Abstract:
BACKGROUND:An elevation of inflammatory markers such as high-sensitivity C-reactive protein (hs-CRP) can be found in patients with depressive disorders. Inflammatory processes are known to influence atherosclerosis and might also mediate the link between depression and diabetes. The present study aimed at comparing hs-CRP and its relationship with atherogenic platelet markers in patients with type 2 diabetes (TD2) and/or newly diagnosed major depression (MD). METHODS:Hs-CRP concentrations in 24 patients with TD2, 21 patients with MD (diagnosed according to ICD-10 and DSM-IV), 19 patients with TD2 and comorbid MD, and 25 healthy controls were compared using analysis of variance. The relationship of hs-CRP with atherogenic platelet markers (CD40, CD40 ligand, soluble CD40L) were examined for the different samples using Pearson's correlations and regression analyses. RESULTS:Hs-CRP levels were not associated with depression (F(1, 80)=0.56, p=.814). There was a trend for higher hs-CRP in diabetes patients (p=.095), but not after adjustment for BMI. CD40 or sCD40L were not related to hs-CRP. For CD40L, regression analysis revealed a significant interaction between hs-CRP and subgroup: Hs-CRP was positively associated with CD40L only in depressed patients without diabetes (B=.334, p<.05). LIMITATIONS:Causal inferences are limited because of the cross-sectional design and the small sample size. CONCLUSIONS:Our results demonstrate preliminary evidence that hs-CRP might contribute to the risk of cardiovascular disease in depressed patients without somatic diseases via its association with platelet expression of CD40L. Further studies are necessary to confirm these findings.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Zahn D,Petrak F,Uhl I,Juckel G,Neubauer H,Hägele AK,Wiltfang J,Herpertz Sdoi
10.1016/j.jad.2012.07.030subject
Has Abstractpub_date
2013-04-25 00:00:00pages
420-5issue
3eissn
0165-0327issn
1573-2517pii
S0165-0327(12)00561-7journal_volume
146pub_type
杂志文章abstract:BACKGROUND:We aimed to examine differential effects of WMH on progression of depressive symptoms according to APOE ε4 status in the elderly. METHODS:We obtained data from elderly Korean subjects (n=707) aged 60 years or older at baseline from the CREDOS study from November 2005 to July 2014. A linear mixed model strat...
journal_title:Journal of affective disorders
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abstract:BACKGROUND:The contribution that recently identified risk factors for Postnatal Depression (PND) made to an existing prenatal screening tool ('Predictive Index' of PND; Cooper et al., 1996) was assessed in an attempt to improve the performance of this measure. METHOD:The Predictive Index and measures of appraisal and ...
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pub_type: 临床试验,杂志文章
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abstract:BACKGROUND:Effective methods to prevent adolescent depressive symptoms could reduce suffering and burden across the lifespan. However, psychological interventions delivered to adolescents show efficacy only in symptomatic or high-risk youth. Targeting causal risk factors and assessing mechanistic change can help devise...
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更新日期:2015-11-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
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journal_title:Journal of affective disorders
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更新日期:2014-08-01 00:00:00
abstract::Severe depression is characterized by anorexia and weight loss, symptoms that could endanger the patient's nutritional state. In order to investigate the nutritional state of depressed patients we determined the following in 113 healthy controls and depressed inpatients: (1) anthropometric variables such as body weigh...
journal_title:Journal of affective disorders
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更新日期:1991-09-01 00:00:00
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journal_title:Journal of affective disorders
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journal_title:Journal of affective disorders
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更新日期:2017-01-15 00:00:00
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journal_title:Journal of affective disorders
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更新日期:1988-05-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
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更新日期:2015-07-15 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2013.12.012
更新日期:2014-03-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2006.04.011
更新日期:2006-08-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章,评审
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更新日期:2000-12-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2020.07.045
更新日期:2020-12-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/0165-0327(91)90038-t
更新日期:1991-03-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章,评审
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更新日期:1998-11-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章,随机对照试验
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journal_title:Journal of affective disorders
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2011.06.012
更新日期:2012-02-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章
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更新日期:1995-05-17 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2012.10.002
更新日期:2013-07-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2015.09.030
更新日期:2016-01-15 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
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更新日期:2014-10-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2015.06.040
更新日期:2015-10-01 00:00:00