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Platelet serotonin uptake in panic disorder.

Abstract：

:Platelet serotonin uptake was measured in 45 patients (12 males, 33 females) with panic attacks and 21 controls (9 males, 12 females). Higher Vmax values were obtained in the patient group than in the controls (100.2 +/- 11.5 vs. 34.9 +/- 3.8 pmol/10(8) platelets/min; P less than 0.0005) while the affinity constant Km was not significantly different (2.28 +/- 0.3 vs. 1.71 +/- 0.18 microM). A value of Vmax in excess of 60 pmol/10(8) platelets/min was observed in 60% of patients and in only 5% of controls. The results point to a specific abnormality of platelet serotonin uptake in patients with panic attacks.

journal_name

J Affect Disord

journal_title

Journal of affective disorders

authors

Norman TR,Judd FK,Gregory M,James RH,Kimber NM,McIntyre IM,Burrows GD

doi

10.1016/0165-0327(86)90062-5

subject

Has Abstract

pub_date

1986-07-01 00:00:00

pages

69-72

issue

1

eissn

0165-0327

issn

1573-2517

pii

0165-0327(86)90062-5

journal_volume

11

pub_type

杂志文章

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