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Neural correlates of the ADHD self-report scale.

Abstract：

BACKGROUND:The ADHD Self Report Scale is a self-report measure that assesses attentional problems. We sought to validate the ASRS by establishing neural correlates using functional magnetic imaging in healthy controls and individuals with bipolar disorder (BD), who commonly exhibit attentional problems. METHODS:ASRS questionnaires and functional MRI data in conjunction with the Multi-source Interference Task (MSIT) were collected from 36 healthy control and 36 BD participants. We investigated task specific changes in the dorsal anterior cingulate cortex (dACC, Brodmann area 32) and their correlations with ASRS subscale scores, inattention and hyperactivity, in both cohorts. RESULTS:As hypothesized, the dACC showed significant increases in BOLD activation between the interference and noninterference conditions. For the ASRS scale as well as its Inattention and Hyperactivity subscales, there was a significant negative correlation with the dACC BOLD for the whole group. CONCLUSIONS:The ASRS is sensitive to attentional difficulties in BD, suggesting that it is a valid tool for assessing attentional difficulties in patients with BD.

journal_name

J Affect Disord

journal_title

Journal of affective disorders

authors

Testo AA,Felicione JM,Ellard KK,Peters AT,Chou T,Gosai A,Hahn E,Shea C,Sylvia L,Nierenberg AA,Dougherty DD,Deckersbach T

doi

10.1016/j.jad.2019.10.009

subject

Has Abstract

pub_date

2020-02-15 00:00:00

pages

141-146

eissn

0165-0327

issn

1573-2517

pii

S0165-0327(19)30406-9

journal_volume

263

pub_type

杂志文章

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