Abstract:
:The frequency of occurrence of prepubertal mania is contingent on how much adherence to episodic disorder with separate periods of mania and depression is required. While manic symptoms superimposed on other psychiatric disorders is not uncommon, non-comorbid bipolar disorder is rare. A number of developmental, phenomenological and assessment considerations may complicate simple extrapolation of adult criteria onto young children. Nevertheless, it is clear that a significant number of preadolescents found in outpatient and inpatient samples meet at least symptom criteria for bipolar disorder. Such children have significant comorbidity and impairment. It is likely that some may develop classical bipolar disorder, some will continue to have substantial affective and behavioral comorbidity as do some complicated bipolar adults, and some will continue to have affective lability superimposed on their other, primary psychiatric disorders. Further research and follow-up will be necessary to determine who develops which outcome.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Carlson GAdoi
10.1016/s0165-0327(98)00179-7subject
Has Abstractpub_date
1998-11-01 00:00:00pages
177-87issue
2eissn
0165-0327issn
1573-2517pii
S0165-0327(98)00179-7journal_volume
51pub_type
杂志文章,评审abstract::Direction of weight change in depression has recently been reported to be mediated by Body Mass Index (BMI). The present study examined the relation between direction of weight change in unipolar depression, BMI, and clinical variables such as severity of depression, melancholia, chronicity and recurrence in 89 patien...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/0165-0327(94)90151-1
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:Little is known about the early phases of bipolar disorders (BPAD) and most of current knowledge derives from putative "high-risk" studies conducted in populations of bipolar off-spring; such information may therefore be relevant only to a sub-group of at-risk subjects. METHODS:Retrospective assessment of t...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2009.12.021
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:Depressive disorders are among the most pressing public health challenges worldwide. Yet, not enough is known about their long-term outcomes. This study examines the course and predictors of different outcomes of depressive disorders in an eleven-year follow-up of a general population sample. METHODS:In a n...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2015.10.043
更新日期:2016-01-15 00:00:00
abstract::Serum thyroid autoantibodies to thyroglobulin (TG) and thyroid microsomes (M) were measured by ELISA prospectively in 37 manic depressive patients prior to receiving lithium carbonate and during therapy with this drug for a mean of 16.2 months. They were also measured once in 27 normal subjects and several times in fi...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/0165-0327(86)90023-6
更新日期:1986-09-01 00:00:00
abstract::Assortative mating was determined in 170 spouses of patients with major affective illness (bipolar and unipolar). An increase in affective disorders was found in both wives of affected men and husbands of affected women. The data suggest that assortative mating is present in the familial transmission of affective diso...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/0165-0327(81)90041-0
更新日期:1981-06-01 00:00:00
abstract:BACKGROUND:Despite an apparent high interest in predictive genetic testing for common multifactorial disorders, few data describe anticipated health behaviour as a consequence of such testing. METHODS:A large population-based public survey with community dwelling adults (N = 1046) ascertained through random digit dial...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2011.06.023
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND:A growing number of functional magnetic resonance imaging (fMRI) studies have been conducted in major depressive disorder (MDD) to elucidate reward-related brain functions. The aim of this meta-analysis was to examine the common reward network in the MDD brain and to further distinguish the brain activation ...
journal_title:Journal of affective disorders
pub_type: 杂志文章,meta分析
doi:10.1016/j.jad.2013.06.039
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:Since the outbreak of 2019 new coronavirus (COVID-19) pneumonia, healthcare workers (HCW) have suffered psychological stress. The present study is to examine the prevalence of stress, anxiety and depression of HCW in China during the COVID-19 epidemic, and to determine the risk factors predicting psychologic...
journal_title:Journal of affective disorders
pub_type: 杂志文章,多中心研究
doi:10.1016/j.jad.2020.05.081
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Depression treatment by General Practitioners (GPs) and patient outcomes improved significantly after a comprehensive 20-h training program of GPs. This study examines whether the effects on patient outcomes are caused by the improvements in the process of care. METHODS:Seventeen GPs participated in the tra...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/S0165-0327(03)00074-0
更新日期:2004-06-01 00:00:00
abstract:BACKGROUND:The N-methyl-d-aspartate receptor antagonist ketamine has rapid antidepressant effects in major depression. Psychotomimetic symptoms, dissociation and hemodynamic changes are known side effects of ketamine, but it is unclear if these side effects relate to its antidepressant efficacy. METHODS:Data from 108 ...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2014.02.017
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVE:Bipolar disorder (BD) is burdensome for patients and healthcare systems. This study evaluated changes in concomitant medication patterns, healthcare utilization, and costs after the initiation of risperidone long-acting injection (RLAI) treatment among BD patients. METHOD:287 BD patients receiving regular RL...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2017.04.074
更新日期:2017-08-15 00:00:00
abstract:STUDY OBJECTIVE:The aim of this preliminary study is to investigate the regional blood flow in response to ECT (electroconvulsive therapy) and to identify any responsive-pattern to the treatment. METHODS: STUDY DESIGN:Single longitudinal prospective study of cohorts. SUBJECTS:For this preliminary study ten patients,...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/s0165-0327(00)00200-7
更新日期:2001-06-01 00:00:00
abstract:BACKGROUND:Obsessive-compulsive disorder (OCD) is a chronic anxiety disorder of unknown aetiology. Psychopharmacological studies have suggested a role for the neurotransmitter serotonin however further evidence for serotonin in the aetiology of OCD is conflicted. The authors used positron emission tomography (PET) to e...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2008.06.020
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:Depression presents a significant burden to both patients and society. One treatment that has emerged is vagus nerve stimulation (VNS), an FDA-approved physical treatment for depressive disorders. However, the application of this intervention has been limited by the involvement of surgery and potential side ...
journal_title:Journal of affective disorders
pub_type: 临床试验,杂志文章
doi:10.1016/j.jad.2016.02.031
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:The purpose of the current study was to examine the factorial dimensions underlying Beck Depression Inventory-II (BDI-II) in a large ethnically and economically diverse sample of postpartum women and to assess their relative contribution in differentiating clinical diagnoses in a subsample of depressed women...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2013.01.039
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:Many physical health problems are associated with elevated suicide risk whilst also providing access to means of overdose. We aimed to investigate whether psychiatric patients with physical co-morbidities who die by suicide were more likely than those without co-morbidities to self-poison with non-psychotrop...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2019.06.027
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:The maternity blues have been studied world-wide and are generally regarded as a cross-cultural phenomenon. However, low prevalence rates of the blues have been reported recently in studies of Japanese women. The purposes of this study are, firstly, to establish whether the low prevalence noted in Japanese w...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/s0165-0327(02)00039-3
更新日期:2003-07-01 00:00:00
abstract:BACKGROUND:Genetic and physiological studies have implicated the striatum in bipolar disorder (BD). Although Glycogen synthase kinase 3 beta (GSK3β) has been suggested to play a role in the pathophysiology of BD since it is inhibited by lithium, it remains unknown how GSK3β activity might be involved. Therefore we exam...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2018.10.371
更新日期:2019-02-15 00:00:00
abstract:BACKGROUND:The effect of disasters on suicidality is not known. We aimed to retrospectively determine the cumulative incidence of suicidal ideation during the 3 years after the Great East Japan Earthquake among residents in temporary housing without prior suicidal ideation, as compared to the general population. Moreov...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2018.01.021
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:The aim of the research was to assess the consensus of clinicians about the appropriate treatments for depression and anxiety in youth, to discover any major differences between clinicians' beliefs and those of young people and their parents, and to assess whether clinicians' beliefs were consistent with cli...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2008.02.021
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND:INN 00835 is a synthetic pentapeptide with a potential for rapid onset of action as an antidepressant. Its efficacy was investigated in a pilot study in patients diagnosed with major depression. METHODS:Fifty two patients received either active drug - INN 00835 (26 patients) - or placebo (26 patients), subc...
journal_title:Journal of affective disorders
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0165-0327(99)00187-1
更新日期:2000-12-01 00:00:00
abstract:BACKGROUND:Major depression is characterized by a decreased antioxidant status, an induction of the inflammatory and oxidative and nitrosative (IO&NS) pathways and inflammatory-neurodegenerative (I&ND) pathways. This study examines two markers of oxidative stress in depression, i.e. plasma peroxides and serum oxidized ...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2009.12.014
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:Psychosocial assessment of self-harm patients by mental health service staff is an important aspect of their care. Nevertheless, in England around half of those attending a general hospital following a self-harm episode do not receive such an assessment. We have investigated the reasons for this and the char...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2005.08.011
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND:Nutraceuticals are a group of compounds of growing interest for mental health professionals. Given the implication of certain nutrients in the onset of bipolar disorder, it has been hypothesized that nutraceuticals might be effective in improving symptoms of the condition (i.e. mania or depression). Our syst...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2019.04.039
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVE:To explore the association between major depressive episodes (MDE) and subsequent mortality in a representative sample of the general household population, with adjustment for other determinants of mortality. METHOD:The analysis used four datasets from the Canadian Community Health Survey (CCHS); the CCHS 1....
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2018.08.030
更新日期:2019-01-01 00:00:00
abstract:INTRODUCTION:Subsyndromal depression has been associated with an increased risk of the development of major depressive disorder (MDD). Since treatment trials of adolescent MDD often result in subsyndromal depression as the outcome, the long-term course of these youth would be useful to understand. METHODS:107 adolesce...
journal_title:Journal of affective disorders
pub_type: 临床试验,杂志文章
doi:10.1016/s0165-0327(00)00189-0
更新日期:2001-03-01 00:00:00
abstract:BACKGROUND:Dissociative symptoms are often seen in patients with mood disorders, but there is little information on possible association with subgroups and temperamental features of these disorders. METHODS:The Dissociative Experience Scale was administered to 85 patients with a DSM-IV Major Depressive Disorder (MDD) ...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2007.10.018
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND:Previous studies reporting cortisol hyposecretion in chronic fatigue syndrome may have been confounded by venepuncture, fasting and hospitalisation. METHODS:Morning and evening salivary cortisol were obtained on consecutive days in the first 3 days of the menstrual cycle and compared in three samples of wom...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/s0165-0327(97)00134-1
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:The aim of this study was to analyze the impact of pretreatment characteristics and personality disorders on the onset of response in the treatment of panic disorder. METHODS:The data of 73 out-patients with panic disorder who had completed at least 6 weeks of a randomized trial of 24 weeks of either paroxe...
journal_title:Journal of affective disorders
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/S0165-0327(03)00043-0
更新日期:2004-05-01 00:00:00
abstract::In an attempt to improve the classification of Bipolar II disorders, we have examined a consecutive series of 687 primary major depressives: 5.1% gave a past history of mania (Bipolar I), 13.7% met our operational criteria for hypomania (Bipolar II), and the remaining 81.2% were provisionally categorized as 'unipolar....
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/0165-0327(92)90044-7
更新日期:1992-10-01 00:00:00