Abstract:
BACKGROUND:The aim of the present study was to obtain comprehensive information on steroid metabolism in depressed patients. METHODS:24-h urinary steroids were measured by gas chromatography in patients with unipolar recurrent major depression (URMD) compared to controls, and an index of relative activity of the 11beta-hydroxysteroid dehydrogenase (11beta-HSD) enzyme was calculated. RESULTS:The levels of etiocholanolone (E) (p < 0.05), beta-cortolone (beta-CL) (p < 0.01) were significantly decreased, while levels of allo-tetrahydrocorticosterone (aTHB) (p < 0.05) and cortisol (F) (p < 0.01) were elevated in depressed women. The levels of dehydroepiandrosterone (DHEA) (p < 0.01), tetrahydrocorticosterone (THB) (p < 0.01), beta-CL (p < 0.01), and aTHB (p < 0.05) were found significantly decreased in depressed men. The index of 11beta-HSD activity (p < 0.01) was significantly decreased in patients in both sexes. LIMITATIONS:The sample is limited to only urine samples of patient with URMD; the correlation between the severity of depression and F and DHEA was not analyzed. CONCLUSION:Our investigations confirmed that URMD associated with altered steroid metabolism, which shows gender differences, pointing to the different stress sensibility of women. These differences may be the cause as well as the consequence of the major depression (MD).
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Poór V,Juricskay S,Gáti A,Osváth P,Tényi Tdoi
10.1016/S0165-0327(03)00199-Xsubject
Has Abstractpub_date
2004-07-01 00:00:00pages
55-9issue
1eissn
0165-0327issn
1573-2517pii
S016503270300199Xjournal_volume
81pub_type
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