Abstract:
BACKGROUND:Brain-derived neurotrophic factor (BDNF) is associated with response to antidepressant drugs in mood and anxiety disorders. Prolactin (PRL) is a pituitary hormone with behavioural effects, acting as a neurotrophic factor within the brain and may be involved in antidepressant response. OBJECTIVES:To investigate the relationship between BDNF and PRL genotypes with antidepressant drug response. METHODS:Prospective inception cohort of 186 Russian treatment-free participants (28 men and 158 women) between 18 and 70 years clinically diagnosed with depressive disorder who initiated antidepressant medication. DNA polymorphisms were genotyped for PRL rs1341239, BDNF rs6265 and rs7124442. Primary outcome was measured by differences in Hamilton Depression Rating Scale (∆HAM-D) scores between baseline/week two, week two/week four, and baseline/week four. Linear regression and independent t-test determined the significance between polymorphisms and ∆HAM-D. RESULTS:Comparisons between genotypes did not reveal any significant differences in scores during the first two weeks of treatment. In the latter two weeks, BDNF rs7124442 homozygous C patients responded significantly worse in comparison to homozygous T patients during this period. Further analysis within women and in post-menopausal women found a similar comparison between alleles. LIMITATIONS:Study lasted four weeks, which may be considered short to associate genuine antidepressant effects. CONCLUSIONS:Patients taking tricylic antidepressants were noted to have a significant improvement in ∆HAM-D compared to patients taking SSRIs. Homozygous C BDNF rs712442 patients were found to respond significantly worse in the last two weeks of treatment.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Ochi T,Vyalova NM,Losenkov IS,Levchuk LA,Osmanova DZ,Mikhalitskaya EV,Loonen AJM,Bosker FJ,Simutkin GG,Bokhan NA,Wilffert B,Ivanova SAdoi
10.1016/j.jad.2019.08.058subject
Has Abstractpub_date
2019-12-01 00:00:00pages
432-439eissn
0165-0327issn
1573-2517pii
S0165-0327(19)30740-2journal_volume
259pub_type
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