Medication treatment perceptions, concerns and expectations among depressed individuals with Type I Bipolar Disorder.


BACKGROUND:Subjective experience of illness affects outcomes among populations with bipolar disorder (BD). This cross-sectional study combined qualitative and quantitative approaches to evaluate perceived treatment effects, concerns and expectations among 90 individuals with BD. METHODS:Adults with Type I BD, mean age 36.6 years, 51% women, completed a semi-structured interview that was audio taped, transcribed, coded and analyzed along emergent themes. Quantitative scales measured depressive symptoms (Hamilton Depression Scale/HAM-D), psychopathology (Clinical Global Impression/CGI), and insight and treatment attitudes (Insight and Treatment Attitudes Questionnaire/ITAQ). RESULTS:Individuals had moderate depression and psychopathology with good insight into need for treatment. Drug treatment was perceived as beneficial, by "stabilizing" or "balancing" mood (42%, N=38), decreasing anxiety/depressive symptoms (19%, N=17) and improving sleep (10%, N=9). While 39%, (N=35) of individuals denied medication concerns, nearly 29%, (N=26) feared possible long-term effects, particularly diabetes or liver/kidney damage. Media stories and advertisements contributed to medication fears. Hopes and expectations for treatment ranged from those that were symptom or functional status-based, such as desiring mood stabilization and elimination of specific symptoms (23%, N=21), to more global hopes such as "being normal" (20%, N=18) or "cured" (18%, N=16). LIMITATIONS:Limitations include relatively small sample, lack of a comparator, inclusion of only depressed individuals and those willing to discuss their illness experience. CONCLUSIONS:While individuals with BD appreciate the effects of medications, concerns regarding adverse effects and discrepancy between actual and hoped-for outcomes can be substantial. Subjective experience with medications using qualitative and quantitative methods should be explored in order to optimize treatment collaboration and outcomes.


J Affect Disord


Sajatovic M,Jenkins JH,Cassidy KA,Muzina DJ




Has Abstract


2009-06-01 00:00:00














  • Oxcarbazepine (Trileptal) in the treatment of bipolar disorders: a review of efficacy and tolerability.

    abstract::Oxcarbazepine, although structurally similar to carbamazepine, is metabolised very differently. As a consequence, oxcarbazepine's pharmacokinetic profile is comparatively less complex, and a more predictable, linear relationship between oxcarbazepine and blood levels is apparent. Furthermore, hepatic enzyme induction ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,评审


    authors: Hellewell JS

    更新日期:2002-12-01 00:00:00

  • Sociodemographic, pregnancy, obstetric, and postnatal predictors of postpartum stress, anxiety and depression in new mothers.

    abstract:BACKGROUND:The purpose of this paper was to evaluate relationships between sociodemographic, pregnancy, obstetric, and postnatal variables and postpartum depression, anxiety and stress levels in new mothers. METHOD:One-hundred-thirty-nine women completed the baseline questionnaire and 105 completed the follow-up quest...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Clout D,Brown R

    更新日期:2015-12-01 00:00:00

  • The 3-year course and outcome of patients with major depression and silent cerebral infarction.

    abstract::We retrospectively investigated the relationship between major depression and silent cerebral infarction (SCI) over a 3-year period in 64 patients older than 50 years of age with unipolar depression. All patients underwent magnetic resonance imaging (MRI) at their first admission for depression and were classified int...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Yanai I,Fujikawa T,Horiguchi J,Yamawaki S,Touhouda Y

    更新日期:1998-01-01 00:00:00

  • Mortality in affective disorder.

    abstract::472 bipolar patients were followed up retrospectively over 17 years. The patients that died were compared with the general population and a control group. The former comparison showed greater mortality from suicide, cardiovascular and respiratory causes in the index population and the latter, that the deceased were mo...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Sharma R,Markar HR

    更新日期:1994-06-01 00:00:00

  • Psychiatric disorders and functional impairment among disaster victims after exposure to a natural disaster: a population based study.

    abstract:OBJECTIVE:We aimed to examine psychiatric morbidity and functional impairment after a natural disaster. METHOD:Norwegian tourists who survived the 2004 tsunami in Khao Lak (n = 63), a severely affected area in Thailand, were interviewed in person 2.5 years after the disaster. The examination included the Mini Internat...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Hussain A,Weisaeth L,Heir T

    更新日期:2011-01-01 00:00:00

  • Decreased lymphocyte beta-adrenoreceptor function correlates with less agoraphobia and better outcome in panic disorder.

    abstract::Previous studies have demonstrated reduced function of peripheral beta-adrenoreceptors in panic disorder with agoraphobia (PDA). We recently reported that decreased lymphocyte beta-receptor function was associated with milder agoraphobia and better treatment response in PDA. We now report on lymphocyte beta-receptor f...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Maddock RJ,Gietzen DW,Goodman TA

    更新日期:1993-09-01 00:00:00

  • Iowa Gambling Task performance in euthymic bipolar I disorder: a meta-analysis and empirical study.

    abstract:BACKGROUND:The Iowa Gambling Task (IGT) has been recommended as an index of reward sensitivity, which is elevated in bipolar disorder. We conducted a meta-analysis of IGT performance in euthymic bipolar I disorder compared with control participants. Findings indicated that people with bipolar disorder make more risky c...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,meta分析


    authors: Edge MD,Johnson SL,Ng T,Carver CS

    更新日期:2013-08-15 00:00:00

  • Functional brain network topology in parents who lost their only child in China: Post-traumatic stress disorder and sex effects.

    abstract:BACKGROUND:Post-traumatic stress disorder (PTSD) is associated with disruption of the brain network topology; however, little is known about the topological changes and sex effects in PTSD patients following a unique trauma, the loss of an only child, in China. METHODS:Fifty-one lost-only-child parents with PTSD, 93 l...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Luo Y,Qi R,Zhang L,Qing Z,Weng Y,Wang W,Zhang X,Shan H,Li L,Cao Z,Lu G

    更新日期:2019-10-01 00:00:00

  • Obsessive-compulsive symptoms and their links to depression and anxiety in clinic- and community-based pediatric samples: A network analysis.

    abstract:BACKGROUND:Symptoms of depression and anxiety are common in children with obsessive-compulsive disorder (OCD) and associated with more severe OCD, greater impairment, and worse treatment outcome. Beyond twin studies showing that genetic factors contribute to the high co-occurrence, few studies have examined how OCD, de...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Cervin M,Lázaro L,Martínez-González AE,Piqueras JA,Rodríguez-Jiménez T,Godoy A,Aspvall K,Barcaccia B,Pozza A,Storch EA

    更新日期:2020-06-15 00:00:00

  • Increased sensitivity to sad faces in depressive symptomatology: A longitudinal study.

    abstract:BACKGROUND:Negative bias to sad emotional stimuli has repeatedly been identified as a cognitive feature of major depressive disorder, particularly in facial expression recognition. However, it is unknown how negative bias applies to facial expression recognition in individuals with depressive symptoms. METHODS:A total...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Nakamura A,Takizawa R,Shimoyama H

    更新日期:2018-11-01 00:00:00

  • Combined influence of depression severity and low-grade inflammation on incident hospitalization and mortality risk in Italian adults.

    abstract:BACKGROUND:Depression and low-grade systemic inflammation are associated risk factors for hospitalizations and mortality, although the nature of this relationship is under-investigated. METHODS:We performed multivariable Cox regressions of first hospitalization/mortality for all and specific causes vs depression sever...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Gialluisi A,Costanzo S,Castelnuovo AD,Bonaccio M,Bracone F,Magnacca S,De Curtis A,Cerletti C,Donati MB,de Gaetano G,Iacoviello L,Moli-sani Study Investigators.

    更新日期:2021-01-15 00:00:00

  • The relationship of suicide attempts, borderline personality traits, and major depressive disorder in a veteran outpatient population.

    abstract:BACKGROUND:Suicide attempts have been associated to both Major Depression and Borderline Personality Disorder. This report hypothesized that there would be significant clinical differences between psychiatric outpatients with Major Depression, Major Depression with a history of a suicide attempt (but low Borderline tra...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Reich J

    更新日期:1998-05-01 00:00:00

  • Interrelationships between job demands, low back pain and depression: A four-way decomposition analysis of direct and indirect effects of job demands through mediation and/or interaction.

    abstract:BACKGROUND:Psychosocial work stressors may lead to low back pain (LBP) through depressive symptoms or to depression through LBP. Depressive symptoms or LBP may also modify these associations. METHODS:We examined prospective interrelationships between job demands, LBP and depressive symptoms. We used comparable data fr...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Åhlin JK,Halonen JI,Madsen IEH,Rugulies R,Sørensen JK,Magnusson Hanson LL

    更新日期:2021-01-05 00:00:00

  • Development and external validation of a prediction rule for an unfavorable course of late-life depression: A multicenter cohort study.

    abstract:BACKGROUND:Given the poor prognosis of late-life depression, it is crucial to identify those at risk. Our objective was to construct and validate a prediction rule for an unfavourable course of late-life depression. METHODS:For development and internal validation of the model, we used The Netherlands Study of Depressi...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Maarsingh OR,Heymans MW,Verhaak PF,Penninx BWJH,Comijs HC

    更新日期:2018-08-01 00:00:00

  • Association between mood disorders and BMI/overweight using a family study approach.

    abstract:BACKGROUND:We previously demonstrated the specificity of familial transmission of the atypical subtype of depression, primarily characterized by overeating and oversleeping. However, the specific components of this subtype that are familial have not been established. The aim of this paper is to examine whether the fami...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Glaus J,Cui L,Hommer R,Merikangas KR

    更新日期:2019-04-01 00:00:00

  • Comparison of inflammatory cytokine levels among type I/type II and manic/hypomanic/euthymic/depressive states of bipolar disorder.

    abstract:OBJECTIVE:Inflammatory cytokines have been suggested to be the trait or state markers of bipolar disorder, but with inconsistent results. This may be related to small sample sizes and poor control of some important confounding factors. METHODS:Gender/age-matched outpatients with bipolar disorder and normal controls we...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Bai YM,Su TP,Tsai SJ,Wen-Fei C,Li CT,Pei-Chi T,Mu-Hong C

    更新日期:2014-09-01 00:00:00

  • The in vitro immunosuppressive effects of moclobemide in healthy volunteers.

    abstract:BACKGROUND:Many studies have demonstrated that major depression is related to an activation of the inflammatory response system (IRS) with an increased production of proinflammatory cytokines. It has been shown that tricyclic antidepressants and serotonin reuptake inhibitors suppress the activation of the IRS in depres...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Lin A,Song C,Kenis G,Bosmans E,De Jongh R,Scharpé S,Maes M

    更新日期:2000-04-01 00:00:00

  • Association between catechol-O-methyltransferase Val(108/158)Met polymorphism and psychotic features of bipolar disorder.

    abstract:BACKGROUND:Catechol-O-methyltransferase (COMT) inactivates catecholamines, and a G-A transition in the COMT gene (rs4680) influences the enzyme activity and the interaction between cortical and subcortical dopaminergic neurotransmission. Studies in healthy participants and in patients affected by schizophrenia suggeste...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Benedetti F,Dallaspezia S,Colombo C,Lorenzi C,Pirovano A,Smeraldi E

    更新日期:2010-09-01 00:00:00

  • Associations of Body Weight and Waist Circumference with Psychopathology, Substance Use, and Well-Being in an Adult Transdiagnostic Sample.

    abstract:BACKGROUND:Prior studies have established inconsistent associations between body weight and mental health. However, most work has relied on body mass index (BMI) and examination of a single mental health variable. The present study examined associations of BMI and waist circumference with multiple mental health variabl...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Yusufov M,Kopeski LM,Silverman AL,Björgvinsson T

    更新日期:2021-02-15 00:00:00

  • Urinary steroid metabolites and 11beta-hydroxysteroid dehydrogenase activity in patients with unipolar recurrent major depression.

    abstract:BACKGROUND:The aim of the present study was to obtain comprehensive information on steroid metabolism in depressed patients. METHODS:24-h urinary steroids were measured by gas chromatography in patients with unipolar recurrent major depression (URMD) compared to controls, and an index of relative activity of the 11bet...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Poór V,Juricskay S,Gáti A,Osváth P,Tényi T

    更新日期:2004-07-01 00:00:00

  • Neurokinin (NK)-1 receptor expression in monocytes from bipolar disorder patients: a pilot study.

    abstract:BACKGROUND:Neurokinin 1 receptors (NK-1R) have been involved in several psychiatric disorders including major depression, but less is known for bipolar disorder (BD). METHOD:We compared NK-1R expression and Substance P (SP) ability to induce NF-κB activation in monocytes from BD patients and healthy donors (HD), also ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Amoruso A,Bardelli C,Cattaneo CI,Fresu LG,Manzetti E,Brunelleschi S

    更新日期:2015-06-01 00:00:00

  • Dietary manganese intake is inversely associated with depressive symptoms in midlife women: A cross-sectional study.

    abstract:BACKGROUND:To study the association of manganese intake from diet with depressive symptoms in midlife women. METHODS:Data for this cross-sectional study were retrieved from baseline assessment of the Study of Women's Health Across the Nation (SWAN). Linear regression, logistic regression and restricted cubic spline mo...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Li D,Wu Q,Xu W,Zheng H,Tong Y,Li Y

    更新日期:2020-11-01 00:00:00

  • Transdiagnostic computerised cognitive behavioural therapy for depression and anxiety: A systematic review and meta-analysis.

    abstract::An increasing number of computerised transdiagnostic cognitive behavioural therapy programs (TD-cCBT) have been developed in the past decade, but there are no meta-analyses to explore the efficacy of these programs, nor moderators of the effects. The current meta-analysis focused on studies evaluating TD-cCBT interven...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,meta分析,评审


    authors: Newby JM,Twomey C,Yuan Li SS,Andrews G

    更新日期:2016-07-15 00:00:00

  • Biopsychosocial factors related to depression in aged care residents.

    abstract:BACKGROUND:While depression is common in residential aged care settings, there is an absence of research into factors that may be associated with this condition. This pilot study examined the relationship between depression and multiple biopsychosocial factors among residents of aged care facilities. METHODS:Participa...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Davison TE,McCabe MP,Knight T,Mellor D

    更新日期:2012-12-15 00:00:00

  • Noradrenergic and serotoninergic depression?

    abstract::The aim of this study was to test the hypothesis of noradrenergic and serotoninergic depressive subtypes. For this purpose, the correlation between three variables was investigated: urinary 3-methoxy-4-hydroxyphenylglycol (MHPG), dexamethasone suppression test (DST), and clinical response profiles to clomipramine and ...

    journal_title:Journal of affective disorders

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Yazici O,Aricioğlu F,Gürvit G,Uçok A,Taştaban Y,Canberk O,Ozgüroğlu M,Durat T,Sahin D

    更新日期:1993-02-01 00:00:00

  • Free T4 index and clinical outcome in patients with depression.

    abstract:INTRODUCTION:Many studies of patients with major depression have reported that a significant decrease in serum free T(4) index is associated with specific treatments; what has been unanswered is whether these observations are generalizable. This study evaluated baseline thyroid function and its relationship to rapidity...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Abulseoud O,Sane N,Cozzolino A,Kiriakos L,Mehra V,Gitlin M,Masseling S,Whybrow P,Altshuler LL,Mintz J,Frye MA

    更新日期:2007-06-01 00:00:00

  • Assessing the role of the amygdala in fear of pain: Neural activation under threat of shock.

    abstract:INTRODUCTION:The DSM-5 explicitly states that the neural system model of specific phobia is centered on the amygdala. However, this hypothesis is predominantly supported by human studies on animal phobia, whereas visual cuing of other specific phobias, such as dental fear, do not consistently show amygdala activation. ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Sambuco N,Costa VD,Lang PJ,Bradley MM

    更新日期:2020-11-01 00:00:00

  • Pediatric bipolar disorder in a Spanish sample: results after 2.6years of follow-up.

    abstract:INTRODUCTION:Bipolar disorder (BD) often starts in childhood or adolescence. There is considerable scepticism outside the United States over the validity, stability and prevalence of BD in children and adolescents. Persistence of course lends support to the validity of a diagnosis. OBJECTIVES:To describe the longitudi...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Escamilla I,Wozniak J,Soutullo CA,Gamazo-Garrán P,Figueroa-Quintana A,Biederman J

    更新日期:2011-07-01 00:00:00

  • Prevalence of bipolar disorder in panic disorder patients in the Japanese population.

    abstract:BACKGROUND:We examined the rate of bipolar I (BPD-I) and bipolar II disorders (BPD-II) in panic disorder (PD) patients, and compared clinical and psychological variables between PD patients with and without bipolar disorders (BPD). METHODS:Participants were 649 Japanese patients with PD (215 men and 434 women, 38.49 ±...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Sugaya N,Yoshida E,Yasuda S,Tochigi M,Takei K,Otani T,Otowa T,Minato T,Umekage T,Konishi Y,Sakano Y,Chen J,Nomura S,Okazaki Y,Kaiya H,Sasaki T,Tanii H

    更新日期:2013-05-01 00:00:00

  • A three-year longitudinal study of affective temperaments and risk for psychopathology.

    abstract:BACKGROUND:Affective temperaments are presumed to underlie bipolar psychopathology. The TEMPS-A has been widely used to assess affective temperaments in clinical and non-clinical samples. Cross-sectional research supports the association of affective temperaments and mood psychopathology; however, longitudinal research...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: DeGeorge DP,Walsh MA,Barrantes-Vidal N,Kwapil TR

    更新日期:2014-08-01 00:00:00