Abstract：
BACKGROUND:Acute administration of subanesthestic doses of intravenous ketamine have been shown to elicit a rapid antidepressant response in patients with treatment-resistant depression. However, it remains to be seen if repeated doses over a longer period of time will have the same effects. Here, we assess the long-term efficacy of repeated intravenous ketamine infusions in three patients with high treatment-resistant depression via a naturalistic observation study. METHOD:Three patients consented to intravenous ketamine infusions as a therapy for their treatment-resistant depression. Patients were administered ketamine at 0.5mg/kg of ideal body weight over 40 min followed by a saline flush until discharge. Severity of depressive symptoms was rated with the Montgomery-Asberg Depression Rating Scale. RESULTS:All three patients responded to the ketamine infusions, but each went through an individualized course of treatment based on their own response. LIMITATIONS:This was an open-label naturalistic observation without blinding, randomization, or a placebo control. CONCLUSIONS:These cases add to the literature supporting the therapeutic effect of low-dose repeated intravenous ketamine for patients with treatment-resistant depression. Further study is needed to define the risks, benefits, indications, and contraindications of this potential treatment.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Szymkowicz SM,Finnegan N,Dale RMdoi
10.1016/j.jad.2012.10.015subject
Has Abstractpub_date
2013-05-01 00:00:00pages
416-20issue
1-3eissn
0165-0327issn
1573-2517pii
S0165-0327(12)00694-5journal_volume
147pub_type
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