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Carbamazepine and valproate for the treatment of bipolar disorder: a review of the literature.

Abstract：

:There are an increasing number of pharmacologic therapies for bipolar disorder. Two of these agents, the anticonvulsants carbamazepine (CBZ) and valproate (VPA), were first developed over 30 years ago for the treatment of epilepsy, and subsequent studies demonstrated that they are also effective in the treatment of acute mania and suggest efficacy as maintenance therapy in bipolar disorder. Because VPA and CBZ have been in use for many years, the psychiatric community is familiar with the adverse event profiles of these agents. A review of the clinical data evaluating VPA and CBZ monotherapy for the treatment of acute mania suggests that VPA and CBZ are similarly effective in acute mania. However, when their respective adverse event profiles are considered, VPA may be more tolerable than CBZ for short-term use, while CBZ may be better suited for long-term therapy. Controlled and direct comparative studies, both short and long term, are needed to further clarify the differences between VPA and CBZ.

journal_name

J Affect Disord

journal_title

Journal of affective disorders

authors

Nasrallah HA,Ketter TA,Kalali AH

doi

10.1016/j.jad.2006.04.030

subject

Has Abstract

pub_date

2006-10-01 00:00:00

pages

69-78

issue

1-3

eissn

0165-0327

issn

1573-2517

pii

S0165-0327(06)00216-3

journal_volume

95

pub_type

杂志文章,评审

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