_date
2014-12-01 00:00:00pages
S17-23eissn
0165-0327issn
1573-2517pii
S0165-0327(14)70005-9journal_volume
169 Suppl 1pub_type
杂志文章,评审abstract：BACKGROUND:Our aim was to examine associations between depression and time spent in TV viewing in a representative sample of Brazilian adults. METHODS:Data from the Brazilian National Health Survey (Pesquisa Nacional de Saúde - PNS in Portuguese) (n =60,202; ≥18 years) were used. Time spent TV viewing (h/day) was elic...
journal_title：Journal of affective disorders
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abstract：BACKGROUND:Ketamine is known to rapidly reduce depressive symptoms and suicidal ideation (SI) in patients with major depressive disorder (MDD), but evidence is limited for its acceptability and effectiveness in "real-world" settings. This case series examines serial ketamine infusions in reducing SI and depression scor...
journal_title：Journal of affective disorders
pub_type： 杂志文章,随机对照试验
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journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2003.11.008
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abstract：BACKGROUND:This study investigated the role of posttraumatic growth (PTG) in moderating the associations between parenting efficacy and psychological distress, and between fear of cancer recurrence (FCR) and psychological distress, in mothers who are breast cancer survivors. METHODS:In this cross-sectional study, moth...
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journal_title：Journal of affective disorders
pub_type： 杂志文章
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journal_title：Journal of affective disorders
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abstract：BACKGROUND:While major effort has been put in investigating neural correlates of depression and its treatment in adults, less is known about the effects of psychotherapy in adolescents. Given the concordance of the ventral striatum, amygdala, hippocampus and the subgenual anterior cingulate cortex (sgACC) as correlates...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2015.05.020
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pub_type： 杂志文章,评审
doi：10.1016/j.jad.2014.07.002
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journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2013.02.013
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journal_title：Journal of affective disorders
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.jad.2014.12.016
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abstract：BACKGROUND:Limited studies have been conducted to investigate the mental health status of subgroups of university students. This study hypothesized that there would be differences among student subgroups in the prevalence of depression, anxiety and stress; and association of age, gender, academic performance and mental...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2020.05.041
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abstract：BACKGROUND:Previous studies have indicated that obsessive-compulsive disorder (OCD) might have a reduced placebo response compared to other anxiety-related disorders including generalized anxiety disorder, panic disorder, post-traumatic stress disorder, and social anxiety disorder. No previous analysis has directly com...
journal_title：Journal of affective disorders
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.jad.2017.04.068
更新日期：2017-08-15 00:00:00
abstract：BACKGROUND:Perfectionism is a prevalent disposition of personality involved in the development and maintenance of a wide range of psychological disorders. The Child and Adolescent Perfectionism Scale (CAPS) is the most usually applied test to assess perfectionism in children and adolescents. This study aimed: (a) to co...
journal_title：Journal of affective disorders
pub_type： 杂志文章,meta分析,评审
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更新日期：2019-02-15 00:00:00
abstract：:This study examined the primary-secondary distinction with respect to DSM-IV alcohol use disorders and major depression in a large representative sample of the USA. Primary, secondary and concurrent depressives (i.e. the comorbid groups), respondents classified with major depression only and respondents classified wit...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/0165-0327(96)00002-x
更新日期：1996-06-05 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.jad.2016.09.023
更新日期：2017-01-01 00:00:00
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journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/s0165-0327(01)00304-4
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abstract：BACKGROUND:The Temperament Evaluation of Memphis Pisa Paris and San Diego Auto-questionnaire (TEMPS-A) has been translated and validated into several languages, and used in different subgroups (e.g. clinical, students, company, employees and those with different educational levels). METHODS:Lebanon is the only country...
journal_title：Journal of affective disorders
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doi：10.1016/j.jad.2006.06.029
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abstract：BACKGROUND:There is growing evidence that transcranial direct current stimulation (tDCS) may be an effective treatment for depression. However, no study to date has profiled the antidepressant effects of tDCS using items or factors on depression symptom severity rating scales. This could potentially provide information...
journal_title：Journal of affective disorders
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jad.2013.02.027
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journal_title：Journal of affective disorders
pub_type： 杂志文章,评审
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journal_title：Journal of affective disorders
pub_type： 杂志文章,评审
doi：10.1016/j.jad.2013.03.009
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journal_title：Journal of affective disorders
pub_type： 杂志文章
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更新日期：2018-08-01 00:00:00
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journal_title：Journal of affective disorders
pub_type： 杂志文章
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journal_title：Journal of affective disorders
pub_type： 杂志文章
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更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:Postpartum depression (PPD) reportedly affects between 6.5-19% of all new mothers. Identifying those at greatest risk for PPD has implications for prevention, early detection and intervention. While the relationship between extremes of body mass index (BMI) and depression has been frequently studied, the ass...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2018.07.063
更新日期：2018-11-01 00:00:00
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journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2014.04.018
更新日期：2014-08-01 00:00:00
abstract：BACKGROUND:Calls to implement measurement-based care (MBC) in psychiatry are increasing. A recent Cochrane meta-analysis concluded that there is insufficient evidence that routine application of patient reported outcomes (PROs) improves treatment outcomes for common psychiatric disorders. There is a particular paucity ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2020.01.108
更新日期：2020-04-01 00:00:00
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journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2011.10.002
更新日期：2012-02-01 00:00:00
abstract：BACKGROUND:Brain-derived neurotrophic factor (BDNF) has an essential role in synaptic plasticity and neurogenesis. BDNF mediates amygdala-dependent learning for both aversive and appetitive emotional memories. The expression of BDNF in limbic regions is posited to contribute the development of depression, and amygdala ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2020.01.159
更新日期：2020-04-15 00:00:00
