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Course of longitudinal psychosocial functioning in bipolar youth transitioning to adults.

Abstract：

OBJECTIVES:Few studies have examined domain-specific psychosocial functioning in Bipolar Disorder (BD) youths. This prospective study examines (1) Interpersonal Relationships with Family; (2) Interpersonal Relationships with Friends; (3) School/Work; (4) Recreation; (5) Life Satisfaction, in BD youths. METHOD:A Course and Outcome of Bipolar Youth subsample (n = 367; mean intake age = 12.6 years, SD = 3.3; 46.6% female) was previously grouped into 4 Classes based on their illness trajectories and percentage of time euthymic using Latent Class Growth Analysis: Class 1 Predominantly Euthymic; Class 2 Moderately Euthymic; Class 3 Ill with Improving Course; Class 4 Predominantly Ill. Psychosocial functioning within the domains were examined for greater than 10 years using the Adolescent Longitudinal Interval Follow-Up Evaluation. RESULTS:Class 1 demonstrated better functioning across all domains; Class 4 demonstrated worse functioning across all domains. Class 2 showed worsening relationships and recreation, and improvement in work/schoolwork. Class 3 showed variable domain declines and improvements. Despite symptomatic remission, 13%-20% of Class 1 and 20-47% of Classes 1/3 still had impairments across different domains. Early age of BD onset impacted impairment across most domains, and low SES significantly predicted impairment in family relationships. LIMITATIONS:The study does not have a healthy control group to compare functioning findings. CONCLUSIONS:Participants with more symptomatic mood trajectories had greater impairment across domains. Moreover, even with symptomatic remission, participants still exhibited impairment. Each Class and domain had different trajectories for impairment. Results suggest the importance of examining specific (vs. global) domains for targeted treatment, even when symptomatically remitted.

journal_name

J Affect Disord

journal_title

Journal of affective disorders

authors

Lee EJ,Hower H,Jones RN,Birmaher B,Strober M,Goldstein BI,Merranko J,Keller MB,Goldstein TR,Weinstock LM,Dickstein DP,Hunt JI,Diler RS,Ryan ND,Gill MK,Axelson D,Yen S

doi

10.1016/j.jad.2020.03.016

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

109-117

eissn

0165-0327

issn

1573-2517

pii

S0165-0327(19)33092-7

journal_volume

268

pub_type

杂志文章

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