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Sympathetic nervous function and the effect of the catechol-O-methyltransferase Val(158)Met polymorphism in patients with panic disorder.

Abstract：

BACKGROUND:Sympathetic nervous function abnormalities have long been suggested to be a possible etiology of panic disorder (PD). Catechol-O-methyltransferase (COMT) affects sympathetic activities, and the COMT Val(158)Met polymorphism has been suggested to be related to PD. The authors examined the relationship between sympathetic nervous function and the COMT Val(158)Met polymorphism in PD patients. METHODS:Fifty-eight patients [Val/Val (51.7%) and Met allele carriers (48.3%)] and 58 age-matched normal control subjects [Val/Val (56.9%) and Met allele carriers (43.1%)] were compared in terms of finger skin temperature, which is known to be a useful marker of sympathetic nervous function. RESULTS:A significant COMT Val(158)Met polymorphismxdiagnosis interaction was found. Specifically, the met allele was found to be associated with a lower skin temperature in PD patients. CONCLUSION:These results suggest that the COMT Met allele is related to the higher sympathetic nervous function observed in PD.

journal_name

J Affect Disord

journal_title

Journal of affective disorders

authors

Kang EH,Song YJ,Kim KJ,Shim HB,Park JE,Yu BH

doi

10.1016/j.jad.2009.10.008

subject

Has Abstract

pub_date

2010-06-01 00:00:00

pages

337-40

issue

1-3

eissn

0165-0327

issn

1573-2517

pii

S0165-0327(09)00468-6

journal_volume

123

pub_type

杂志文章

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