Abstract：
BACKGROUND:Pediatric bipolar disorder (BPD) can be misdiagnosed as a depressive, attention, conduct, or anxiety disorder and treatment with antidepressants and stimulants is common. Risk of adverse outcomes related to such treatment remains poorly defined. METHODS:We analyzed clinical records of 82 children (mean age 10.6 years) meeting modified DSM-IV diagnostic criteria for BPD to evaluate risk and timing of operationally-defined treatment-emergent mania (TEM) or increased mood-cycling following pharmacological treatment. RESULTS:Of 82 juvenile BPD patients, 57 (69%) had been given a mood-elevating agent at least once; 33/57 (58%) so-exposed met criteria for TEM, with median latency of 14 days; TEM was observed twice as often with antidepressants as stimulants (44% vs. 18%). TEM led to first-recognition of BPD in 14 cases (17%), and some drug-exposed children (4-9%) had prominent suicidal, homicidal or psychotic behavior. In addition to recent exposure to a mood-elevating agent, TEM was associated with early-onset anxiety and female gender. LIMITATIONS:Findings are retrospective in clinically diagnosed and treated outpatients, but involved otherwise unselected cases of juvenile BPD. CONCLUSIONS:TEM was reported in 58% of children with probable juvenile BPD within several weeks of new exposure to a mood-elevating agent.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Faedda GL,Baldessarini RJ,Glovinsky IP,Austin NBdoi
10.1016/j.jad.2003.12.011subject
Has Abstractpub_date
2004-10-01 00:00:00pages
149-58issue
1eissn
0165-0327issn
1573-2517pii
S0165032704000266journal_volume
82pub_type
杂志文章abstract：OBJECTIVE:To assemble expert clinical experience and judgement in the treatment of anxiety and related disorders in a systematic, quantitative manner. METHODS:A panel of internationally recognized Experts in treating anxiety and depression was constituted by multistage peer nomination. 90% completed a questionnaire. T...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/0165-0327(95)00064-x
更新日期：1995-12-18 00:00:00
abstract：OBJECTIVE:Depressive symptoms are associated with inflammation yet the association between inflammation and different levels of depression remains unclear. Therefore, we studied the association of subsyndromal and depressive symptoms with inflammatory markers in a large multi-ethnic cohort. METHODS:C-reactive protein ...
journal_title：Journal of affective disorders
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更新日期：2014-08-01 00:00:00
abstract：BACKGROUND:It is commonly assumed that robust evidence exists for the lack of efficacy of antidepressants at the milder end of the depression severity spectrum. In light of specific limitations of existing reviews, we assess if antidepressants are efficacious and tolerable for sub-threshold or mild major depressive dis...
journal_title：Journal of affective disorders
pub_type： 杂志文章,评审
doi：10.1016/j.jad.2014.04.078
更新日期：2014-09-01 00:00:00
abstract：BACKGROUND:This study examines comorbidity of posttraumatic stress disorder (PTSD) and depression following myocardial infarction (MI). It has two aims: (a) to examine whether this comorbidity is predicted by the objective severity of the MI and the patients' initial appraisal and stress responses; and (b) to determine...
journal_title：Journal of affective disorders
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doi：10.1016/j.jad.2006.03.016
更新日期：2006-08-01 00:00:00
abstract：:Sulpiride, in this open study of acute manic patients, had a clear antimanic action with all eight patients responding to sulpiride treatment without the need for other antipsychotic drugs. Plasma prolactin concentrations were increased and oestrogen-stimulated neurophysin concentrations decreased by sulpiride but wer...
journal_title：Journal of affective disorders
pub_type： 临床试验,杂志文章
doi：10.1016/0165-0327(89)90064-5
更新日期：1989-03-01 00:00:00
abstract：BACKGROUND:The symptoms that contribute to the clinical diagnosis of depression likely emerge from, or are related to, underlying cognitive deficits. To understand this relationship further, we examined the relationship between self-reported somatic and cognitive-affective Beck'sDepression Inventory-II (BDI-II) symptom...
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abstract：BACKGROUND:Associations between physical activity (PA) and subclinical anxiety disorder symptoms and status, and potential mediating effect of social physique anxiety (SPA), remain understudied. We examined associations between PA and analogue Generalized Anxiety Disorder (AGAD), analogue Social Anxiety Disorder (ASAD)...
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abstract：INTRODUCTION:Anxiety and depression are often comorbid conditions, but there is uncertainty as to how this comorbidity develops. Thus, in three studies, we attempted to discern whether anhedonia may be a key linking factor between anxiety and depression. METHODS:Three studies asked participants about their symptoms of...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2017.06.006
更新日期：2017-10-15 00:00:00
abstract：BACKGROUND:Alexithymia relates to difficulty recognizing and describing own feelings. Recent literature shows that specific structures process emotions. Aim of this study was to investigate whether alexithymia is associated with a specific cerebral morphology of candidate structures in healthy adults. METHODS:Fifty-fo...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2008.07.013
更新日期：2009-04-01 00:00:00
abstract：BACKGROUND:The bipolar nature of unipolar depression with depressive mixed states (DMX) needs further validation studies. The seasonality of depressive episodes is indicated to be different between unipolar and bipolar depressions. We therefore explored the seasonal pattern of depressive episodes in unipolar depressive...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2005.09.009
更新日期：2006-01-01 00:00:00
abstract：BACKGROUND:Yoga-based interventions may prove to be an attractive option for the treatment of depression. The aim of this study is to systematically review the research evidence on the effectiveness of yoga for this indication. METHODS:Searches of the major biomedical databases including MEDLINE, EMBASE, ClNAHL, PsycI...
journal_title：Journal of affective disorders
pub_type： 杂志文章,评审
doi：10.1016/j.jad.2005.08.013
更新日期：2005-12-01 00:00:00
abstract：BACKGROUND:Computerised cognitive behavioural therapy provides a unique opportunity to collect and analyse data regarding the idiosyncratic content of people's core beliefs about the self, others and the world. METHODS:'Beating the Blues' users recorded a core belief derived through the downward arrow technique. Core ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2015.06.044
更新日期：2015-11-01 00:00:00
abstract：BACKGROUND:Heart Rate Variability (HRV) parameters have been used to evaluate the autonomic nervous system. We hypothesized that patients with major depressive disorder (MDD) and panic disorder (PD) showed different HRV profiles compared to healthy controls. We also hypothesized that we could predict the responder grou...
journal_title：Journal of affective disorders
pub_type： 临床试验,杂志文章
doi：10.1016/j.jad.2018.12.048
更新日期：2019-03-01 00:00:00
abstract：BACKGROUND:Postpartum depression (PPD) is a common and gravely disabling health concern. Repetitive transcranial magnetic stimulation (rTMS) is an FDA approved treatment for major depression and may be a valuable tool in the treatment of PPD. The treatment effect of rTMS is rapid, generally well tolerated, without syst...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2019.11.069
更新日期：2020-03-01 00:00:00
abstract：OBJECTIVE:Although the offspring of parents with major depressive disorder (MDD) are at increased risk to develop disruptive behavior disorders (DBD) in addition to MDD, it remains unclear whether this heightened risk is due to MDD or to comorbid DBD in the parents. METHOD:In a secondary analysis of longitudinal data ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2008.02.019
更新日期：2008-12-01 00:00:00
abstract：BACKGROUND:Repetitive Transcranial Magnetic Stimulation (rTMS) is an effective intervention for treatment-resistant Major Depressive Disorder (MDD). Early improvement during high-frequency left-sided (HFL) stimulation of the dorsolateral prefrontal cortex (DLPFC) is an important predictor of longer-term outcome, but mo...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2020.09.011
更新日期：2020-12-01 00:00:00
abstract：:Using desmethylimipramine (DMI) defined and Na+ dependent [3H]imipramine binding, we have examined both 5-HT uptake sites and sites unrelated to 5-HT uptake, in frontal cortex, putamen and substantia nigra of suicides with a firm retrospective diagnosis of depression and matched controls. No differences were seen betw...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/s0165-0327(97)00126-2
更新日期：1998-01-01 00:00:00
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journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2015.01.058
更新日期：2015-05-01 00:00:00
abstract：BACKGROUND:Several studies have reported a high degree of association of the common conditions of depression, bowel dysmotility and migraine. Mitochondrial dysfunction and mitochondrial DNA (mtDNA) sequence variants have been linked individually to each of these three conditions, providing a plausible hypothesis for th...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2005.05.009
更新日期：2005-09-01 00:00:00
abstract：BACKGROUND:The aim of the present study was to obtain comprehensive information on steroid metabolism in depressed patients. METHODS:24-h urinary steroids were measured by gas chromatography in patients with unipolar recurrent major depression (URMD) compared to controls, and an index of relative activity of the 11bet...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/S0165-0327(03)00199-X
更新日期：2004-07-01 00:00:00
abstract：:Platelet 3H-imipramine binding and monoamine oxidase (MAO) activity were investigated in elderly outpatients with primary major depression, and in a group with depression secondary to medical illness (organic mood disorder, depressed by DSM-III-R criteria) in a multidisciplinary geriatric clinic. The density of the bi...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/0165-0327(88)90091-2
更新日期：1988-09-01 00:00:00
abstract：BACKGROUND:The detection of antenatal depression in resource-limited settings such as Malawi, Africa, is important and requires an accurate and practical screening tool. It is not known which questionnaire would be most suitable for this purpose. METHOD:A rigorously translated and modified Chichewa version of the Edin...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2013.05.036
更新日期：2013-09-25 00:00:00
abstract：BACKGROUND:Epidemiologic surveys consistently document high rates of untreated depression, yet why this unmet need exists is only partially understood. METHODS:We compared untreated depressed, treated depressed and "healthy" subjects on sociodemographic characteristics, need for treatment, and help-seeking attitudes u...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/s0165-0327(98)00116-5
更新日期：1999-05-01 00:00:00
abstract：BACKGROUND:While depression during pregnancy is one of the strongest risk factors for postnatal depression, it has been comparatively little studied, particularly in sub-Saharan Africa. METHODS:Cohort study nested within 4-weekly surveillance of all women of reproductive age to identify pregnancies and collect data on...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2014.04.009
更新日期：2014-08-01 00:00:00
abstract：:We used three rating scales to study diurnal variation of mood in 37 patients with major depressive disorder (17 drug-free patients and 20 treatment refractory patients on stable regimens of antidepressant medication). The three rating scales included global self-ratings administered twice a day; an itemized, prospect...
journal_title：Journal of affective disorders
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1992-11-01 00:00:00
abstract：BACKGROUND:Suicide is a major global mental health problem among college students. The aim of the current study was to explore the association between the psychological strains of the strain theory of suicide and suicidal behaviors among college students. METHODS:Participants comprised 1912 college students (16-28 yea...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2019.08.042
更新日期：2019-12-01 00:00:00
abstract：BACKGROUND:Complementary and alternative medicine (CAM) therapies are used more than conventional therapies by people with self-defined anxiety and depression. Preliminary evidence supports a hypothesis that low plasma concentration of essential fatty acids is associated with depression. Reported here is the result of ...
journal_title：Journal of affective disorders
pub_type： 杂志文章,评审
doi：10.1016/j.jad.2006.02.023
更新日期：2006-07-01 00:00:00
abstract：BACKGROUND:Substantial literature exists on risk factors for suicidal behaviour. However, their comparative strength, independence and specificity for either suicidal ideation or suicide attempt(s) remain unclear. METHODS:The Helsinki University Psychiatric Consortium (HUPC) Study surveyed 287 psychiatric care patient...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2015.12.033
更新日期：2016-03-15 00:00:00
abstract：BACKGROUND:Bright artificial light improves non-seasonal depression. Preliminary observations suggest that sunlight could share this effect. METHODS:Length of hospitalization was recorded for a sample of 415 unipolar and 187 bipolar depressed inpatients, assigned to rooms with eastern (E) or western (W) windows. RESU...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/s0165-0327(00)00149-x
更新日期：2001-02-01 00:00:00
abstract：BACKGROUND:Interpretation bias, which involves interpreting ambiguous social events negatively and catastrophising even mildly negative social events, has been suggested as a key maintenance factor of Social Anxiety Disorder. Although some individual studies and narrative reviews have demonstrated a role for negative i...
journal_title：Journal of affective disorders
pub_type： 杂志文章,评审
doi：10.1016/j.jad.2020.07.121
更新日期：2020-11-01 00:00:00
