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Fluoxetine in tricyclic refractory major depressive disorder.

Abstract：

:Data regarding open-label treatment with fluoxetine following failure to respond to tricyclic antidepressants (TCAs) or intolerance of TCA side effects, suggest a response rate between 51.4% and 62.1%, depending on the definition of TCA refractoriness employed. Double-blind study of this issue would extend these findings. Fluoxetine is well tolerated in patients unable to tolerate TCAs. Within this population, more than 80% of patients unable to tolerate TCAs found fluoxetine acceptable. Fluoxetine, as an alternative to polypharmaceutical augmentation, may represent a logical choice as the next step in therapy for a patient who has initially been treated with a TCA and has proven refractory or intolerant.

journal_name

J Affect Disord

journal_title

Journal of affective disorders

authors

Beasley CM Jr,Sayler ME,Cunningham GE,Weiss AM,Masica DN

doi

10.1016/0165-0327(90)90144-w

subject

Has Abstract

pub_date

1990-11-01 00:00:00

pages

193-200

issue

3

eissn

0165-0327

issn

1573-2517

pii

0165-0327(90)90144-W

journal_volume

20

pub_type

临床试验,杂志文章

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