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Depression induced by treatment with interferon-alpha in patients affected by hepatitis C virus.

Abstract：

BACKGROUND:Several studies found a high incidence rate of neuro-psychiatric complications during long-term therapy with interferon alpha (IFNalpha), e.g. slowness, severe fatigue, hypersomnia, lethargy, depressed mood, mnemonic troubles, irritability, short temper, emotional lability, social withdrawal, and lack of concentration. The aim of this study was to examine the incidence of depressed mood and major depression in patients who were treated with IFNalpha. METHODS:30 patients, affected by chronic active C-hepatitis, have been evaluated at baseline and 3 months after IFNalpha treatment. The evaluation consisted of psychometric assessments employing the DSM-IV criteria and the Montgomery Asberg Depression Rating Scale (MADRS). RESULTS:At end-point, 40.7% of the patients suffered from a full blown major depression, according to the DSM-IV criteria for major depression. IFNalpha treatment induced a significant increase in the MADRS score from baseline to 3 months later. The MADRS items which were significantly increased at end-point were: expressed and unexpressed sadness; irritability; insomnia; loss of appetite; and asthenia. DISCUSSION:The results show that prolonged IFNalpha treatment may induce depressive symptoms and major depression in a considerable number of subjects.

journal_name

J Affect Disord

journal_title

Journal of affective disorders

authors

Bonaccorso S,Marino V,Biondi M,Grimaldi F,Ippoliti F,Maes M

doi

10.1016/s0165-0327(02)00264-1

subject

Has Abstract

pub_date

2002-12-01 00:00:00

pages

237-41

issue

3

eissn

0165-0327

issn

1573-2517

pii

S0165032702002641

journal_volume

72

pub_type

杂志文章

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