Abstract：
BACKGROUND:fMRI graph theory reveals resting-state brain networks, but has never been used in pediatric OCD. METHODS:Whole-brain resting-state fMRI was acquired at 3T from 21 children with OCD and 20 age-matched healthy controls. BOLD connectivity was analyzed yielding global and local graph-theory metrics across 100 child-based functional nodes. We also compared local metrics between groups in frontopolar, supplementary motor, and sensorimotor cortices, regions implicated in recent neuroimaging and/or brain stimulation treatment studies in OCD. RESULTS:As in adults, the global metric small-worldness was significantly (P<0.05) lower in patients than controls, by 13.5% (%mean difference=100%X(OCD mean - control mean)/control mean). This suggests less efficient information transfer in patients. In addition, modularity was lower in OCD (15.1%, P<0.01), suggesting less granular - or differently organized - functional brain parcellation. Higher clustering coefficients (23.9-32.4%, P<0.05) were observed in patients in frontopolar, supplementary motor, sensorimotor, and cortices with lower betweenness centrality (-63.6%, P<0.01) at one frontopolar site. These findings are consistent with more locally intensive connectivity or less interaction with other brain regions at these sites. LIMITATIONS:Relatively large node size; relatively small sample size, comorbidities in some patients. CONCLUSIONS:Pediatric OCD patients demonstrate aberrant global and local resting-state network connectivity topologies compared to healthy children. Local results accord with recent views of OCD as a disorder with sensorimotor component.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Armstrong CC,Moody TD,Feusner JD,McCracken JT,Chang S,Levitt JG,Piacentini JC,O'Neill Jdoi
10.1016/j.jad.2015.12.071subject
Has Abstractpub_date
2016-03-15 00:00:00pages
175-84eissn
0165-0327issn
1573-2517pii
S0165-0327(15)30353-0journal_volume
193pub_type
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